Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1K1 Gene

Aliases for OR1K1 Gene

  • Olfactory Receptor Family 1 Subfamily K Member 1 2 3 5
  • Olfactory Receptor 1K1 3 4
  • Hg99 2 3
  • Olfactory Receptor, Family 1, Subfamily K, Member 1 2
  • OR1K1 5
  • MNAB 2

External Ids for OR1K1 Gene

Previous GeneCards Identifiers for OR1K1 Gene

  • GC09P116667
  • GC09M117253
  • GC09M119065
  • GC09M120987
  • GC09P122642
  • GC09P124602
  • GC09P125563

Summaries for OR1K1 Gene

Entrez Gene Summary for OR1K1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1K1 Gene

OR1K1 (Olfactory Receptor Family 1 Subfamily K Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot Summary for OR1K1 Gene

Gene Wiki entry for OR1K1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1K1 Gene

Genomics for OR1K1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1K1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J122819 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.3 +20.8 20778 5.4 NCOR1 NFIC BHLHE40 MNT TAF9B ELF1 FOXA2 TAL1 STAT5A ZNF318 OR1K1 OR5C1 SNORD90 lnc-RC3H2-2 HSALNG0074257 PDCL lnc-OR1K1-1
GH09J122374 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas 9.3 -423.5 -423517 4.2 IKZF1 ZNF600 NCOR1 ZNF592 CEBPA NFIC CEBPB MBD2 TBP ZNF341 ZBTB26 RC3H2 OR1K1 PTGS1 DAB2IP OR1L3 ENSG00000269970 lnc-OR1J1-2 OR1J2
GH09J122443 Enhancer 1.1 Ensembl ENCODE 10.9 -354.7 -354739 4.5 MYC NCOR1 IKZF1 NFIC NONO HES1 BHLHE40 ARNT TAF9B NBN RC3H2 ZBTB26 PTGS1 MRRF OR1K1 ZBTB6 OR5C1 TTLL11 OR1J2 piR-30350-066
GH09J122453 Enhancer 0.9 Ensembl ENCODE 10.9 -346.4 -346445 1.4 ZNF654 CEBPA REST CEBPB DEK TRIM22 CTCF MAX ZNF217 RAD21 HSALNG0074242 OR1K1 MRRF RBM18 PTGS1 OR5C1 TTLL11 OR1J2 OR1J1 ENSG00000234156
GH09J122580 Enhancer 1 Ensembl ENCODE 9.6 -219.6 -219622 1 NCOR1 JUND ZNF592 NFIC EP300 TAF9B TAL1 ELF1 ZNF316 NFE2 OR1N2 OR1B1 OR1N1 OR1J4 OR1J2 OR1K1 OR1H1P OR1J1 HSALNG0074246 OR1L8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1K1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1K1

Top Transcription factor binding sites by QIAGEN in the OR1K1 gene promoter:
  • AML1a
  • AREB6
  • E47
  • Egr-4
  • ITF-2
  • SEF-1 (1)
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Tal-1beta

Genomic Locations for OR1K1 Gene

Latest Assembly
chr9:122,800,123-122,801,073
(GRCh38/hg38)
Size:
951 bases
Orientation:
Plus strand

Previous Assembly
chr9:125,562,402-125,563,352
(GRCh37/hg19 by Entrez Gene)
Size:
951 bases
Orientation:
Plus strand

chr9:125,562,370-125,563,395
(GRCh37/hg19 by Ensembl)
Size:
1,026 bases
Orientation:
Plus strand

Genomic View for OR1K1 Gene

Genes around OR1K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1K1 Gene

Proteins for OR1K1 Gene

  • Protein details for OR1K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGR3-OR1K1_HUMAN
    Recommended name:
    Olfactory receptor 1K1
    Protein Accession:
    Q8NGR3
    Secondary Accessions:
    • B9EH41
    • Q4VXB7
    • Q96R23

    Protein attributes for OR1K1 Gene

    Size:
    316 amino acids
    Molecular mass:
    34268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1K1 Gene

Post-translational modifications for OR1K1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1K1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1K1 Gene

Domains & Families for OR1K1 Gene

Gene Families for OR1K1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1K1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1K1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 1K1 (OR1K1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGR3

UniProtKB/Swiss-Prot:

OR1K1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1K1: view

Function for OR1K1 Gene

Molecular function for OR1K1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR1K1 Gene

Gene Ontology (GO) - Molecular Function for OR1K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR1K1: view
genes like me logo Genes that share phenotypes with OR1K1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1K1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1K1 Gene

Localization for OR1K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1K1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1K1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with OR1K1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1K1 Gene

Pathways & Interactions for OR1K1 Gene

genes like me logo Genes that share pathways with OR1K1: view

Pathways by source for OR1K1 Gene

Interacting Proteins for OR1K1 Gene

Gene Ontology (GO) - Biological Process for OR1K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA 21873635
genes like me logo Genes that share ontologies with OR1K1: view

No data available for SIGNOR curated interactions for OR1K1 Gene

Drugs & Compounds for OR1K1 Gene

No Compound Related Data Available

Transcripts for OR1K1 Gene

mRNA/cDNA for OR1K1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1K1

Alternative Splicing Database (ASD) splice patterns (SP) for OR1K1 Gene

No ASD Table

Relevant External Links for OR1K1 Gene

GeneLoc Exon Structure for
OR1K1

Expression for OR1K1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1K1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1K1 Gene

This gene is overexpressed in Testis (x7.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1K1

SOURCE GeneReport for Unigene cluster for OR1K1 Gene:

Hs.632681
genes like me logo Genes that share expression patterns with OR1K1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1K1 Gene

Orthologs for OR1K1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1K1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia OR1K1 29 30
  • 89.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OR1K1 29 30
  • 88.5 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR1K1 30
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OR1K1 30
  • 51 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Olfr398 30
  • 46 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 55 (a)
ManyToMany
-- 30
  • 49 (a)
ManyToMany
-- 30
  • 48 (a)
ManyToMany
-- 30
  • 47 (a)
ManyToMany
Species where no ortholog for OR1K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1K1 Gene

ENSEMBL:
Gene Tree for OR1K1 (if available)
TreeFam:
Gene Tree for OR1K1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1K1: view image
Alliance of Genome Resources:
Additional Orthologs for OR1K1

Paralogs for OR1K1 Gene

(450) SIMAP similar genes for OR1K1 Gene using alignment to 1 proteins:

  • OR1K1_HUMAN
genes like me logo Genes that share paralogs with OR1K1: view

Variants for OR1K1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1K1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs7046603 -- p.Trp271Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR1K1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR1K1 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1K1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1K1
Leiden Open Variation Database (LOVD)
OR1K1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR1K1 Gene

Disorders for OR1K1 Gene

Additional Disease Information for OR1K1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR1K1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1K1 Gene

Publications for OR1K1 Gene

  1. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A … Vieira AR (American journal of medical genetics. Part A 2010) 3 40
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4

Products for OR1K1 Gene

Sources for OR1K1 Gene