Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1I1 Gene

Aliases for OR1I1 Gene

  • Olfactory Receptor Family 1 Subfamily I Member 1 2 3 5
  • OR19-20 2 3 4
  • Olfactory Receptor 19-20 3 4
  • Olfactory Receptor 1I1 3 4
  • OR1I1P 2 3
  • OR1I1Q 2 3
  • Olfactory Receptor, Family 1, Subfamily I, Member 1 2
  • OR1I1 5

External Ids for OR1I1 Gene

Previous GeneCards Identifiers for OR1I1 Gene

  • GC19U990225
  • GC19P015059
  • GC19P015060
  • GC19P015197

Summaries for OR1I1 Gene

Entrez Gene Summary for OR1I1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1I1 Gene

OR1I1 (Olfactory Receptor Family 1 Subfamily I Member 1) is a Protein Coding gene. Diseases associated with OR1I1 include Retinal Arteries, Tortuosity Of and Fetal Akinesia Deformation Sequence 1. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1G1.

UniProtKB/Swiss-Prot Summary for OR1I1 Gene

Gene Wiki entry for OR1I1 Gene

Additional gene information for OR1I1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1I1 Gene

Genomics for OR1I1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1I1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015123 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.2 +43.0 43041 3.7 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 LEF1 KDM1A ILVBL ENSG00000268564 lnc-NOTCH3-1 AKAP8 BRD4 ZNF333 TPM4 AKAP8L DDX39A OR1I1
GH19J014678 Enhancer 0.5 FANTOM5 Ensembl 9.4 -403.2 -403211 0.4 STAT1 OR7A17 OR1I1 SLC1A6 LOC107985308 ADGRE3 ZNF333 CLEC17A
GH19J015499 Enhancer 0.8 FANTOM5 ENCODE 1.3 +417.0 417027 0.3 CREB1 PRDM10 ZIC2 PKNOX1 SP1 SP2 ZFHX2 GLIS1 SP3 REST PGLYRP2 CYP4F22 CYP4F2 CYP4F3 CYP4F11 OR10H4 OR1I1 RF00017-2862 lnc-OR7C2-1
GH19J014597 Enhancer 0.4 FANTOM5 dbSUPER 2.2 -484.4 -484412 0.3 ADGRE3 NOTCH3 OR7A17 OR1I1 PRKACA PKN1 ZNF333 RF00017-2849 RF00017-2850 CLEC17A
GH19J015072 Enhancer 1 Ensembl ENCODE 0.4 -8.6 -8621 3.2 CREB1 CTCF RCOR2 TARDBP ZHX2 FOXA1 ZNF512B SMARCA5 CTBP1 CEBPB CASP14 AKAP8 SLC1A6 OR1I1 piR-60146-062 lnc-OR7C2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1I1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1I1

Top Transcription factor binding sites by QIAGEN in the OR1I1 gene promoter:
  • ER-alpha
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1

Genomic Locations for OR1I1 Gene

Genomic Locations for OR1I1 Gene
chr19:15,082,211-15,092,970
(GRCh38/hg38)
Size:
10,760 bases
Orientation:
Plus strand
chr19:15,197,791-15,199,032
(GRCh37/hg19)
Size:
1,242 bases
Orientation:
Plus strand

Genomic View for OR1I1 Gene

Genes around OR1I1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1I1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1I1 Gene

Proteins for OR1I1 Gene

  • Protein details for OR1I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60431-OR1I1_HUMAN
    Recommended name:
    Olfactory receptor 1I1
    Protein Accession:
    O60431
    Secondary Accessions:
    • B2RU23
    • Q96R92

    Protein attributes for OR1I1 Gene

    Size:
    355 amino acids
    Molecular mass:
    39297 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1I1 Gene

Post-translational modifications for OR1I1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR1I1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1I1 Gene

Domains & Families for OR1I1 Gene

Gene Families for OR1I1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1I1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR1I1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 1, subfamily I, member 1 (B2RU23_HUMAN)
  • Olfactory receptor 19-20 (OR1I1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60431

UniProtKB/Swiss-Prot:

OR1I1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1I1: view

Function for OR1I1 Gene

Molecular function for OR1I1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR1I1: view

Phenotypes for OR1I1 Gene

genes like me logo Genes that share phenotypes with OR1I1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1I1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1I1 Gene

Localization for OR1I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1I1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1I1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1I1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1I1 Gene

Pathways & Interactions for OR1I1 Gene

genes like me logo Genes that share pathways with OR1I1: view

Pathways by source for OR1I1 Gene

1 KEGG pathway for OR1I1 Gene

Interacting Proteins for OR1I1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000209540 O60431-OR1I1_HUMAN for OR1I1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1I1: view

No data available for SIGNOR curated interactions for OR1I1 Gene

Drugs & Compounds for OR1I1 Gene

No Compound Related Data Available

Transcripts for OR1I1 Gene

mRNA/cDNA for OR1I1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1I1

Alternative Splicing Database (ASD) splice patterns (SP) for OR1I1 Gene

No ASD Table

Relevant External Links for OR1I1 Gene

GeneLoc Exon Structure for
OR1I1

Expression for OR1I1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1I1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1I1

SOURCE GeneReport for Unigene cluster for OR1I1 Gene:

Hs.631610
genes like me logo Genes that share expression patterns with OR1I1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1I1 Gene

Orthologs for OR1I1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1I1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia OR1I1 30
  • 83.6 (n)
Mouse
(Mus musculus)
Mammalia Or1i2 46 Olfr1357 30 17 31
  • 80.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1087 30
  • 80.35 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 77 (a)
OneToMany
-- 31
  • 73 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia OR1I1 31
  • 65 (a)
OneToOne
Species where no ortholog for OR1I1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1I1 Gene

ENSEMBL:
Gene Tree for OR1I1 (if available)
TreeFam:
Gene Tree for OR1I1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1I1: view image

Paralogs for OR1I1 Gene

(444) SIMAP similar genes for OR1I1 Gene using alignment to 2 proteins:

  • OR1I1_HUMAN
  • B2RU23_HUMAN
genes like me logo Genes that share paralogs with OR1I1: view

Variants for OR1I1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1I1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
777448 Benign: not provided 15,087,724(+) G/A MISSENSE_VARIANT
rs16980312 - p.Ile292Thr
rs59166286 - p.Ile50Phe
rs75323205 - p.Ile282Phe
rs76524797 - p.Met163Leu

Additional dbSNP identifiers (rs#s) for OR1I1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR1I1 Gene

Variant ID Type Subtype PubMed ID
dgv654e214 CNV gain 21293372
esv2758746 CNV gain 17122850
esv3643764 CNV gain 21293372
nsv525115 CNV loss 19592680

Variation tolerance for OR1I1 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.58; 99.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1I1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1I1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1I1 Gene

Disorders for OR1I1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR1I1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search OR1I1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with OR1I1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR1I1 Gene

Publications for OR1I1 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR1I1 Gene

Sources for OR1I1 Gene