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Aliases for OR1G1 Gene

Aliases for OR1G1 Gene

  • Olfactory Receptor Family 1 Subfamily G Member 1 2 3 5
  • Olfactory Receptor 17-209 3 4
  • Olfactory Receptor OR17-8 3 4
  • Olfactory Receptor 1G2 3 4
  • OR17-209 3 4
  • OR1G2 3 4
  • Olfactory Receptor, Family 1, Subfamily G, Member 2 3
  • Olfactory Receptor, Family 1, Subfamily G, Member 1 2
  • Olfactory Receptor 1G1 3
  • OR17-130 3

External Ids for OR1G1 Gene

Previous HGNC Symbols for OR1G1 Gene

  • OR1G2

Previous GeneCards Identifiers for OR1G1 Gene

  • GC17M003344
  • GC17M003371
  • GC17M002980
  • GC17M003236
  • GC17M002976
  • GC17M003029

Summaries for OR1G1 Gene

Entrez Gene Summary for OR1G1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1G1 Gene

OR1G1 (Olfactory Receptor Family 1 Subfamily G Member 1) is a Protein Coding gene. Among its related pathways are GPCRs, Other and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot for OR1G1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1G1 Gene

Additional gene information for OR1G1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1G1 Gene

Genomics for OR1G1 Gene

GeneHancer (GH) Regulatory Elements for OR1G1 Gene

Promoters and enhancers for OR1G1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J002958 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.3 +167.8 167809 3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B ZNF48 GLIS2 DPH1 RAP1GAP2 ENSG00000263345 OR3A2 OR1G1 LOC101927911 GC17P002937
GH17J003550 Enhancer 0.4 FANTOM5 6.7 -422.0 -422014 0.3 ZNF366 ZBTB17 TRPV3 OR1G1 OR1A1 OR1A2 OR1E2 GC17M003518
GH17J003130 Enhancer 0.2 FANTOM5 9.9 -2.6 -2576 0.2 OR3A2 OR1A1 OR1E2 OR1G1 OR1A2 TRPV3 TRPV1 GC17P003146
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1G1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR1G1 gene promoter:
  • AML1a
  • ER-alpha

Genomic Locations for OR1G1 Gene

Genomic Locations for OR1G1 Gene
1,749 bases
Minus strand
998 bases
Minus strand

Genomic View for OR1G1 Gene

Genes around OR1G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1G1 Gene

Proteins for OR1G1 Gene

  • Protein details for OR1G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1G1
    Protein Accession:
    Secondary Accessions:
    • Q4VBM1
    • Q6IFL9
    • Q9UM76

    Protein attributes for OR1G1 Gene

    313 amino acids
    Molecular mass:
    34924 Da
    Quaternary structure:
    No Data Available
    • Sequence=DAA04641.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR1G1 Gene

Post-translational modifications for OR1G1 Gene

Other Protein References for OR1G1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1G1 Gene

Domains & Families for OR1G1 Gene

Gene Families for OR1G1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1G1 Gene

Suggested Antigen Peptide Sequences for OR1G1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1G1: view

Function for OR1G1 Gene

Molecular function for OR1G1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily G,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR1G1 Gene

Gene Ontology (GO) - Molecular Function for OR1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1G1: view
genes like me logo Genes that share phenotypes with OR1G1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1G1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1G1 Gene

Localization for OR1G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1G1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1G1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1G1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1G1 Gene

Pathways & Interactions for OR1G1 Gene

genes like me logo Genes that share pathways with OR1G1: view

Pathways by source for OR1G1 Gene

1 KEGG pathway for OR1G1 Gene

Gene Ontology (GO) - Biological Process for OR1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8004088
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR1G1: view

No data available for SIGNOR curated interactions for OR1G1 Gene

Drugs & Compounds for OR1G1 Gene

No Compound Related Data Available

Transcripts for OR1G1 Gene

mRNA/cDNA for OR1G1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1G1 Gene

Olfactory receptor, family 1, subfamily G, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1G1

Alternative Splicing Database (ASD) splice patterns (SP) for OR1G1 Gene

No ASD Table

Relevant External Links for OR1G1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1G1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1G1 Gene

This gene is overexpressed in Testis (x9.7) and Bladder (x8.0).

NURSA nuclear receptor signaling pathways regulating expression of OR1G1 Gene:


SOURCE GeneReport for Unigene cluster for OR1G1 Gene:

genes like me logo Genes that share expression patterns with OR1G1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1G1 Gene

Orthologs for OR1G1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1G1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR1G1 34 33
  • 98.3 (n)
(Bos Taurus)
Mammalia OR1G1 34 33
  • 83.44 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
OPOR43 34
  • 64 (a)
(Rattus norvegicus)
Mammalia Olr1406 33
  • 64 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
(Mus musculus)
Mammalia Olfr1324 34
  • 49 (a)
Or1o1 51 Olfr107
  • chr17:37,405,550-37,406,476
Or1t1 51 Olfr108
  • chr17:37,445,523-37,446,482
Or1w1 51 Olfr97
  • chr17:37,231,439-37,232,368
Or1w3 51 Olfr99
  • chr17:37,279,504-37,280,418
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731992 33
  • 55.59 (n)
Species where no ortholog for OR1G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1G1 Gene

Gene Tree for OR1G1 (if available)
Gene Tree for OR1G1 (if available)
Evolutionary constrained regions (ECRs) for OR1G1: view image

Paralogs for OR1G1 Gene

Paralogs for OR1G1 Gene

(454) SIMAP similar genes for OR1G1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1G1: view

Variants for OR1G1 Gene

Sequence variations from dbSNP and Humsavar for OR1G1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000043329 -- 3,129,234(-) C/A upstream_transcript_variant
rs1000617243 -- 3,127,726(-) A/G upstream_transcript_variant
rs1001622772 -- 3,126,495(-) A/G/T downstream_transcript_variant
rs1002474205 -- 3,126,771(-) T/C coding_sequence_variant, missense_variant
rs1004465806 -- 3,128,553(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR1G1 Gene

Variant ID Type Subtype PubMed ID
dgv3084n100 CNV loss 25217958
dgv4n29 CNV loss 16826518
esv2660206 CNV deletion 23128226
nsv1056184 CNV loss 25217958
nsv1060926 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv7288 OTHER inversion 18451855

Variation tolerance for OR1G1 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1G1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1G1 Gene

Disorders for OR1G1 Gene

Additional Disease Information for OR1G1

No disorders were found for OR1G1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1G1 Gene

Publications for OR1G1 Gene

  1. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N … Lehrach H (Human molecular genetics 1994) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G … Lancet D (Genomics 2000) 3 4 58
  5. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 58

Products for OR1G1 Gene

Sources for OR1G1 Gene

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