Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1F12 Gene

Aliases for OR1F12 Gene

  • Olfactory Receptor Family 1 Subfamily F Member 12 2 3 5
  • Hs6M1-35P 2 3 4
  • Olfactory Receptor 1F12 3 4
  • OR1F12P 3 4
  • OR1F12Q 2 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 12 Pseudogene 2
  • Olfactory Receptor, Family 1, Subfamily F, Member 12 2
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor OR6-12 3
  • OR6-12 3
  • OR1F12 5

External Ids for OR1F12 Gene

Previous HGNC Symbols for OR1F12 Gene

  • OR1F12P

Previous GeneCards Identifiers for OR1F12 Gene

  • GC00U990906
  • GC06P028148
  • GC06P028044

Summaries for OR1F12 Gene

Entrez Gene Summary for OR1F12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1F12 Gene

OR1F12 (Olfactory Receptor Family 1 Subfamily F Member 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot Summary for OR1F12 Gene

Additional gene information for OR1F12 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1F12 Gene

Genomics for OR1F12 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1F12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J028060 Enhancer 0.5 Ensembl 0.4 -12.6 -12615 0.2 ZNF316 NFE2 MAFG MAFK MAFF EMSY ZNF602P OR2B8P piR-32285-079 OR1F12 ZSCAN16-AS1 OR2B6
GH06J028003 Enhancer 0.6 Ensembl 0.2 -68.4 -68415 3 ATF2 FOXA2 YY1 ETV1 ZBTB21 MEIS2 ZMYM3 ZNF629 ZNF692 DACH1 piR-35002-054 ZNF603P ZNF165 OR2B8P piR-46501-085 OR2B6 OR1F12
GH06J027977 Enhancer 0.3 Ensembl 0.2 -85.9 -85943 0.9 PRDM1 PKNOX1 ZNF602P ENSG00000199851 ZNF165 COX11P1 ZSCAN23 OR2E1P ZNF603P piR-46501-085 OR2W4P OR2B6
GH06J028010 Enhancer 0.3 Ensembl 0.2 -61.8 -61815 0.6 FOXA2 IQCB2P lnc-OR2B6-1 ZNF165 ZNF603P ZNF602P ENSG00000199851 OR2B6 OR1F12 ZSCAN16-AS1
GH06J028008 Enhancer 0.2 Ensembl 0.2 -64.5 -64515 0.4 IQCB2P piR-35002-054 lnc-OR2B6-1 ZNF165 OR2B6 OR1F12 ZSCAN16-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1F12 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1F12

Genomic Locations for OR1F12 Gene

Latest Assembly
chr6:28,073,316-28,074,329
(GRCh38/hg38)
Size:
1,014 bases
Orientation:
Plus strand

Previous Assembly
chr6:28,041,094-28,042,107
(GRCh37/hg19 by Entrez Gene)
Size:
1,014 bases
Orientation:
Plus strand

chr6:28,041,094-28,042,011
(GRCh37/hg19 by Ensembl)
Size:
918 bases
Orientation:
Plus strand

Genomic View for OR1F12 Gene

Genes around OR1F12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1F12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1F12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1F12 Gene

Proteins for OR1F12 Gene

  • Protein details for OR1F12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHA8-OR1FC_HUMAN
    Recommended name:
    Olfactory receptor 1F12
    Protein Accession:
    Q8NHA8

    Protein attributes for OR1F12 Gene

    Size:
    337 amino acids
    Molecular mass:
    36933 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1F12 Gene

Post-translational modifications for OR1F12 Gene

  • Glycosylation at Asn5, Asn8, and Asn265

Other Protein References for OR1F12 Gene

REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1F12 Gene

Domains & Families for OR1F12 Gene

Gene Families for OR1F12 Gene

Protein Domains for OR1F12 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1F12 Gene

GenScript: Design optimal peptide antigens:
  • OR1F12 (D2XT26_HUMAN)
  • OR1F12 (D2XT28_HUMAN)
  • Hs6M1-35P (OR1FC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHA8

UniProtKB/Swiss-Prot:

OR1FC_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1F12: view

Function for OR1F12 Gene

Molecular function for OR1F12 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR1F12 Gene

Gene Ontology (GO) - Molecular Function for OR1F12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR1F12: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1F12 Gene

Localization for OR1F12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1F12 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR1F12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1F12: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR1F12 Gene

Pathways & Interactions for OR1F12 Gene

genes like me logo Genes that share pathways with OR1F12: view

Pathways by source for OR1F12 Gene

Interacting Proteins for OR1F12 Gene

Selected Interacting proteins: Q8NHA8-OR1FC_HUMAN for OR1F12 Gene via IID

Symbol External ID(s) Details
NLGN3

Gene Ontology (GO) - Biological Process for OR1F12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1F12: view

No data available for SIGNOR curated interactions for OR1F12 Gene

Drugs & Compounds for OR1F12 Gene

No Compound Related Data Available

Transcripts for OR1F12 Gene

mRNA/cDNA for OR1F12 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR1F12 Gene

No ASD Table

Relevant External Links for OR1F12 Gene

GeneLoc Exon Structure for
OR1F12

Expression for OR1F12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1F12 Gene

mRNA differential expression in normal tissues according to GTEx for OR1F12 Gene

This gene is overexpressed in Testis (x10.3).
genes like me logo Genes that share expression patterns with OR1F12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1F12 Gene

Orthologs for OR1F12 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OR1F12 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Or1f12 45 Olfr1366
  • chr13:21,537,020-21,538,063
Species where no ortholog for OR1F12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1F12 Gene

ENSEMBL:
Gene Tree for OR1F12 (if available)
TreeFam:
Gene Tree for OR1F12 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR1F12

Paralogs for OR1F12 Gene

(460) SIMAP similar genes for OR1F12 Gene using alignment to 3 proteins:

  • OR1FC_HUMAN
  • D2XT26_HUMAN
  • D2XT28_HUMAN
genes like me logo Genes that share paralogs with OR1F12: view

No data available for Paralogs for OR1F12 Gene

Variants for OR1F12 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR1F12 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for OR1F12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1F12
Leiden Open Variation Database (LOVD)
OR1F12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR1F12 Gene

Disorders for OR1F12 Gene

Additional Disease Information for OR1F12

No disorders were found for OR1F12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1F12 Gene

Publications for OR1F12 Gene

  1. Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism. (PMID: 25464930) Shen C … Zhong N (Journal of molecular neuroscience : MN 2015) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3

Products for OR1F12 Gene

Sources for OR1F12 Gene