OR1F1 Gene (Protein Coding)

Olfactory Receptor Family 1 Subfamily F Member 1

GC16P005003
GIFtS:
33
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1F1 Gene

Aliases for OR1F1 Gene

  • Olfactory Receptor Family 1 Subfamily F Member 1 2 3 5
  • OLFMF 2 3 4
  • Olfactory Receptor 1F1 3 4
  • OR16-36 2 3
  • OR16-37 2 3
  • OR16-88 2 3
  • OR16-89 2 3
  • OR16-90 2 3
  • OR3-145 2 3
  • OR1F10 3 4
  • OR1F4 3 4
  • OR1F5 3 4
  • OR1F6 3 4
  • OR1F7 3 4
  • OR1F8 3 4
  • OR1F9 3 4
  • Olfactory Receptor Family 1 Subfamily F Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 1, Subfamily F, Member 13 Pseudogene 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 10 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 1 2
  • Olfactory Receptor, Family 1, Subfamily F, Member 4 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 5 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 6 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 7 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 9 3
  • Olfactory Receptor OR16-4 4
  • Olfactory Receptor 16-35 4
  • Olfactory Receptor 1F10 4
  • Olfactory Receptor 1F4 4
  • Olfactory Receptor 1F5 4
  • Olfactory Receptor 1F6 4
  • Olfactory Receptor 1F7 4
  • Olfactory Receptor 1F8 4
  • Olfactory Receptor 1F9 4
  • OR1F13P 3
  • ORL1023 3
  • OR16-35 4
  • OR1F1 5
  • Olfmf 2

External Ids for OR1F1 Gene

Previous HGNC Symbols for OR1F1 Gene

  • OR1F4
  • OR1F6
  • OR1F7
  • OR1F8
  • OR1F9
  • OR1F5
  • OR1F10
  • OR1F13P

Previous GeneCards Identifiers for OR1F1 Gene

  • GC16P003274
  • GC16P003255
  • GC16P003256
  • GC16P003195
  • GC16P003257
  • GC16P003260
  • GC16P003269
  • GC16P003218
  • GC16P003249
  • GC16P003771
  • GC16P003849
  • GC16P003899
  • GC16P004074
  • GC16P003288
  • GC16P003326
  • GC16P003352
  • GC16P003399
  • GC16P003446
  • GC16P003481
  • GC16P003569
  • GC16P003615
  • GC16P004261
  • GC16P004504

Summaries for OR1F1 Gene

Entrez Gene Summary for OR1F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1F1 Gene

OR1F1 (Olfactory Receptor Family 1 Subfamily F Member 1) is a Protein Coding gene. Diseases associated with OR1F1 include Hirschsprung Disease 1. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1J4.

UniProtKB/Swiss-Prot Summary for OR1F1 Gene

Gene Wiki entry for OR1F1 Gene

Additional gene information for OR1F1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1F1 Gene

Genomics for OR1F1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR1F1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16J003187 Promoter/Enhancer 1.3 Ensembl ENCODE 250.7 +0.7 697 3 BCLAF1 IKZF1 ZNF580 ZNF592 ZSCAN16 NFIC ZIC2 CHD4 ZBTB10 TARDBP ENSG00000262668 OR1F1 TRP-AGG2-8 TRP-TGG3-5 ZNF205 MTCO1P28 ZNF75A ZNF263 ZNF213-AS1 AMDHD2
GH16J003105 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.4 -81.8 -81779 2.4 BCLAF1 ZNF600 MYC ZNF580 ZNF592 POLR2A CEBPA NFIC ZBTB10 MXD4 ENSG00000263011 HSALNG0109124 lnc-ZSCAN10-6 ZNF205 ZNF213-AS1 OR2C1 OR1F1 CLUAP1 PAQR4 ZSCAN10
GH16J003097 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.6 -88.1 -88118 6.2 ZNF654 ZNF600 POLR2A ZIC2 YY1 CTCF ETS1 TRIM22 BHLHE40 TBP ZSCAN10 HSALNG0109121 HSALNG0109123 ZNF205 ZNF213-AS1 CLDN6 TNFRSF12A ZNF205-AS1 ZNF213 ZNF263
GH16J003296 Enhancer 0.4 FANTOM5 7 +107.3 107333 0.2 POLR2A RBFOX2 OR2C1 ZNF263 ZNF200 MEFV ZNF174 ZSCAN32 C16orf90 OR1F1 SLX4 CLUAP1
GH16J003462 Enhancer 0.2 FANTOM5 9.3 +274.0 274019 0.3 OR1F1 OR2C1 CLUAP1 TIGD7 ENSG00000263212 RF00017-1724 NAA60 C16orf90 ENSG00000285329
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1F1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1F1

Top Transcription factor binding sites by QIAGEN in the OR1F1 gene promoter:
  • HNF-4alpha1
  • LUN-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR1F1 Gene

Latest Assembly
chr16:3,188,204-3,206,556
(GRCh38/hg38)
Size:
18,353 bases
Orientation:
Plus strand

Previous Assembly
chr16:3,238,204-3,256,556
(GRCh37/hg19 by Entrez Gene)
Size:
18,353 bases
Orientation:
Plus strand

chr16:3,254,247-3,255,188
(GRCh37/hg19 by Ensembl)
Size:
942 bases
Orientation:
Plus strand

Genomic View for OR1F1 Gene

Genes around OR1F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1F1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR1F1 Gene

Proteins for OR1F1 Gene

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  • Protein details for OR1F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43749-OR1F1_HUMAN
    Recommended name:
    Olfactory receptor 1F1
    Protein Accession:
    O43749
    Secondary Accessions:
    • O15246
    • Q6IFL5

    Protein attributes for OR1F1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1F1 Gene

Post-translational modifications for OR1F1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1F1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1F1 Gene

Domains & Families for OR1F1 Gene

Gene Families for OR1F1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1F1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1F1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor (O43871_HUMAN)
  • Olfactory receptor (O43872_HUMAN)
  • Olfactory receptor (O43873_HUMAN)
  • Olfactory receptor (O43874_HUMAN)
  • Olfactory receptor (O43875_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43749

UniProtKB/Swiss-Prot:

OR1F1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1F1: view

Function for OR1F1 Gene

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Molecular function for OR1F1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily F,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR1F1 Gene

Gene Ontology (GO) - Molecular Function for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR1F1: view
genes like me logo Genes that share phenotypes with OR1F1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1F1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1F1 Gene

Localization for OR1F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1F1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1F1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1F1 Gene

Pathways & Interactions for OR1F1 Gene

genes like me logo Genes that share pathways with OR1F1: view

Pathways by source for OR1F1 Gene

2 BioSystems pathways for OR1F1 Gene
1 KEGG pathway for OR1F1 Gene

Interacting Proteins for OR1F1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000305424 O43749-OR1F1_HUMAN for OR1F1 Gene via STRING IID

GPS-Prot Interaction Network for OR1F1

Gene Ontology (GO) - Biological Process for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9500546
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1F1: view

No data available for SIGNOR curated interactions for OR1F1 Gene

Drugs & Compounds for OR1F1 Gene

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No Compound Related Data Available

Transcripts for OR1F1 Gene

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mRNA/cDNA for OR1F1 Gene

4 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1F1

Alternative Splicing Database (ASD) splice patterns (SP) for OR1F1 Gene

No ASD Table

Relevant External Links for OR1F1 Gene

GeneLoc Exon Structure for
OR1F1

Expression for OR1F1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1F1 Gene

mRNA expression in normal human tissues for OR1F1 Gene
mRNA expression by GTEx for OR1F1 GenemRNA expression by BioGPS for OR1F1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1F1 Gene

This gene is overexpressed in Brain - Cerebellum (x11.8) and Brain - Cerebellar Hemisphere (x10.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1F1

SOURCE GeneReport for Unigene cluster for OR1F1 Gene:

Hs.664502
genes like me logo Genes that share expression patterns with OR1F1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1F1 Gene

Orthologs for OR1F1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1F1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
 Mammalia LOC539468 29
  • 86.34 (n)
-- 30
  • 83 (a)
 OneToMany
-- 30
  • 82 (a)
 OneToMany
-- 30
  • 79 (a)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Olr1378 29
  • 82.64 (n)
Mouse
(Mus musculus)
 Mammalia Or1f19 45 Olfr161 30
  • 73 (a)
 OneToOne
Or1ad1 45 Olfr1377
  • chr11:50,984,703-50,985,623
Or1ad5-ps 45 Olfr1376-ps1
  • chr11:50,991,792-50,992,740
Or1ad6 45 Olfr1378
  • chr11:50,969,020-50,969,964
Or1f20-ps 45 Olfr162-ps1
  • chr16:3,601,922-3,602,862
Or1f21-ps 45 Olfr163-ps1
  • chr16:3,618,089-3,618,869
Oppossum
(Monodelphis domestica)
 Mammalia OR1F1 30
  • 71 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia OR10A11 30
  • 61 (a)
 OneToMany
Species where no ortholog for OR1F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1F1 Gene

ENSEMBL:
Gene Tree for OR1F1 (if available)
TreeFam:
Gene Tree for OR1F1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1F1: view image
Alliance of Genome Resources:
Additional Orthologs for OR1F1

Paralogs for OR1F1 Gene

Paralogs for OR1F1 Gene

(455) SIMAP similar genes for OR1F1 Gene using alignment to 1 proteins:

  • OR1F1_HUMAN

Pseudogenes.org Pseudogenes for OR1F1 Gene

genes like me logo Genes that share paralogs with OR1F1: view

Variants for OR1F1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1F1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs142486394 Likely Benign: Hirschsprung disease 1 3,204,293(+) G/A
NM_012360.2(OR1F1):c.47G>A (p.Gly16Glu) 		MISSENSE
rs61731433 Benign: not provided 3,204,424(+) T/C
NM_012360.2(OR1F1):c.178T>C (p.Tyr60His) 		MISSENSE
rs61731440 Benign: not provided 3,204,611(+) A/G
NM_012360.2(OR1F1):c.365A>G (p.His122Arg) 		MISSENSE
rs8045183 Benign: not provided 3,204,622(+) G/Ap.Val126Met
NM_012360.2(OR1F1):c.376G>A (p.Val126Met) 		MISSENSE
rs1834026 -- p.Phe75Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR1F1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR1F1 Gene

Variant ID Type Subtype PubMed ID
esv3581941 CNV loss 25503493
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958
nsv1713 CNV insertion 18451855
nsv457355 CNV gain 19166990
nsv471074 CNV gain 18288195
nsv524873 CNV loss 19592680
nsv571249 CNV gain 21841781
nsv833127 CNV gain+loss 17160897

Variation tolerance for OR1F1 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.99; 92.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1F1
Leiden Open Variation Database (LOVD)
OR1F1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1F1 Gene

Disorders for OR1F1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR1F1 Gene - From: GCD

Disorder Aliases PubMed IDs
hirschsprung disease 1
  • hirschsprung disease, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search OR1F1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR1F1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OR1F1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR1F1 Gene

Publications for OR1F1 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4
  2. A candidate gene for familial Mediterranean fever. (PMID: 9288094) French FMF Consortium (Nature genetics 1997) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4

ExternalLinks

View latest publications for OR1F1 gene in Mastermind

Products for OR1F1 Gene

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