Free for academic non-profit institutions. Other users need a Commercial license
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR1F1 (Olfactory Receptor Family 1 Subfamily F Member 1) is a Protein Coding gene. Diseases associated with OR1F1 include Hirschsprung Disease 1. Among its related pathways are Signaling by GPCR and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1J4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | Peptide ligand-binding receptors | ||
4 | GPCRs, Other |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | NAS | 9500546 |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | LOC539468 30 |
|
||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Olr1378 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or1f19 46 Olfr161 31 |
|
OneToOne |
|
Or1ad1 46 Olfr1377 |
|
|
|||
Or1ad5-ps 46 Olfr1376-ps1 |
|
|
|||
Or1ad6 46 Olfr1378 |
|
|
|||
Or1f20-ps 46 Olfr162-ps1 |
|
|
|||
Or1f21-ps 46 Olfr163-ps1 |
|
|
|||
Oppossum (Monodelphis domestica) |
Mammalia | OR1F1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | OR10A11 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
776969 | Benign: not provided | 3,204,622(+) | G/A | MISSENSE_VARIANT | |
781181 | Benign: not provided | 3,204,424(+) | T/C | MISSENSE_VARIANT | |
788677 | Benign: not provided | 3,204,611(+) | A/G | MISSENSE_VARIANT | |
rs142486394 | Likely Benign: Hirschsprung disease 1 | 3,204,293(+) | G/A | MISSENSE_VARIANT | |
rs1834026 | - | p.Phe75Ser |
Disorder | Aliases | PubMed IDs |
---|---|---|
hirschsprung disease 1 |
|
|