Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1E2 Gene

Aliases for OR1E2 Gene

  • Olfactory Receptor Family 1 Subfamily E Member 2 2 3 5
  • OR17-135 2 3 4
  • OR17-93 2 3 4
  • Olfactory Receptor 17-93/17-135/17-136 3 4
  • Olfactory Receptor 1E2 3 4
  • Olfactory Receptor 1E4 3 4
  • OR17-136 3 4
  • OR1E4 3 4
  • Olfactory Receptor, Family 1, Subfamily E, Member 2 2
  • Olfactory Receptor, Family 1, Subfamily E, Member 4 3
  • Olfactory Receptor, Family 1, Subfamily E, Member 7 3
  • Olfactory Receptor OR17-17 3
  • Olfactory Receptor OR17-3 3
  • OST529 3
  • OR1E7 3
  • OR1E2 5

External Ids for OR1E2 Gene

Previous HGNC Symbols for OR1E2 Gene

  • OR1E4

Previous GeneCards Identifiers for OR1E2 Gene

  • GC17M003650
  • GC17M003286
  • GC17M003542
  • GC17M003282
  • GC17M003336

Summaries for OR1E2 Gene

Entrez Gene Summary for OR1E2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1E2 Gene

OR1E2 (Olfactory Receptor Family 1 Subfamily E Member 2) is a Protein Coding gene. Diseases associated with OR1E2 include Aicardi Syndrome and Fructose Intolerance, Hereditary. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is OR1E1.

UniProtKB/Swiss-Prot Summary for OR1E2 Gene

Gene Wiki entry for OR1E2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1E2 Gene

Genomics for OR1E2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1E2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003528 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -96.4 -96360 4.4 ZMYM3 ZFP64 KDM6A SMAD4 SAP130 YY1 DMAP1 TEAD3 BCL6 ZNF205 lnc-SPATA22-1 TRPV3 ASPA OR1E2 CAMKK1 TRPV1 RF00017-2006 SPATA22 MG828730-025 MK280269-020
GH17J003386 Promoter/Enhancer 0.7 FANTOM5 Ensembl 10.9 +47.4 47440 0.8 POLR2A OR1R1P OR3A2 lnc-OR3A2-1 piR-57460-264 SPATA22 ASPA OR3A3 OR1E2 OR3A1 OR1E1
GH17J003885 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.5 -456.7 -456695 10.9 SP1 ZNF207 ZNF600 MYC JUND ZNF580 ZNF592 ATF2 KLF9 ZNF223 CAMKK1 ANKFY1 MYBBP1A ENSG00000235085 PELP1 P2RX1 SHPK NCBP3 ZZEF1 ENSG00000262903
GH17J003167 Enhancer 0.6 Ensembl ENCODE 9.8 +266.0 266040 1.2 PRDM1 IRF4 IKZF1 SPI1 IKZF2 OR1A2 OR1E2 HSALNG0113951 LOC100288728 OR1P1 OR1G1
GH17J003518 Enhancer 0.5 dbSUPER 10.4 -85.3 -85266 1.5 HES1 CTBP1 YBX1 HDGF HDAC2 ZNF366 ZBTB17 IKZF1 GATAD2B OR1E2 OR1E1 SPATA22 lnc-SPATA22-1 TRPV3 HSALNG0113961 MK280269-020 MG828730-025
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1E2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1E2

Top Transcription factor binding sites by QIAGEN in the OR1E2 gene promoter:
  • AML1a
  • GATA-2
  • GCNF
  • GCNF-1
  • GCNF-2
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha2
  • SRF
  • SRF (504 AA)

Genomic Locations for OR1E2 Gene

Latest Assembly
chr17:3,432,870-3,433,841
(GRCh38/hg38)
Size:
972 bases
Orientation:
Minus strand

Previous Assembly
chr17:3,336,164-3,337,135
(GRCh37/hg19 by Entrez Gene)
Size:
972 bases
Orientation:
Minus strand

chr17:3,336,164-3,337,135
(GRCh37/hg19 by Ensembl)
Size:
972 bases
Orientation:
Minus strand

Genomic View for OR1E2 Gene

Genes around OR1E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1E2 Gene

Proteins for OR1E2 Gene

  • Protein details for OR1E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47887-OR1E2_HUMAN
    Recommended name:
    Olfactory receptor 1E2
    Protein Accession:
    P47887
    Secondary Accessions:
    • O43877
    • O95632
    • Q0VAD5
    • Q0VAD6
    • Q9UL13

    Protein attributes for OR1E2 Gene

    Size:
    323 amino acids
    Molecular mass:
    36391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1E2 Gene

Post-translational modifications for OR1E2 Gene

  • Glycosylation at Asn5 and Asn274
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1E2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1E2 Gene

Domains & Families for OR1E2 Gene

Gene Families for OR1E2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1E2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1E2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 1E4 (OR1E2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47887

UniProtKB/Swiss-Prot:

OR1E2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1E2: view

Function for OR1E2 Gene

Molecular function for OR1E2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily E,member 2,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0038023 signaling receptor activity TAS 8004088
genes like me logo Genes that share ontologies with OR1E2: view
genes like me logo Genes that share phenotypes with OR1E2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1E2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1E2 Gene

Localization for OR1E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1E2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1E2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8004088
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1E2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1E2 Gene

Pathways & Interactions for OR1E2 Gene

genes like me logo Genes that share pathways with OR1E2: view

Pathways by source for OR1E2 Gene

1 KEGG pathway for OR1E2 Gene

Interacting Proteins for OR1E2 Gene

Gene Ontology (GO) - Biological Process for OR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8004088
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007606 sensory perception of chemical stimulus TAS 8004088
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR1E2: view

No data available for SIGNOR curated interactions for OR1E2 Gene

Drugs & Compounds for OR1E2 Gene

No Compound Related Data Available

Transcripts for OR1E2 Gene

mRNA/cDNA for OR1E2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1E2

Alternative Splicing Database (ASD) splice patterns (SP) for OR1E2 Gene

No ASD Table

Relevant External Links for OR1E2 Gene

GeneLoc Exon Structure for
OR1E2

Expression for OR1E2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1E2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1E2

SOURCE GeneReport for Unigene cluster for OR1E2 Gene:

Hs.533931
genes like me logo Genes that share expression patterns with OR1E2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1E2 Gene

Orthologs for OR1E2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1E2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PTOR1E2 29
  • 98.51 (n)
PTR203 30
  • 98 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1466 29
  • 84.79 (n)
Mouse
(Mus musculus)
Mammalia Olfr20 29 16 30
  • 84.47 (n)
ManyToMany
Olfr376 30
  • 82 (a)
ManyToMany
Olfr1 30
  • 81 (a)
ManyToMany
Olfr378 30
  • 77 (a)
ManyToMany
Olfr390 30
  • 77 (a)
ManyToMany
Olfr389 30
  • 76 (a)
ManyToMany
Olfr392 30
  • 75 (a)
ManyToMany
Olfr395 30
  • 75 (a)
ManyToMany
Olfr393 30
  • 74 (a)
ManyToMany
Olfr384 30
  • 74 (a)
ManyToMany
Olfr394 30
  • 74 (a)
ManyToMany
Olfr23 30
  • 73 (a)
ManyToMany
Olfr385 30
  • 72 (a)
ManyToMany
Olfr382 30
  • 71 (a)
ManyToMany
Olfr380 30
  • 71 (a)
ManyToMany
Olfr381 30
  • 71 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia OR1E2 30
  • 84 (a)
ManyToMany
DTMT 30
  • 83 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia OR1E1 29
  • 83.06 (n)
-- 30
  • 83 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 81 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia OPOR52 30
  • 75 (a)
OneToMany
Species where no ortholog for OR1E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1E2 Gene

ENSEMBL:
Gene Tree for OR1E2 (if available)
TreeFam:
Gene Tree for OR1E2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1E2: view image
Alliance of Genome Resources:
Additional Orthologs for OR1E2

Paralogs for OR1E2 Gene

(454) SIMAP similar genes for OR1E2 Gene using alignment to 1 proteins:

  • OR1E2_HUMAN
genes like me logo Genes that share paralogs with OR1E2: view

Variants for OR1E2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1E2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
VAR_036207 A colorectal cancer sample p.His168Asp
rs769431 -- p.Cys27Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR1E2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR1E2 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv3892950 CNV loss 25118596
nsv1055740 CNV gain 25217958
nsv1059413 CNV loss 25217958
nsv1060071 CNV loss 25217958
nsv1065489 CNV gain 25217958
nsv521277 CNV gain 19592680
nsv574232 CNV gain 21841781
nsv574236 CNV gain 21841781
nsv833341 CNV loss 17160897

Variation tolerance for OR1E2 Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.37; 70.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1E2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1E2
Leiden Open Variation Database (LOVD)
OR1E2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1E2 Gene

Disorders for OR1E2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR1E2 Gene - From: COP

Disorder Aliases PubMed IDs
aicardi syndrome
  • aic
fructose intolerance, hereditary
  • hfi
- elite association - COSMIC cancer census association via MalaCards
Search OR1E2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR1E2

genes like me logo Genes that share disorders with OR1E2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR1E2 Gene

Publications for OR1E2 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4
  2. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N … Lehrach H (Human molecular genetics 1994) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  5. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G … Lancet D (Genomics 2000) 3 4

Products for OR1E2 Gene

Sources for OR1E2 Gene