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Aliases for OR1E2 Gene

Aliases for OR1E2 Gene

  • Olfactory Receptor Family 1 Subfamily E Member 2 2 3 5
  • Olfactory Receptor 17-93/17-135/17-136 3 4
  • Olfactory Receptor 1E4 3 4
  • OR17-135 3 4
  • OR17-136 3 4
  • OR17-93 3 4
  • OR1E4 3 4
  • Olfactory Receptor, Family 1, Subfamily E, Member 2 2
  • Olfactory Receptor, Family 1, Subfamily E, Member 4 3
  • Olfactory Receptor, Family 1, Subfamily E, Member 7 3
  • Olfactory Receptor OR17-17 3
  • Olfactory Receptor OR17-3 3
  • Olfactory Receptor 1E2 3
  • OST529 3
  • OR1E7 3

External Ids for OR1E2 Gene

Previous HGNC Symbols for OR1E2 Gene

  • OR1E4

Previous GeneCards Identifiers for OR1E2 Gene

  • GC17M003650
  • GC17M003286
  • GC17M003542
  • GC17M003282
  • GC17M003336

Summaries for OR1E2 Gene

Entrez Gene Summary for OR1E2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1E2 Gene

OR1E2 (Olfactory Receptor Family 1 Subfamily E Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is OR1E1.

UniProtKB/Swiss-Prot for OR1E2 Gene

  • Odorant receptor.

Gene Wiki entry for OR1E2 Gene

Additional gene information for OR1E2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1E2 Gene

Genomics for OR1E2 Gene

GeneHancer (GH) Regulatory Elements for OR1E2 Gene

Promoters and enhancers for OR1E2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I003528 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -96.6 -96568 3.8 SOX13 TFAP4 KLF1 SAP130 ZFP64 ARID4B ZMYM3 DMAP1 ZNF644 TEAD3 TRPV3 ASPA OR1E2 CAMKK1 TRPV1 GC17M003518 SPATA22
GH17I003167 Enhancer 0.7 Ensembl ENCODE 9.8 +266.0 266043 0.8 IKZF1 IKZF2 PRDM1 IRF4 SPI1 OR1A2 OR1E2 LOC100288728 OR1P1 GC17P003146
GH17I003885 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.5 -456.7 -456695 10.9 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZNF213 CAMKK1 ANKFY1 MYBBP1A PELP1 ENSG00000235085 LOC105371492 ZZEF1 P2RX1 SHPK NCBP3
GH17I003518 Enhancer 0.6 dbSUPER 10.4 -85.3 -85266 1.5 HDGF YBX1 GATAD2B CTBP1 ZNF366 HDAC2 IKZF1 HES1 ZBTB17 OR1E2 OR1E1 SPATA22 GC17M003518 TRPV3
GH17I003386 Enhancer 0.5 FANTOM5 10.9 +47.5 47529 0.4 POLR2A EZH2 OR3A1 OR1R1P OR3A2 SPATA22 ASPA OR3A3 OR1E2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR1E2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR1E2 gene promoter:

Genomic Locations for OR1E2 Gene

Genomic Locations for OR1E2 Gene
chr17:3,432,870-3,433,841
(GRCh38/hg38)
Size:
972 bases
Orientation:
Minus strand
chr17:3,336,164-3,337,135
(GRCh37/hg19)

Genomic View for OR1E2 Gene

Genes around OR1E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1E2 Gene

Proteins for OR1E2 Gene

  • Protein details for OR1E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47887-OR1E2_HUMAN
    Recommended name:
    Olfactory receptor 1E2
    Protein Accession:
    P47887
    Secondary Accessions:
    • O43877
    • O95632
    • Q0VAD5
    • Q0VAD6
    • Q9UL13

    Protein attributes for OR1E2 Gene

    Size:
    323 amino acids
    Molecular mass:
    36391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1E2 Gene

Post-translational modifications for OR1E2 Gene

  • Glycosylation at isoforms=5 and isoforms=274
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1E2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1E2 Gene

Domains & Families for OR1E2 Gene

Gene Families for OR1E2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1E2 Gene

Suggested Antigen Peptide Sequences for OR1E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47887

UniProtKB/Swiss-Prot:

OR1E2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1E2: view

Function for OR1E2 Gene

Molecular function for OR1E2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily E,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8004088
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1E2: view

Phenotypes for OR1E2 Gene

genes like me logo Genes that share phenotypes with OR1E2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1E2 Gene

Localization for OR1E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1E2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1E2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8004088
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1E2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1E2 Gene

Pathways & Interactions for OR1E2 Gene

genes like me logo Genes that share pathways with OR1E2: view

Pathways by source for OR1E2 Gene

1 KEGG pathway for OR1E2 Gene

Interacting Proteins for OR1E2 Gene

Gene Ontology (GO) - Biological Process for OR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8004088
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007606 sensory perception of chemical stimulus TAS 8004088
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR1E2: view

No data available for SIGNOR curated interactions for OR1E2 Gene

Drugs & Compounds for OR1E2 Gene

No Compound Related Data Available

Transcripts for OR1E2 Gene

mRNA/cDNA for OR1E2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1E2 Gene

Olfactory receptor, family 1, subfamily E, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1E2 Gene

No ASD Table

Relevant External Links for OR1E2 Gene

GeneLoc Exon Structure for
OR1E2
ECgene alternative splicing isoforms for
OR1E2

Expression for OR1E2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1E2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1E2 Gene:

OR1E2

SOURCE GeneReport for Unigene cluster for OR1E2 Gene:

Hs.533931
genes like me logo Genes that share expression patterns with OR1E2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1E2 Gene

Orthologs for OR1E2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1E2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTOR1E2 33
  • 98.51 (n)
PTR203 34
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1466 33
  • 84.79 (n)
mouse
(Mus musculus)
Mammalia Olfr20 33 16 34
  • 84.47 (n)
Olfr376 34
  • 82 (a)
ManyToMany
Olfr1 34
  • 81 (a)
ManyToMany
Olfr378 34
  • 77 (a)
ManyToMany
Olfr390 34
  • 77 (a)
ManyToMany
Olfr389 34
  • 76 (a)
ManyToMany
Olfr392 34
  • 75 (a)
ManyToMany
Olfr395 34
  • 75 (a)
ManyToMany
Olfr384 34
  • 74 (a)
ManyToMany
Olfr393 34
  • 74 (a)
ManyToMany
Olfr394 34
  • 74 (a)
ManyToMany
Olfr23 34
  • 73 (a)
ManyToMany
Olfr385 34
  • 72 (a)
ManyToMany
Olfr380 34
  • 71 (a)
ManyToMany
Olfr381 34
  • 71 (a)
ManyToMany
Olfr382 34
  • 71 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia OR1E2 34
  • 84 (a)
ManyToMany
DTMT 34
  • 83 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia OR1E1 33
  • 83.06 (n)
-- 34
  • 83 (a)
ManyToMany
-- 34
  • 82 (a)
ManyToMany
-- 34
  • 82 (a)
ManyToMany
-- 34
  • 82 (a)
ManyToMany
-- 34
  • 82 (a)
ManyToMany
-- 34
  • 82 (a)
ManyToMany
-- 34
  • 81 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia OPOR52 34
  • 75 (a)
OneToMany
Species where no ortholog for OR1E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1E2 Gene

ENSEMBL:
Gene Tree for OR1E2 (if available)
TreeFam:
Gene Tree for OR1E2 (if available)

Paralogs for OR1E2 Gene

Paralogs for OR1E2 Gene

(454) SIMAP similar genes for OR1E2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1E2: view

Variants for OR1E2 Gene

Sequence variations from dbSNP and Humsavar for OR1E2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
VAR_036207 A colorectal cancer sample p.His168Asp
rs1000160397 -- 3,434,197(-) C/A/G upstream_transcript_variant
rs1002450766 -- 3,432,771(-) A/G downstream_transcript_variant
rs1003704854 -- 3,434,027(-) A/G upstream_transcript_variant
rs1004641270 -- 3,432,375(-) A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR1E2 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv3892950 CNV loss 25118596
nsv1055740 CNV gain 25217958
nsv1059413 CNV loss 25217958
nsv1060071 CNV loss 25217958
nsv1065489 CNV gain 25217958
nsv521277 CNV gain 19592680
nsv574232 CNV gain 21841781
nsv574236 CNV gain 21841781
nsv833341 CNV loss 17160897

Variation tolerance for OR1E2 Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.37; 70.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1E2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1E2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1E2 Gene

Disorders for OR1E2 Gene

Additional Disease Information for OR1E2

No disorders were found for OR1E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1E2 Gene

Publications for OR1E2 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4 58
  2. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N … Lehrach H (Human molecular genetics 1994) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  5. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G … Lancet D (Genomics 2000) 3 4 58

Products for OR1E2 Gene

Sources for OR1E2 Gene

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