Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1E1 Gene

Aliases for OR1E1 Gene

  • Olfactory Receptor Family 1 Subfamily E Member 1 2 3 5
  • OR13-66 2 3 4
  • OR17-32 2 3 4
  • OR17-2 2 3 4
  • Olfactory Receptor-Like Protein HGMP07I 3 4
  • Olfactory Receptor 17-2/17-32 3 4
  • Olfactory Receptor OR17-18 3 4
  • Olfactory Receptor 13-66 3 4
  • Olfactory Receptor 5-85 3 4
  • Olfactory Receptor 1E1 3 4
  • Olfactory Receptor 1E5 3 4
  • Olfactory Receptor 1E6 3 4
  • HGM071 2 3
  • OR1E9P 3 4
  • OR5-85 3 4
  • OR1E5 3 4
  • OR1E6 3 4
  • Olfactory Receptor, Family 1, Subfamily E, Member 8 Pseudogene 3
  • Olfactory Receptor, Family 1, Subfamily E, Member 9 Pseudogene 3
  • Olfactory Receptor, Family 1, Subfamily E, Member 1 2
  • Olfactory Receptor, Family 1, Subfamily E, Member 5 3
  • Olfactory Receptor, Family 1, Subfamily E, Member 6 3
  • Olfactory Receptor OR17-4 3
  • OR1E8P 3
  • OST547 3
  • OR1E1 5

External Ids for OR1E1 Gene

Previous HGNC Symbols for OR1E1 Gene

  • OR1E9P
  • OR1E5
  • OR1E6

Previous GeneCards Identifiers for OR1E1 Gene

  • GC17M003614
  • GC17M003251
  • GC17M003510
  • GC17M003511
  • GC17M003247
  • GC17M003300

Summaries for OR1E1 Gene

Entrez Gene Summary for OR1E1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1E1 Gene

OR1E1 (Olfactory Receptor Family 1 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with OR1E1 include Plasminogen Deficiency, Type I and Pseudobulbar Palsy. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1E2.

UniProtKB/Swiss-Prot Summary for OR1E1 Gene

Gene Wiki entry for OR1E1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1E1 Gene

Genomics for OR1E1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1E1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003482 Enhancer 0.5 Ensembl ENCODE 12.3 -84.9 -84891 2.2 POU5F1 NANOG HSALNG0113961 OR1E1 ASPA SPATA22 HSALNG0113960 MG828730-025 MK280269-020
GH17J003518 Enhancer 0.5 dbSUPER 5.8 -120.7 -120697 1.5 HES1 CTBP1 YBX1 HDGF HDAC2 ZNF366 ZBTB17 IKZF1 GATAD2B OR1E2 OR1E1 SPATA22 lnc-SPATA22-1 TRPV3 HSALNG0113961 MK280269-020 MG828730-025
GH17J003486 Enhancer 0.3 Ensembl 9.7 -89.6 -89591 1.2 ATF4 ASPA OR1E1 HSALNG0113961 piR-50437-259 piR-48209-262 SPATA22 MG828730-025 MK280269-020
GH17J003489 Enhancer 0.2 Ensembl 5.2 -91.3 -91291 1 ASPA OR1E1 PAFAH1B1 piR-50437-259 HSALNG0113961 piR-48209-262 SPATA22 MK280269-020 MG828730-025
GH17J003520 Enhancer 0.2 dbSUPER 5.1 -122.9 -122896 0.9 OR1E2 OR1E1 SPATA22 lnc-SPATA22-1 TRPV3 HSALNG0113961 MG828730-025 MK280269-020
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1E1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1E1

Top Transcription factor binding sites by QIAGEN in the OR1E1 gene promoter:
  • AML1a
  • Chx10
  • CUTL1
  • GATA-2
  • p53
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SEF-1 (1)
  • TBP

Genomic Locations for OR1E1 Gene

Latest Assembly
chr17:3,397,104-3,398,410
(GRCh38/hg38)
Size:
1,307 bases
Orientation:
Minus strand

Previous Assembly
chr17:3,300,398-3,301,704
(GRCh37/hg19 by Entrez Gene)
Size:
1,307 bases
Orientation:
Minus strand

chr17:3,300,398-3,301,704
(GRCh37/hg19 by Ensembl)
Size:
1,307 bases
Orientation:
Minus strand

Genomic View for OR1E1 Gene

Genes around OR1E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1E1 Gene

Proteins for OR1E1 Gene

  • Protein details for OR1E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30953-OR1E1_HUMAN
    Recommended name:
    Olfactory receptor 1E1
    Protein Accession:
    P30953
    Secondary Accessions:
    • O43884
    • P47882
    • P47885
    • Q6IFA9
    • Q6IFM5
    • Q9UBJ1
    • Q9UM60

    Protein attributes for OR1E1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35264 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1E1 Gene

Post-translational modifications for OR1E1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1E1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1E1 Gene

Domains & Families for OR1E1 Gene

Gene Families for OR1E1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for OR1E1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1E1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor-like protein HGMP07I (OR1E1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30953

UniProtKB/Swiss-Prot:

OR1E1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1E1: view

Function for OR1E1 Gene

Molecular function for OR1E1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily E,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR1E1 Gene

Gene Ontology (GO) - Molecular Function for OR1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 1370859
genes like me logo Genes that share ontologies with OR1E1: view
genes like me logo Genes that share phenotypes with OR1E1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1E1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR1E1 Gene

Localization for OR1E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1E1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1E1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for OR1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1E1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1E1 Gene

Pathways & Interactions for OR1E1 Gene

genes like me logo Genes that share pathways with OR1E1: view

Pathways by source for OR1E1 Gene

1 KEGG pathway for OR1E1 Gene

Interacting Proteins for OR1E1 Gene

Gene Ontology (GO) - Biological Process for OR1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 1370859
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1E1: view

No data available for SIGNOR curated interactions for OR1E1 Gene

Drugs & Compounds for OR1E1 Gene

No Compound Related Data Available

Transcripts for OR1E1 Gene

mRNA/cDNA for OR1E1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1E1

Alternative Splicing Database (ASD) splice patterns (SP) for OR1E1 Gene

No ASD Table

Relevant External Links for OR1E1 Gene

GeneLoc Exon Structure for
OR1E1

Expression for OR1E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1E1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1E1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.1) and Testis (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1E1

SOURCE GeneReport for Unigene cluster for OR1E1 Gene:

Hs.278485
genes like me logo Genes that share expression patterns with OR1E1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1E1 Gene

Orthologs for OR1E1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1E1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR1E1 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100683843 29
  • 87.03 (n)
OR1E2 30
  • 84 (a)
ManyToMany
DTMT 30
  • 83 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia LOC615901 29
  • 86.41 (n)
-- 30
  • 83 (a)
ManyToMany
-- 30
  • 83 (a)
ManyToMany
-- 30
  • 83 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 81 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Or1e1 45 Olfr20 30
  • 84 (a)
ManyToMany
Or1e1c 45 Olfr376 30
  • 81 (a)
ManyToMany
Or1e16 45 Olfr1 30
  • 80 (a)
ManyToMany
Or1e30 45 Olfr390 30
  • 77 (a)
ManyToMany
Or1e32 45 Olfr392 30
  • 76 (a)
ManyToMany
Or1e29 45 Olfr389 30
  • 76 (a)
ManyToMany
Or1e35 45 Olfr395 30
  • 76 (a)
ManyToMany
Or1e19 45 Olfr378 30
  • 75 (a)
ManyToMany
Or1e34 45 Olfr394 30
  • 75 (a)
ManyToMany
Or1e33 45 Olfr393 30
  • 74 (a)
ManyToMany
Or1e25 45 Olfr384 30
  • 73 (a)
ManyToMany
Or1e17 45 Olfr23 30
  • 73 (a)
ManyToMany
Or1e22 45 Olfr381 30
  • 72 (a)
ManyToMany
Or1e21 45 Olfr380 30
  • 72 (a)
ManyToMany
Or1e23 45 Olfr382 30
  • 72 (a)
ManyToMany
Or1e26 45 Olfr385 30
  • 71 (a)
ManyToMany
Or1e12 45 Olfr397
  • chr11:73,964,553-73,965,554
Or1e18-ps 45 Olfr377-ps1
  • chr11:73,388,084-73,389,024
Or1e1b-ps 45 Olfr22-ps1
  • chr11:73,954,692-73,955,625
Or1e1d-ps 45 Olfr396-ps1
  • chr11:73,928,007-73,928,942
Or1e20-ps 45 Olfr379-ps1
  • chr11:73,433,294-73,434,224
Or1e24-ps 45 Olfr383-ps1
  • chr11:73,540,422-73,541,353
Or1e27-ps 45 Olfr387-ps1
  • chr11:73,664,611-73,665,539
Or1e28-ps 45 Olfr388-ps1
  • chr11:73,724,085-73,725,022
Or1e31 45 Olfr391
  • chr11:73,798,820-73,799,755
Or1e36-ps 45 Olfr75-ps1
  • chr11:73,405,445-73,406,379
Rat
(Rattus norvegicus)
Mammalia Olr1468 29
  • 82.8 (n)
Oppossum
(Monodelphis domestica)
Mammalia OPOR52 30
  • 75 (a)
OneToMany
Species where no ortholog for OR1E1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1E1 Gene

ENSEMBL:
Gene Tree for OR1E1 (if available)
TreeFam:
Gene Tree for OR1E1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1E1: view image
Alliance of Genome Resources:
Additional Orthologs for OR1E1

Paralogs for OR1E1 Gene

(458) SIMAP similar genes for OR1E1 Gene using alignment to 1 proteins:

  • OR1E1_HUMAN

Pseudogenes.org Pseudogenes for OR1E1 Gene

genes like me logo Genes that share paralogs with OR1E1: view

Variants for OR1E1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1E1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs150989 -- p.Ala143Thr
rs1735011 -- p.Pro129Leu
rs379856 -- p.Ser262Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR1E1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR1E1 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv3892950 CNV loss 25118596
nsv1055740 CNV gain 25217958
nsv1059413 CNV loss 25217958
nsv1065489 CNV gain 25217958
nsv521277 CNV gain 19592680
nsv574232 CNV gain 21841781
nsv574236 CNV gain 21841781
nsv833341 CNV loss 17160897
nsv962248 CNV duplication 23825009

Variation tolerance for OR1E1 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1E1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1E1
Leiden Open Variation Database (LOVD)
OR1E1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1E1 Gene

Disorders for OR1E1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR1E1 Gene - From: COP

Disorder Aliases PubMed IDs
plasminogen deficiency, type i
  • dysplasminogenemia
pseudobulbar palsy
  • pseudobulbar paralysis
- elite association - COSMIC cancer census association via MalaCards
Search OR1E1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR1E1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OR1E1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR1E1 Gene

Publications for OR1E1 Gene

  1. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N … Lehrach H (Human molecular genetics 1994) 2 3 4
  2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4

Products for OR1E1 Gene

Sources for OR1E1 Gene