Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1D5 Gene

Aliases for OR1D5 Gene

  • Olfactory Receptor Family 1 Subfamily D Member 5 2 3 5
  • Olfactory Receptor 17-31 3 4
  • Olfactory Receptor 1D5 3 4
  • OR17-31 3 4
  • Olfactory Receptor, Family 1, Subfamily D, Member 5 2
  • Olfactory Receptor OR17-2 3
  • C17orf2 3
  • OR17-30 3
  • OR17-2 3
  • OR1D4 3

External Ids for OR1D5 Gene

Previous GeneCards Identifiers for OR1D5 Gene

  • GC17M003280
  • GC17U900018
  • GC17M003173
  • GC17M003174
  • GC17M002912
  • GC17M002965

Summaries for OR1D5 Gene

Entrez Gene Summary for OR1D5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1D5 Gene

OR1D5 (Olfactory Receptor Family 1 Subfamily D Member 5) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D2.

UniProtKB/Swiss-Prot Summary for OR1D5 Gene

Gene Wiki entry for OR1D5 Gene

Additional gene information for OR1D5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1D5 Gene

Genomics for OR1D5 Gene

GeneHancer (GH) Regulatory Elements for OR1D5 Gene

Promoters and enhancers for OR1D5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003065 Promoter 0.3 Ensembl 750.6 -1.6 -1594 0.4 OR1D5 piR-56133-081
GH17J003062 Enhancer 0.2 Ensembl 750.6 +1.2 1206 0.8 OR1D5 lnc-OR1D5-2
GH17J002389 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.6 +664.6 664595 18.6 ZNF785 SIN3A ZNF24 ZBTB40 SP1 CTCF ZBTB6 MLX SMARCE1 POLR2A MNT RF00457 PRPF8 SMYD4 METTL16 WDR81 HNRNPA1P16 SMG6 RN7SL608P ENSG00000263345
GH17J003885 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.6 -826.9 -826929 10.9 ZNF785 SIN3A SP1 ZBTB6 RBPJ POLR2A CTBP1 USF2 ZNF133 NFYC CAMKK1 ANKFY1 MYBBP1A PELP1 ENSG00000235085 ENSG00000262903 P2RX1 OR1E2 OR3A4P OR1E3
GH17J003534 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.6 -472.2 -472233 2.3 ZNF785 ZBTB40 ETV6 RAD21 HDGF ZBTB33 ZSCAN21 ZNF548 CREM MTA1 TRPV3 RN7SL608P ZZEF1 ANKFY1 OR1E2 OR3A4P OR1D3P OR1D5 OR1E3 OR1D2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1D5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR1D5 gene promoter:
  • AML1a
  • AP-1
  • AREB6
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for OR1D5 Gene

Genomic Locations for OR1D5 Gene
chr17:3,062,669-3,063,607
(GRCh38/hg38)
Size:
939 bases
Orientation:
Minus strand
chr17:2,965,963-2,966,901
(GRCh37/hg19)
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR1D5 Gene

Genes around OR1D5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1D5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1D5 Gene

Proteins for OR1D5 Gene

  • Protein details for OR1D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58170-OR1D5_HUMAN
    Recommended name:
    Olfactory receptor 1D5
    Protein Accession:
    P58170
    Secondary Accessions:
    • A0AUK4
    • Q96RA6

    Protein attributes for OR1D5 Gene

    Size:
    312 amino acids
    Molecular mass:
    35424 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1D5 Gene

Post-translational modifications for OR1D5 Gene

  • Glycosylation at Asn5

Other Protein References for OR1D5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1D5 Gene

Domains & Families for OR1D5 Gene

Gene Families for OR1D5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1D5 Gene

Suggested Antigen Peptide Sequences for OR1D5 Gene

GenScript: Design optimal peptide antigens:
  • OR1D5 protein (A0AUK4_HUMAN)
  • Olfactory receptor 17-31 (OR1D5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P58170

UniProtKB/Swiss-Prot:

OR1D5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1D5: view

Function for OR1D5 Gene

Molecular function for OR1D5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily D,member 5,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR1D5 Gene

Gene Ontology (GO) - Molecular Function for OR1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with OR1D5: view
genes like me logo Genes that share phenotypes with OR1D5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1D5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1D5 Gene

Localization for OR1D5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1D5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1D5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1D5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1D5 Gene

Pathways & Interactions for OR1D5 Gene

genes like me logo Genes that share pathways with OR1D5: view

Pathways by source for OR1D5 Gene

1 KEGG pathway for OR1D5 Gene

Interacting Proteins for OR1D5 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000459028 P58170-OR1D5_HUMAN for OR1D5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IBA 21873635
GO:0007608 sensory perception of smell TAS 1315913
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1D5: view

No data available for SIGNOR curated interactions for OR1D5 Gene

Drugs & Compounds for OR1D5 Gene

No Compound Related Data Available

Transcripts for OR1D5 Gene

mRNA/cDNA for OR1D5 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1D5

Alternative Splicing Database (ASD) splice patterns (SP) for OR1D5 Gene

No ASD Table

Relevant External Links for OR1D5 Gene

GeneLoc Exon Structure for
OR1D5
ECgene alternative splicing isoforms for
OR1D5

Expression for OR1D5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1D5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1D5 Gene:

OR1D5

SOURCE GeneReport for Unigene cluster for OR1D5 Gene:

Hs.553508
genes like me logo Genes that share expression patterns with OR1D5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1D5 Gene

Orthologs for OR1D5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1D5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468150 32
  • 98.72 (n)
OR1D5 33
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cOR1D8 32
  • 84.84 (n)
-- 33
  • 80 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OR1D5 32
  • 84.73 (n)
-- 33
  • 76 (a)
ManyToMany
-- 33
  • 75 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr412 33
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 47 (a)
ManyToMany
-- 33
  • 47 (a)
ManyToMany
-- 33
  • 47 (a)
ManyToMany
-- 33
  • 41 (a)
ManyToMany
Species where no ortholog for OR1D5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1D5 Gene

ENSEMBL:
Gene Tree for OR1D5 (if available)
TreeFam:
Gene Tree for OR1D5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1D5: view image

Paralogs for OR1D5 Gene

(451) SIMAP similar genes for OR1D5 Gene using alignment to 2 proteins:

  • OR1D5_HUMAN
  • A0AUK4_HUMAN

Pseudogenes.org Pseudogenes for OR1D5 Gene

genes like me logo Genes that share paralogs with OR1D5: view

Variants for OR1D5 Gene

Sequence variations from dbSNP and Humsavar for OR1D5 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001165709 -- 3,063,835(-) T/C upstream_transcript_variant
rs1001263129 -- 3,063,412(-) G/A coding_sequence_variant, missense_variant
rs1003105843 -- 3,064,040(-) A/G upstream_transcript_variant
rs1005005621 -- 3,064,557(-) C/T upstream_transcript_variant
rs1008933160 -- 3,062,424(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR1D5 Gene

Variant ID Type Subtype PubMed ID
dgv3084n100 CNV loss 25217958
esv2660206 CNV deletion 23128226
nsv1065489 CNV gain 25217958
nsv7288 OTHER inversion 18451855
nsv962245 CNV duplication 23825009

Variation tolerance for OR1D5 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.81; 89.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1D5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1D5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1D5 Gene

Disorders for OR1D5 Gene

Additional Disease Information for OR1D5

No disorders were found for OR1D5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1D5 Gene

Publications for OR1D5 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G … Lancet D (Genomics 2000) 2 3 4 56
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 56
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56

Products for OR1D5 Gene

Sources for OR1D5 Gene