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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR1D5 (Olfactory Receptor Family 1 Subfamily D Member 5) is a Protein Coding gene. Diseases associated with OR1D5 include Familial Hypocalciuric Hypercalcemia and Benign Paroxysmal Positional Nystagmus. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J003065 | Promoter | 0.3 | Ensembl | 600.7 | -1.6 | -1594 | 0.4 | OR1D5 piR-56133-081 OR1D2 | ||
GH17J003062 | Enhancer | 0.2 | Ensembl | 600.7 | +1.2 | 1206 | 0.8 | OR1D5 lnc-OR1D5-2 RAP1GAP2 | ||
GH17J003048 | Promoter/Enhancer | 1.5 | FANTOM5 ENCODE CraniofacialAtlas | 0.4 | +14.7 | 14652 | 1.3 | SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 FOS TARDBP DDX20 | RN7SL608P TSR1 METTL16 MNT ASPA PAFAH1B1 OR1D5 lnc-OR1D5-2 RAP1GAP2 | |
GH17J003001 | Enhancer | 1.3 | ENCODE CraniofacialAtlas dbSUPER | 0.2 | +59.8 | 59759 | 4.3 | SP1 HNRNPL CREB1 PRDM10 ZNF629 ZNF692 ZHX2 LARP7 PRDM1 ZIC2 | RAP1GAP2 RF00017-2230 RF00017-2229 OR1D5 | |
GH17J002975 | Promoter/Enhancer | 1.5 | ENCODE CraniofacialAtlas dbSUPER | 0.2 | +87.9 | 87909 | 1.3 | ZNF221 GATAD2A PRDM10 TFE3 SOX13 NFKBIZ ZNF692 RCOR2 FOXA1 GABPA | METTL16 ENSG00000262903 HNRNPA1P16 SMG6 RN7SL608P TSR1 RPL21P125 ENSG00000262692 HIC1 DPH1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | TAS,IEA | -- |
GO:0004984 | olfactory receptor activity | TAS,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007608 | sensory perception of smell | TAS | 1315913 |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC468150 30 |
|
||
OR1D5 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | cOR1D8 30 |
|
||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | OR1D5 30 |
|
||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Mouse (Mus musculus) |
Mammalia | Olfr412 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3084n100 | CNV | loss | 25217958 |
esv2660206 | CNV | deletion | 23128226 |
nsv1065489 | CNV | gain | 25217958 |
nsv7288 | OTHER | inversion | 18451855 |
nsv962245 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
familial hypocalciuric hypercalcemia |
|
|
benign paroxysmal positional nystagmus |
|
|