Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1D2 Gene

Aliases for OR1D2 Gene

  • Olfactory Receptor Family 1 Subfamily D Member 2 2 3 5
  • OR17-4 2 3 4
  • Olfactory Receptor-Like Protein HGMP07E 3 4
  • Olfactory Receptor OR17-6 3 4
  • Olfactory Receptor 17-4 3 4
  • Olfactory Receptor 1D2 3 4
  • OLFR1 3 4
  • Olfactory Receptor, Family 1, Subfamily D, Member 2 2
  • OR1D2 5

External Ids for OR1D2 Gene

Previous HGNC Symbols for OR1D2 Gene

  • OLFR1

Previous GeneCards Identifiers for OR1D2 Gene

  • GC17M003309
  • GC17M002946
  • GC17M003201
  • GC17M002942
  • GC17M002995
  • GC17M003092

Summaries for OR1D2 Gene

Entrez Gene Summary for OR1D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1D2 Gene

OR1D2 (Olfactory Receptor Family 1 Subfamily D Member 2) is a Protein Coding gene. Diseases associated with OR1D2 include Retinal Arteries, Tortuosity Of. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D5.

UniProtKB/Swiss-Prot Summary for OR1D2 Gene

  • Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.

Gene Wiki entry for OR1D2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1D2 Gene

Genomics for OR1D2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR1D2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003065 Promoter 0.3 Ensembl 0.3 +39.2 39221 0.4 OR1D5 piR-56133-081 OR1D2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1D2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1D2

Top Transcription factor binding sites by QIAGEN in the OR1D2 gene promoter:
  • AML1a
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GATA-2

Genomic Locations for OR1D2 Gene

Latest Assembly
chr17:3,088,484-3,104,422
(GRCh38/hg38)
Size:
15,939 bases
Orientation:
Minus strand

Previous Assembly
chr17:2,991,778-3,007,716
(GRCh37/hg19 by Entrez Gene)
Size:
15,939 bases
Orientation:
Minus strand

chr17:2,995,352-2,996,290
(GRCh37/hg19 by Ensembl)
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR1D2 Gene

Genes around OR1D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1D2 Gene

Proteins for OR1D2 Gene

  • Protein details for OR1D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34982-OR1D2_HUMAN
    Recommended name:
    Olfactory receptor 1D2
    Protein Accession:
    P34982
    Secondary Accessions:
    • Q6IFL8
    • Q96RA4
    • Q9UM78

    Protein attributes for OR1D2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1D2 Gene

Post-translational modifications for OR1D2 Gene

  • Glycosylation at Asn5 and Asn195
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1D2 Gene

Domains & Families for OR1D2 Gene

Gene Families for OR1D2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1D2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR1D2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor-like protein HGMP07E (OR1D2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P34982

UniProtKB/Swiss-Prot:

OR1D2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1D2: view

Function for OR1D2 Gene

Molecular function for OR1D2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.
GENATLAS Biochemistry:
olfactory receptor family 1,subfamily D,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR1D2 Gene

Gene Ontology (GO) - Molecular Function for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS,IEA --
GO:0004984 olfactory receptor activity IDA 12663925
GO:0042802 identical protein binding IPI 18840687
genes like me logo Genes that share ontologies with OR1D2: view
genes like me logo Genes that share phenotypes with OR1D2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1D2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1D2 Gene

Localization for OR1D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1D2 Gene

Cell membrane. Multi-pass membrane protein. Note=In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1D2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8097991
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1D2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1D2 Gene

Pathways & Interactions for OR1D2 Gene

genes like me logo Genes that share pathways with OR1D2: view

Pathways by source for OR1D2 Gene

1 KEGG pathway for OR1D2 Gene

Gene Ontology (GO) - Biological Process for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IDA 16820410
GO:0007338 single fertilization IEA --
GO:0007608 sensory perception of smell TAS 8097991
genes like me logo Genes that share ontologies with OR1D2: view

No data available for SIGNOR curated interactions for OR1D2 Gene

Drugs & Compounds for OR1D2 Gene

No Compound Related Data Available

Transcripts for OR1D2 Gene

mRNA/cDNA for OR1D2 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1D2

Alternative Splicing Database (ASD) splice patterns (SP) for OR1D2 Gene

No ASD Table

Relevant External Links for OR1D2 Gene

GeneLoc Exon Structure for
OR1D2

Expression for OR1D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR1D2 Gene

This gene is overexpressed in Testis (x28.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1D2

SOURCE GeneReport for Unigene cluster for OR1D2 Gene:

Hs.532771

mRNA Expression by UniProt/SwissProt for OR1D2 Gene:

P34982-OR1D2_HUMAN
Tissue specificity: Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium.
genes like me logo Genes that share expression patterns with OR1D2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1D2 Gene

Orthologs for OR1D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1D2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR1D2 29 30
  • 99.25 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC611352 29
  • 88.25 (n)
-- 30
  • 87 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or1d2 45 Olfr412 29 16
  • 85.47 (n)
Olfr54 30
  • 51 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Olr1520 29
  • 85.21 (n)
Cow
(Bos Taurus)
Mammalia -- 30
  • 82 (a)
ManyToMany
-- 30
  • 75 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 43 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 49 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 41 (a)
ManyToMany
Species where no ortholog for OR1D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR1D2 Gene

ENSEMBL:
Gene Tree for OR1D2 (if available)
TreeFam:
Gene Tree for OR1D2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR1D2: view image
Alliance of Genome Resources:
Additional Orthologs for OR1D2

Paralogs for OR1D2 Gene

(458) SIMAP similar genes for OR1D2 Gene using alignment to 1 proteins:

  • OR1D2_HUMAN

Pseudogenes.org Pseudogenes for OR1D2 Gene

genes like me logo Genes that share paralogs with OR1D2: view

Variants for OR1D2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1D2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs4300683 -- p.Thr240Ile
rs55803944 -- p.Val214Met
rs769423 -- p.Arg25Gln
rs9916628 -- p.Phe31Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR1D2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR1D2 Gene

Variant ID Type Subtype PubMed ID
dgv3084n100 CNV loss 25217958
dgv4n29 CNV loss 16826518
esv2660206 CNV deletion 23128226
nsv1065489 CNV gain 25217958
nsv7288 OTHER inversion 18451855
nsv978349 CNV duplication 23825009

Variation tolerance for OR1D2 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.41; 85.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1D2
Leiden Open Variation Database (LOVD)
OR1D2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1D2 Gene

Disorders for OR1D2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR1D2 Gene - From: COP

Disorder Aliases PubMed IDs
retinal arteries, tortuosity of
  • rator
- elite association - COSMIC cancer census association via MalaCards
Search OR1D2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR1D2

genes like me logo Genes that share disorders with OR1D2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR1D2 Gene

Publications for OR1D2 Gene

  1. The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism. (PMID: 8097991) Schurmans S … Parmentier M (Cytogenetics and cell genetics 1993) 3 4 22
  2. Large-scale production and study of a synthetic G protein-coupled receptor: human olfactory receptor 17-4. (PMID: 19581598) Cook BL … Zhang S (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22
  3. Efficient cell-free production of olfactory receptors: detergent optimization, structure, and ligand binding analyses. (PMID: 18840687) Kaiser L … Zhang S (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 22
  4. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PMID: 16820410) Neuhaus EM … Hatt H (Journal of cell science 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for OR1D2 Gene

Sources for OR1D2 Gene