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Aliases for OR1C1 Gene

Aliases for OR1C1 Gene

  • Olfactory Receptor Family 1 Subfamily C Member 1 2 3 5
  • Olfactory Receptor OR1-42 3 4
  • Olfactory Receptor TPCR27 3 4
  • Olfactory Receptor, Family 1, Subfamily C, Member 1 2
  • Olfactory Receptor 1C1 3
  • HSTPCR27 3
  • OR1.5.10 3
  • OR1-42 3
  • ORL211 3
  • TPCR27 3

External Ids for OR1C1 Gene

Previous GeneCards Identifiers for OR1C1 Gene

  • GC01M245778
  • GC01M243157
  • GC01M243968
  • GC01M244819
  • GC01M244820
  • GC01M244246
  • GC01M245987
  • GC01M247920

Summaries for OR1C1 Gene

Entrez Gene Summary for OR1C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1C1 Gene

OR1C1 (Olfactory Receptor Family 1 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot for OR1C1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1C1 Gene

Additional gene information for OR1C1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1C1 Gene

Genomics for OR1C1 Gene

GeneHancer (GH) Regulatory Elements for OR1C1 Gene

Promoters and enhancers for OR1C1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247294 Enhancer 0.9 ENCODE dbSUPER 4.9 +464.3 464278 3.7 MEIS2 PKNOX1 USF1 TEAD4 TAL1 SIN3A E4F1 ZNF316 POLR2A FOS ENSG00000202079 ZNF496 ZNF669 ENSG00000259865 OR1C1
GH01J247322 Enhancer 0.7 Ensembl ENCODE dbSUPER 4.6 +437.5 437483 1.6 BATF ZNF496 ENSG00000259865 OR1C1 ENSG00000202079
GH01J247741 Enhancer 0.4 ENCODE 0.4 +18.6 18614 1.3 GATA3 ZSCAN4 OR13G1 OR14A16 ENSG00000235749 OR14K1 OR1C1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1C1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR1C1 gene promoter:
  • CHOP-10
  • C/EBPalpha
  • ER-alpha
  • HNF-3beta
  • FOXO1
  • FOXO1a
  • Cart-1
  • Nkx6-1
  • c-Jun
  • c-Fos

Genomic Locations for OR1C1 Gene

Genomic Locations for OR1C1 Gene
5,711 bases
Minus strand
1,307 bases
Minus strand

Genomic View for OR1C1 Gene

Genes around OR1C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1C1 Gene

Proteins for OR1C1 Gene

  • Protein details for OR1C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1C1
    Protein Accession:
    Secondary Accessions:
    • B9EIR9
    • Q5VVD2
    • Q6IF97
    • Q8NGZ1
    • Q96R83

    Protein attributes for OR1C1 Gene

    314 amino acids
    Molecular mass:
    35042 Da
    Quaternary structure:
    No Data Available
    • Sequence=DAA04763.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR1C1 Gene

Post-translational modifications for OR1C1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR1C1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1C1 Gene

Domains & Families for OR1C1 Gene

Gene Families for OR1C1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1C1 Gene

Suggested Antigen Peptide Sequences for OR1C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1C1: view

Function for OR1C1 Gene

Molecular function for OR1C1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
genes like me logo Genes that share ontologies with OR1C1: view
genes like me logo Genes that share phenotypes with OR1C1: view

Animal Model Products

CRISPR Products

miRNA for OR1C1 Gene

miRTarBase miRNAs that target OR1C1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1C1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR1C1 Gene

Localization for OR1C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1C1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,NAS 9119360
genes like me logo Genes that share ontologies with OR1C1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1C1 Gene

Pathways & Interactions for OR1C1 Gene

genes like me logo Genes that share pathways with OR1C1: view

Pathways by source for OR1C1 Gene

1 KEGG pathway for OR1C1 Gene

Gene Ontology (GO) - Biological Process for OR1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1C1: view

No data available for SIGNOR curated interactions for OR1C1 Gene

Drugs & Compounds for OR1C1 Gene

No Compound Related Data Available

Transcripts for OR1C1 Gene

mRNA/cDNA for OR1C1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1C1 Gene

Olfactory receptor, family 1, subfamily C, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR1C1

Alternative Splicing Database (ASD) splice patterns (SP) for OR1C1 Gene

No ASD Table

Relevant External Links for OR1C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1C1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1C1 Gene

This gene is overexpressed in Testis (x45.7).

NURSA nuclear receptor signaling pathways regulating expression of OR1C1 Gene:


SOURCE GeneReport for Unigene cluster for OR1C1 Gene:

genes like me logo Genes that share expression patterns with OR1C1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1C1 Gene

Orthologs for OR1C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia OR08C09 33
  • 63.6 (n)
(Monodelphis domestica)
Mammalia OPOR44 34
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
(Mus musculus)
Mammalia Olfr1366 34
  • 51 (a)
(Bos Taurus)
Mammalia -- 34
  • 50 (a)
Species where no ortholog for OR1C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1C1 Gene

Gene Tree for OR1C1 (if available)
Gene Tree for OR1C1 (if available)
Evolutionary constrained regions (ECRs) for OR1C1: view image

Paralogs for OR1C1 Gene

Paralogs for OR1C1 Gene

(459) SIMAP similar genes for OR1C1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1C1: view

Variants for OR1C1 Gene

Sequence variations from dbSNP and Humsavar for OR1C1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000796558 -- 247,759,332(-) G/T upstream_transcript_variant
rs1001165001 -- 247,759,007(-) G/A/T upstream_transcript_variant
rs1002260751 -- 247,759,126(-) T/C upstream_transcript_variant
rs1002928347 -- 247,757,078(-) T/A downstream_transcript_variant
rs1006984713 -- 247,759,601(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR1C1 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
dgv900n54 CNV loss 21841781
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3589522 CNV gain 21293372
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549601 CNV loss 21841781
nsv999381 CNV loss 25217958

Variation tolerance for OR1C1 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1C1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1C1 Gene

Disorders for OR1C1 Gene

Additional Disease Information for OR1C1

No disorders were found for OR1C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1C1 Gene

Publications for OR1C1 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  5. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 44 58

Products for OR1C1 Gene

Sources for OR1C1 Gene

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