Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR1B1 Gene

Aliases for OR1B1 Gene

  • Olfactory Receptor Family 1 Subfamily B Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR9-26 3 4
  • Olfactory Receptor 1B1 3 4
  • Olfactory Receptor 9-B 3 4
  • OR9-B 3 4
  • Olfactory Receptor, Family 1, Subfamily B, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 1, Subfamily B, Member 1 3
  • OR9-26 3

External Ids for OR1B1 Gene

Previous GeneCards Identifiers for OR1B1 Gene

  • GC09U990121
  • GC09M120767
  • GC09M122471
  • GC09M124430
  • GC09M125390

Summaries for OR1B1 Gene

Entrez Gene Summary for OR1B1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR1B1 Gene

OR1B1 (Olfactory Receptor Family 1 Subfamily B Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1K1.

UniProtKB/Swiss-Prot Summary for OR1B1 Gene

Gene Wiki entry for OR1B1 Gene

Additional gene information for OR1B1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR1B1 Gene

Genomics for OR1B1 Gene

GeneHancer (GH) Regulatory Elements for OR1B1 Gene

Promoters and enhancers for OR1B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J122355 Enhancer 0.7 FANTOM5 Ensembl 18.7 +274.1 274072 3 CTCF RAD21 ZNF143 ZNF652 IKZF1 ZNF444 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 ENSG00000233616
GH09J122580 Enhancer 1 Ensembl ENCODE 10.9 +49.0 48972 1.2 TCF12 JUND EP300 JUN TAF9B NCOR1 NFRKB ZNF316 NFIC TRIM24 OR1N2 OR1B1 OR1N1 OR1J4 OR1J2 OR1K1 OR1H1P OR1J1 OR1Q1 OR1L8
GH09J122766 Enhancer 0.2 FANTOM5 5.7 -137.4 -137432 0.4 OR1J4 OR1N2 OR1L8 OR1K1 OR5C1 OR1Q1 OR1J2 OR1L1 OR1B1 OR1L4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1B1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR1B1

Top Transcription factor binding sites by QIAGEN in the OR1B1 gene promoter:
  • ATF6
  • CUTL1
  • GATA-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • NRSF form 1
  • NRSF form 2

Genomic Locations for OR1B1 Gene

Genomic Locations for OR1B1 Gene
chr9:122,628,579-122,629,573
(GRCh38/hg38)
Size:
995 bases
Orientation:
Minus strand
chr9:125,390,858-125,391,852
(GRCh37/hg19)
Size:
995 bases
Orientation:
Minus strand

Genomic View for OR1B1 Gene

Genes around OR1B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1B1 Gene

Proteins for OR1B1 Gene

  • Protein details for OR1B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGR6-OR1B1_HUMAN
    Recommended name:
    Olfactory receptor 1B1
    Protein Accession:
    Q8NGR6
    Secondary Accessions:
    • Q6IFN3

    Protein attributes for OR1B1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35293 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04627.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR1B1 Gene

Post-translational modifications for OR1B1 Gene

  • Glycosylation at Asn7 and Asn23
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1B1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1B1 Gene

Domains & Families for OR1B1 Gene

Gene Families for OR1B1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1B1 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR1B1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR9-26 (OR1B1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGR6

UniProtKB/Swiss-Prot:

OR1B1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1B1: view

Function for OR1B1 Gene

Molecular function for OR1B1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor, family1,subfamily B,member 1,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR1B1: view
genes like me logo Genes that share phenotypes with OR1B1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1B1 Gene

Localization for OR1B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1B1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1B1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1B1 Gene

Pathways & Interactions for OR1B1 Gene

genes like me logo Genes that share pathways with OR1B1: view

Pathways by source for OR1B1 Gene

Interacting Proteins for OR1B1 Gene

;

Gene Ontology (GO) - Biological Process for OR1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1B1: view

No data available for SIGNOR curated interactions for OR1B1 Gene

Drugs & Compounds for OR1B1 Gene

No Compound Related Data Available

Transcripts for OR1B1 Gene

mRNA/cDNA for OR1B1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1B1 Gene

No ASD Table

Relevant External Links for OR1B1 Gene

GeneLoc Exon Structure for
OR1B1

Expression for OR1B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1B1 Gene

Protein differential expression in normal tissues from HIPED for OR1B1 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR1B1 Gene



Protein tissue co-expression partners for OR1B1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR1B1

SOURCE GeneReport for Unigene cluster for OR1B1 Gene:

Hs.553710
genes like me logo Genes that share expression patterns with OR1B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1B1 Gene

Orthologs for OR1B1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1B1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Or1b1 47 Olfr362 17 30
  • 84.6 (n)
cow
(Bos Taurus)
Mammalia OR1B1 30
  • 83.92 (n)
rat
(Rattus norvegicus)
Mammalia Olr425 30
  • 83.23 (n)
Species where no ortholog for OR1B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1B1 Gene

ENSEMBL:
Gene Tree for OR1B1 (if available)
TreeFam:
Gene Tree for OR1B1 (if available)

Paralogs for OR1B1 Gene

(445) SIMAP similar genes for OR1B1 Gene using alignment to 1 proteins:

  • OR1B1_HUMAN
genes like me logo Genes that share paralogs with OR1B1: view

Variants for OR1B1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR1B1 Gene

OR1B1_HUMAN-Q8NGR6
A stop codon at position Arg-192 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR1B1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs11421222 Benign: not specified 122,629,491(-) C/CA FRAMESHIFT_VARIANT
rs1476858 - p.Cys263Trp
rs1476859 - p.Ala230Thr
rs1536929 - p.Leu149Ser
rs1556189 - p.Val314Gly

Additional dbSNP identifiers (rs#s) for OR1B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR1B1 Gene

Variant ID Type Subtype PubMed ID
nsv1039785 CNV gain 25217958
nsv1054800 CNV loss 25217958
nsv6705 CNV insertion 18451855

Variation tolerance for OR1B1 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.05; 98.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1B1 Gene

Human Gene Mutation Database (HGMD)
OR1B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1B1

SNP Genotyping and Copy Number Assay Products

Disorders for OR1B1 Gene

Additional Disease Information for OR1B1

No disorders were found for OR1B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1B1 Gene

Publications for OR1B1 Gene

  1. Common null variant, Arg192Stop, in a G-protein coupled receptor, olfactory receptor 1B1, associated with decreased serum cholinesterase activity. (PMID: 18328065) Koyano S … Kawata S (Hepatology research : the official journal of the Japan Society of Hepatology 2008) 3 23 54
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 54
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  4. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for OR1B1 Gene

Sources for OR1B1 Gene