Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR1A2 Gene

Aliases for OR1A2 Gene

  • Olfactory Receptor Family 1 Subfamily A Member 2 2 3 5
  • Olfactory Receptor OR17-10 3 4
  • Olfactory Receptor 17-6 3 4
  • OR17-6 3 4
  • Olfactory Receptor, Family 1, Subfamily A, Member 2 2
  • Olfactory Receptor 1A2 3

External Ids for OR1A2 Gene

Previous GeneCards Identifiers for OR1A2 Gene

  • GC17P003415
  • GC17P003051
  • GC17P003307
  • GC17P003047
  • GC17P003100

Summaries for OR1A2 Gene

Entrez Gene Summary for OR1A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1A2 Gene

OR1A2 (Olfactory Receptor Family 1 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1A1.

UniProtKB/Swiss-Prot for OR1A2 Gene

  • Odorant receptor.

Gene Wiki entry for OR1A2 Gene

Additional gene information for OR1A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1A2 Gene

Genomics for OR1A2 Gene

GeneHancer (GH) Regulatory Elements for OR1A2 Gene

Promoters and enhancers for OR1A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003167 Enhancer 0.7 Ensembl ENCODE 11.4 -29.7 -29719 0.8 IKZF1 IKZF2 PRDM1 IRF4 SPI1 OR1A2 OR1E2 ENSG00000261848 OR1P1 GC17P003146
GH17J003631 Enhancer 0.2 FANTOM5 13.6 +434.0 434013 0 OR1E2 OR1A2 SHPK OR1A1 OR3A2 OR1E1 ENSG00000262304 LOC100422717
GH17J003130 Enhancer 0.2 FANTOM5 9.1 -66.7 -66688 0.2 OR3A2 OR1A1 OR1E2 OR1G1 OR1A2 TRPV3 TRPV1 GC17P003146
GH17J003550 Enhancer 0.4 FANTOM5 4 +352.8 352750 0.3 ZNF366 ZBTB17 TRPV3 OR1G1 OR1A1 OR1A2 OR1E2 GC17M003518
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR1A2 gene promoter:
  • MRF-2
  • C/EBPalpha
  • SEF-1 (1)
  • GATA-3
  • HEN1
  • LyF-1
  • FOXJ2 (long isoform)
  • FOXJ2
  • LHX3b
  • Lhx3a

Genomic Locations for OR1A2 Gene

Genomic Locations for OR1A2 Gene
932 bases
Plus strand
930 bases
Plus strand

Genomic View for OR1A2 Gene

Genes around OR1A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1A2 Gene

Proteins for OR1A2 Gene

  • Protein details for OR1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1A2
    Protein Accession:
    Secondary Accessions:
    • Q3KPH3
    • Q6IFM0
    • Q6NTD8
    • Q96R86

    Protein attributes for OR1A2 Gene

    309 amino acids
    Molecular mass:
    34396 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1A2 Gene

Post-translational modifications for OR1A2 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1A2 Gene

Domains & Families for OR1A2 Gene

Gene Families for OR1A2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1A2 Gene

Suggested Antigen Peptide Sequences for OR1A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1A2: view

Function for OR1A2 Gene

Molecular function for OR1A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily A,member 2,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1A2: view
genes like me logo Genes that share phenotypes with OR1A2: view

Animal Model Products

miRNA for OR1A2 Gene

miRTarBase miRNAs that target OR1A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR1A2 Gene

Localization for OR1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1A2 Gene

Pathways & Interactions for OR1A2 Gene

genes like me logo Genes that share pathways with OR1A2: view

Pathways by source for OR1A2 Gene

1 KEGG pathway for OR1A2 Gene

Gene Ontology (GO) - Biological Process for OR1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR1A2: view

No data available for SIGNOR curated interactions for OR1A2 Gene

Drugs & Compounds for OR1A2 Gene

No Compound Related Data Available

Transcripts for OR1A2 Gene

mRNA/cDNA for OR1A2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1A2 Gene

Olfactory receptor, family 1, subfamily A, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1A2 Gene

No ASD Table

Relevant External Links for OR1A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1A2 Gene:


SOURCE GeneReport for Unigene cluster for OR1A2 Gene:

genes like me logo Genes that share expression patterns with OR1A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1A2 Gene

Orthologs for OR1A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 34
  • 80 (a)
(Canis familiaris)
Mammalia OR1A2 34
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
-- 34
  • 44 (a)
-- 34
  • 43 (a)
-- 34
  • 40 (a)
Species where no ortholog for OR1A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1A2 Gene

Gene Tree for OR1A2 (if available)
Gene Tree for OR1A2 (if available)
Evolutionary constrained regions (ECRs) for OR1A2: view image

Paralogs for OR1A2 Gene

Paralogs for OR1A2 Gene

(453) SIMAP similar genes for OR1A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1A2: view

Variants for OR1A2 Gene

Sequence variations from dbSNP and Humsavar for OR1A2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000481817 -- 3,197,286(+) C/A upstream_transcript_variant
rs1001140574 -- 3,198,776(+) A/G downstream_transcript_variant
rs1001805176 -- 3,196,259(+) T/A/G upstream_transcript_variant
rs1003629333 -- 3,196,466(+) T/C upstream_transcript_variant
rs1005762278 -- 3,196,755(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR1A2 Gene

Variant ID Type Subtype PubMed ID
dgv3084n100 CNV loss 25217958
dgv4n29 CNV loss 16826518
esv2660206 CNV deletion 23128226
esv3639739 CNV loss 21293372
esv3639740 CNV loss 21293372
esv3892949 CNV loss 25118596
esv3892950 CNV loss 25118596
nsv1060926 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv457637 CNV loss 19166990
nsv526486 CNV gain 19592680
nsv574230 CNV loss 21841781
nsv7288 OTHER inversion 18451855

Variation tolerance for OR1A2 Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.67; 97.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1A2 Gene

Disorders for OR1A2 Gene

Additional Disease Information for OR1A2

No disorders were found for OR1A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1A2 Gene

Publications for OR1A2 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G … Lancet D (Genomics 2000) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  5. Genome-wide association study of the five-factor model of personality in young Korean women. (PMID: 23903073) Kim HN … Kim HL (Journal of human genetics 2013) 3 58

Products for OR1A2 Gene

Sources for OR1A2 Gene

Loading form....