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Aliases for OR1A1 Gene

Aliases for OR1A1 Gene

  • Olfactory Receptor Family 1 Subfamily A Member 1 2 3 5
  • Olfactory Receptor OR17-11 3 4
  • Olfactory Receptor 17-7 3 4
  • OR17-7 3 4
  • Olfactory Receptor, Family 1, Subfamily A, Member 1 2
  • Olfactory Receptor 1A1 3

External Ids for OR1A1 Gene

Previous GeneCards Identifiers for OR1A1 Gene

  • GC17P003433
  • GC17P003069
  • GC17P003325
  • GC17P003065
  • GC17P003118

Summaries for OR1A1 Gene

Entrez Gene Summary for OR1A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1A1 Gene

OR1A1 (Olfactory Receptor Family 1 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1A2.

UniProtKB/Swiss-Prot for OR1A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1A1 Gene

Additional gene information for OR1A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1A1 Gene

Genomics for OR1A1 Gene

GeneHancer (GH) Regulatory Elements for OR1A1 Gene

Promoters and enhancers for OR1A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003130 Enhancer 0.2 FANTOM5 14 -76.7 -76710 0.2 OR3A2 OR1A1 OR1E2 OR1G1 OR1A2 TRPV3 TRPV1 GC17P003146
GH17J003550 Enhancer 0.4 FANTOM5 5.8 +342.7 342728 0.3 ZNF366 ZBTB17 TRPV3 OR1G1 OR1A1 OR1A2 OR1E2 GC17M003518
GH17J003631 Enhancer 0.2 FANTOM5 7 +424.0 423991 0 OR1E2 OR1A2 SHPK OR1A1 OR3A2 OR1E1 ENSG00000262304 LOC100422717
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR1A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR1A1 gene promoter:
  • MRF-2
  • PPAR-gamma2
  • PPAR-gamma1
  • C/EBPalpha
  • AP-4
  • SEF-1 (1)
  • LUN-1
  • GATA-3

Genomic Locations for OR1A1 Gene

Genomic Locations for OR1A1 Gene
11,358 bases
Plus strand
930 bases
Plus strand

Genomic View for OR1A1 Gene

Genes around OR1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1A1 Gene

Proteins for OR1A1 Gene

  • Protein details for OR1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1A1
    Protein Accession:
    Secondary Accessions:
    • A5D914
    • Q6IFM1
    • Q6NTA9
    • Q96R87

    Protein attributes for OR1A1 Gene

    309 amino acids
    Molecular mass:
    34565 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1A1 Gene

Post-translational modifications for OR1A1 Gene

  • Glycosylation at isoforms=264 and Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1A1 Gene

Domains & Families for OR1A1 Gene

Gene Families for OR1A1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1A1 Gene

Suggested Antigen Peptide Sequences for OR1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1A1: view

Function for OR1A1 Gene

Molecular function for OR1A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily A,member 1,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1A1: view
genes like me logo Genes that share phenotypes with OR1A1: view

Animal Model Products

miRNA for OR1A1 Gene

miRTarBase miRNAs that target OR1A1

Clone Products

  • Addgene plasmids for OR1A1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR1A1 Gene

Localization for OR1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1A1 Gene

Pathways & Interactions for OR1A1 Gene

genes like me logo Genes that share pathways with OR1A1: view

Pathways by source for OR1A1 Gene

1 KEGG pathway for OR1A1 Gene

Gene Ontology (GO) - Biological Process for OR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1A1: view

No data available for SIGNOR curated interactions for OR1A1 Gene

Drugs & Compounds for OR1A1 Gene

No Compound Related Data Available

Transcripts for OR1A1 Gene

mRNA/cDNA for OR1A1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1A1 Gene

Olfactory receptor, family 1, subfamily A, member 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for OR1A1

Alternative Splicing Database (ASD) splice patterns (SP) for OR1A1 Gene

No ASD Table

Relevant External Links for OR1A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1A1 Gene

Protein differential expression in normal tissues from HIPED for OR1A1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR1A1 Gene

Protein tissue co-expression partners for OR1A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1A1 Gene:


SOURCE GeneReport for Unigene cluster for OR1A1 Gene:

genes like me logo Genes that share expression patterns with OR1A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1A1 Gene

Orthologs for OR1A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR1A1 34 33
  • 99.24 (n)
(Bos Taurus)
Mammalia LOC540082 33
  • 88.24 (n)
-- 34
  • 88 (a)
-- 34
  • 85 (a)
(Canis familiaris)
Mammalia COR1A3 33
  • 87.66 (n)
-- 34
  • 50 (a)
(Mus musculus)
Mammalia Or1a1b 51 Olfr43 16 34
  • 83 (a)
Or1a1 51 Olfr403 34 33
  • 82.42 (n)
Or1a5-ps 51 Olfr405-ps1
  • chr11:74,255,699-74,256,631
Or1a6-ps 51 Olfr408-ps1
  • chr11:74,298,136-74,299,073
Or1a7-ps 51 Olfr407-ps1
  • chr11:74,280,718-74,281,732
(Rattus norvegicus)
Mammalia Olr1514 33
  • 82.57 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
-- 34
  • 46 (a)
-- 34
  • 45 (a)
-- 34
  • 43 (a)
Species where no ortholog for OR1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1A1 Gene

Gene Tree for OR1A1 (if available)
Gene Tree for OR1A1 (if available)
Evolutionary constrained regions (ECRs) for OR1A1: view image

Paralogs for OR1A1 Gene

Paralogs for OR1A1 Gene

(457) SIMAP similar genes for OR1A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1A1: view

Variants for OR1A1 Gene

Sequence variations from dbSNP and Humsavar for OR1A1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000983798 -- 3,214,865(+) A/G upstream_transcript_variant
rs1003200926 -- 3,216,400(+) C/A coding_sequence_variant, synonymous_variant
rs1003574664 -- 3,214,301(+) C/T upstream_transcript_variant
rs1003648354 -- 3,214,491(+) C/G upstream_transcript_variant
rs1003877885 -- 3,214,012(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR1A1 Gene

Variant ID Type Subtype PubMed ID
dgv4n29 CNV loss 16826518
esv2660206 CNV deletion 23128226
esv3639739 CNV loss 21293372
esv3639740 CNV loss 21293372
esv3892949 CNV loss 25118596
esv3892950 CNV loss 25118596
nsv1060926 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv457637 CNV loss 19166990
nsv526486 CNV gain 19592680
nsv574230 CNV loss 21841781
nsv574231 CNV gain 21841781
nsv7288 OTHER inversion 18451855

Variation tolerance for OR1A1 Gene

Residual Variation Intolerance Score: 90.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.35; 95.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1A1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1A1 Gene

Disorders for OR1A1 Gene

Additional Disease Information for OR1A1

No disorders were found for OR1A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1A1 Gene

Publications for OR1A1 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G … Lancet D (Genomics 2000) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  4. Activation of OR1A1 suppresses PPAR-γ expression by inducing HES-1 in cultured hepatocytes. (PMID: 25817041) Wu C … Lee SJ (The international journal of biochemistry & cell biology 2015) 3 58
  5. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. (PMID: 17601748) Schmiedeberg K … Krautwurst D (Journal of structural biology 2007) 3 58

Products for OR1A1 Gene

Sources for OR1A1 Gene

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