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Aliases for OR14K1 Gene

Aliases for OR14K1 Gene

  • Olfactory Receptor Family 14 Subfamily K Member 1 2 3 5
  • Olfactory Receptor, Family 5, Subfamily AY, Member 1 2 3
  • Olfactory Receptor OR1-39 3 4
  • Olfactory Receptor 5AY1 3 4
  • OR5AY1 3 4
  • Olfactory Receptor, Family 14, Subfamily K, Member 1 2
  • Olfactory Receptor 14K1 3
  • OR1.5.9 3
  • OR1-39 3

External Ids for OR14K1 Gene

Previous HGNC Symbols for OR14K1 Gene

  • OR5AY1

Previous GeneCards Identifiers for OR14K1 Gene

  • GC01P245969
  • GC01P247901

Summaries for OR14K1 Gene

Entrez Gene Summary for OR14K1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR14K1 Gene

OR14K1 (Olfactory Receptor Family 14 Subfamily K Member 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR14A16.

UniProtKB/Swiss-Prot for OR14K1 Gene

  • Odorant receptor.

Gene Wiki entry for OR14K1 Gene

Additional gene information for OR14K1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR14K1 Gene

Genomics for OR14K1 Gene

GeneHancer (GH) Regulatory Elements for OR14K1 Gene

Promoters and enhancers for OR14K1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247741 Enhancer 0.4 ENCODE 0.7 +3.3 3327 1.3 GATA3 ZSCAN4 OR13G1 OR14A16 ENSG00000235749 OR14K1 OR1C1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR14K1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR14K1 Gene

Genomic Locations for OR14K1 Gene
945 bases
Plus strand
945 bases
Plus strand

Genomic View for OR14K1 Gene

Genes around OR14K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR14K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR14K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR14K1 Gene

Proteins for OR14K1 Gene

  • Protein details for OR14K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 14K1
    Protein Accession:
    Secondary Accessions:
    • A8MPV5
    • Q6IF85
    • Q96R53

    Protein attributes for OR14K1 Gene

    314 amino acids
    Molecular mass:
    34861 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05850.1; Type=Frameshift; Positions=314; Evidence={ECO:0000305}; Sequence=DAA04775.1; Type=Frameshift; Positions=314; Evidence={ECO:0000305};

neXtProt entry for OR14K1 Gene

Post-translational modifications for OR14K1 Gene

Other Protein References for OR14K1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR14K1 Gene

Domains & Families for OR14K1 Gene

Gene Families for OR14K1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR14K1 Gene

Suggested Antigen Peptide Sequences for OR14K1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR14K1: view

Function for OR14K1 Gene

Molecular function for OR14K1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR14K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR14K1: view
genes like me logo Genes that share phenotypes with OR14K1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR14K1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR14K1 Gene

Localization for OR14K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR14K1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR14K1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR14K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR14K1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR14K1 Gene

Pathways & Interactions for OR14K1 Gene

SuperPathways for OR14K1 Gene

No Data Available

Interacting Proteins for OR14K1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000283225 for OR14K1 Gene via STRING

Gene Ontology (GO) - Biological Process for OR14K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR14K1: view

No data available for Pathways by source and SIGNOR curated interactions for OR14K1 Gene

Drugs & Compounds for OR14K1 Gene

No Compound Related Data Available

Transcripts for OR14K1 Gene

mRNA/cDNA for OR14K1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR14K1

Alternative Splicing Database (ASD) splice patterns (SP) for OR14K1 Gene

No ASD Table

Relevant External Links for OR14K1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR14K1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR14K1 Gene

mRNA differential expression in normal tissues according to GTEx for OR14K1 Gene

This gene is overexpressed in Testis (x19.6).

NURSA nuclear receptor signaling pathways regulating expression of OR14K1 Gene:

genes like me logo Genes that share expression patterns with OR14K1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR14K1 Gene

Orthologs for OR14K1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR14K1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR14K1 34
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
-- 34
  • 55 (a)
-- 34
  • 53 (a)
-- 34
  • 53 (a)
-- 34
  • 52 (a)
-- 34
  • 52 (a)
-- 34
  • 51 (a)
-- 34
  • 51 (a)
-- 34
  • 50 (a)
-- 34
  • 50 (a)
-- 34
  • 50 (a)
-- 34
  • 49 (a)
-- 34
  • 48 (a)
-- 34
  • 44 (a)
(Mus musculus)
Mammalia Olfr128 34
  • 47 (a)
Species where no ortholog for OR14K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR14K1 Gene

Gene Tree for OR14K1 (if available)
Gene Tree for OR14K1 (if available)
Evolutionary constrained regions (ECRs) for OR14K1: view image

Paralogs for OR14K1 Gene

Paralogs for OR14K1 Gene

(424) SIMAP similar genes for OR14K1 Gene using alignment to 1 proteins:

  • O14K1_HUMAN
genes like me logo Genes that share paralogs with OR14K1: view

Variants for OR14K1 Gene

Variation tolerance for OR14K1 Gene

Gene Damage Index Score: 3.56; 55.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR14K1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for OR14K1 Gene

Disorders for OR14K1 Gene

No disorders were found for OR14K1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for OR14K1 Gene

Publications for OR14K1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  5. The complete human olfactory subgenome. (PMID: 11337468) Glusman G … Lancet D (Genome research 2001) 3 58

Products for OR14K1 Gene

Sources for OR14K1 Gene

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