Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR14J1 Gene

Aliases for OR14J1 Gene

  • Olfactory Receptor Family 14 Subfamily J Member 1 2 3 5
  • Hs6M1-28 2 3 4
  • Olfactory Receptor OR6-25 3 4
  • Olfactory Receptor 14J1 3 4
  • Olfactory Receptor 5U1 3 4
  • OR5U1 3 4
  • Olfactory Receptor, Family 14, Subfamily J, Member 1 2
  • Olfactory Receptor, Family 5, Subfamily U, Member 1 2
  • Olfactory Receptor, Family 5, Subfamily U Member 1 3
  • BA150A6.4 3
  • OR6-25 3
  • OR14J1 5

External Ids for OR14J1 Gene

Previous HGNC Symbols for OR14J1 Gene

  • OR5U1

Previous GeneCards Identifiers for OR14J1 Gene

  • GC06P029384
  • GC06P029274
  • GC06Po29204

Summaries for OR14J1 Gene

Entrez Gene Summary for OR14J1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR14J1 Gene

OR14J1 (Olfactory Receptor Family 14 Subfamily J Member 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR14A16.

UniProtKB/Swiss-Prot Summary for OR14J1 Gene

Gene Wiki entry for OR14J1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR14J1 Gene

Genomics for OR14J1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR14J1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J028814 Enhancer 0.8 FANTOM5 4.7 -487.3 -487323 0.1 IKZF1 ZNF600 ZNF580 ETS1 ZNF639 KLF7 ZNF610 SP2 GABPB1 ZNF843 HSALNG0049006-002 ZNF311 ZKSCAN3 ZFP57 ZBED9 ZNF602P OR14J1 GPX6 OR2W1 OR2J3
GH06J029467 Enhancer 0.2 FANTOM5 11.2 +166.0 165998 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
GH06J029226 Enhancer 0.2 Ensembl 10.1 -75.4 -75400 0.6 TRIM27 OR2W1 OR14J1 MICD HSALNG0049046 LOC101929006 OR2J2
GH06J028854 Enhancer 0.5 FANTOM5 1.5 -446.8 -446817 0.2 FOXA2 HDAC2 ZMYM3 KDM1A HCG14 TRIM27 HCG15 ENSG00000244349 ZNF602P OR2J3 OR2B3 OR14J1 RPL13P piR-55194-322
GH06J029477 Enhancer 0.2 FANTOM5 1.7 +176.4 176397 0.6 HSALNG0049060-001 lnc-MAS1L-1 MAS1L OR12D3 OR5V1 UBD LINC01015 OR2H2 OR14J1 MAS1LP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR14J1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR14J1

Top Transcription factor binding sites by QIAGEN in the OR14J1 gene promoter:
  • C/EBPalpha
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NF-1
  • NF-1/L
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for OR14J1 Gene

Latest Assembly
chr6:29,301,701-29,313,017
(GRCh38/hg38)
Size:
11,317 bases
Orientation:
Plus strand

Previous Assembly
chr6:29,269,478-29,280,794
(GRCh37/hg19 by Entrez Gene)
Size:
11,317 bases
Orientation:
Plus strand

chr6:29,274,403-29,275,519
(GRCh37/hg19 by Ensembl)
Size:
1,117 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr6(ALT_REF_LOCI_1):567,357-578,684 (+)
  • chr6(ALT_REF_LOCI_2):788,291-799,608 (+)
  • chr6(ALT_REF_LOCI_3):567,334-578,661 (+)
  • chr6(ALT_REF_LOCI_4):567,297-578,620 (+)
  • chr6(ALT_REF_LOCI_5):567,473-578,841 (+)
  • chr6(ALT_REF_LOCI_7):611,124-622,451 (+)

Genomic View for OR14J1 Gene

Genes around OR14J1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR14J1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR14J1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR14J1 Gene

  • Protein details for OR14J1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGF5-O14J1_HUMAN
    Recommended name:
    Olfactory receptor 14J1
    Protein Accession:
    Q9UGF5
    Secondary Accessions:
    • A2BEC2
    • B0V078
    • Q5ST27

    Protein attributes for OR14J1 Gene

    Size:
    321 amino acids
    Molecular mass:
    35892 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR14J1 Gene

Post-translational modifications for OR14J1 Gene

  • Glycosylation at Asn3

Other Protein References for OR14J1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR14J1 Gene

Domains & Families for OR14J1 Gene

Gene Families for OR14J1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR14J1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR14J1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR6-25 (O14J1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UGF5

UniProtKB/Swiss-Prot:

O14J1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR14J1: view

Function for OR14J1 Gene

Molecular function for OR14J1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR14J1 Gene

Gene Ontology (GO) - Molecular Function for OR14J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR14J1: view
genes like me logo Genes that share phenotypes with OR14J1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR14J1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR14J1 Gene

Localization for OR14J1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR14J1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR14J1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for OR14J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR14J1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR14J1 Gene

Pathways & Interactions for OR14J1 Gene

genes like me logo Genes that share pathways with OR14J1: view

Pathways by source for OR14J1 Gene

1 BioSystems pathway for OR14J1 Gene
1 KEGG pathway for OR14J1 Gene

Interacting Proteins for OR14J1 Gene

Gene Ontology (GO) - Biological Process for OR14J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR14J1: view

No data available for SIGNOR curated interactions for OR14J1 Gene

Drugs & Compounds for OR14J1 Gene

No Compound Related Data Available

Transcripts for OR14J1 Gene

mRNA/cDNA for OR14J1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR14J1

Alternative Splicing Database (ASD) splice patterns (SP) for OR14J1 Gene

No ASD Table

Relevant External Links for OR14J1 Gene

GeneLoc Exon Structure for
OR14J1

Expression for OR14J1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR14J1 Gene

mRNA differential expression in normal tissues according to GTEx for OR14J1 Gene

This gene is overexpressed in Testis (x46.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR14J1

SOURCE GeneReport for Unigene cluster for OR14J1 Gene:

Hs.632004
genes like me logo Genes that share expression patterns with OR14J1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR14J1 Gene

Orthologs for OR14J1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR14J1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC471935 29
  • 99.38 (n)
OR14J1 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC510530 29
  • 88.68 (n)
OR14J1 30
  • 67 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100856296 29
  • 85.83 (n)
-- 30
  • 83 (a)
OneToMany
-- 30
  • 83 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or14j1 45 Olfr125 29 16 30
  • 81.77 (n)
OneToOne
Or14j10 45 Olfr116
  • chr17:37,623,671-37,624,633
Or14j2 45 Olfr113
  • chr17:37,574,486-37,575,496
Or14j3 45 Olfr114
  • chr17:37,589,416-37,590,351
Or14j4 45 Olfr115
  • chr17:37,609,820-37,610,830
Or14j5 45 Olfr126
  • chr17:37,850,594-37,851,550
Or14j6 45 Olfr127
  • chr17:37,903,548-37,904,516
Or14j7 45 Olfr128
  • chr17:37,923,457-37,924,491
Or14j8 45 Olfr761
  • chr17:37,952,054-37,953,022
Or14j9 45 Olfr112
  • chr17:37,563,350-37,564,384
Or14q1-ps 45 Olfr756-ps1
  • chr17:37,285,147-37,286,045
Rat
(Rattus norvegicus)
Mammalia Olr1693 29
  • 80.94 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 57 (a)
OneToMany
-- 30
  • 47 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 55 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves LOC101747306 29
  • 62.35 (n)
Species where no ortholog for OR14J1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR14J1 Gene

ENSEMBL:
Gene Tree for OR14J1 (if available)
TreeFam:
Gene Tree for OR14J1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR14J1: view image
Alliance of Genome Resources:
Additional Orthologs for OR14J1

Paralogs for OR14J1 Gene

(439) SIMAP similar genes for OR14J1 Gene using alignment to 1 proteins:

  • O14J1_HUMAN
genes like me logo Genes that share paralogs with OR14J1: view

Variants for OR14J1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR14J1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs17404424 -- p.Val278Met
rs9257694 -- p.Met7Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR14J1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR14J1 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
esv3608473 CNV gain 21293372
nsv1015796 CNV gain 25217958
nsv1020683 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv830624 CNV loss 17160897

Variation tolerance for OR14J1 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR14J1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR14J1
Leiden Open Variation Database (LOVD)
OR14J1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR14J1 Gene

Disorders for OR14J1 Gene

Additional Disease Information for OR14J1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR14J1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR14J1 Gene

Publications for OR14J1 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 40
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR14J1 Gene

Sources for OR14J1 Gene