Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR14I1 Gene

Aliases for OR14I1 Gene

  • Olfactory Receptor Family 14 Subfamily I Member 1 2 3 5
  • Olfactory Receptor 14I1 3 4
  • Olfactory Receptor 5BU1 3 4
  • OR5BU1P 3 4
  • OR5BU1 3 4
  • Olfactory Receptor, Family 5, Subfamily BU, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 5, Subfamily BU, Member 1 2
  • Olfactory Receptor, Family 14, Subfamily I, Member 1 2
  • OR14I1 5

External Ids for OR14I1 Gene

Previous HGNC Symbols for OR14I1 Gene

  • OR5BU1P
  • OR5BU1

Previous GeneCards Identifiers for OR14I1 Gene

  • GC01M246912
  • GC01M248844
  • GC01M248483

Summaries for OR14I1 Gene

Entrez Gene Summary for OR14I1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR14I1 Gene

OR14I1 (Olfactory Receptor Family 14 Subfamily I Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR14A16.

UniProtKB/Swiss-Prot Summary for OR14I1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR14I1 Gene

Genomics for OR14I1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR14I1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J248686 Enhancer 0.8 Ensembl ENCODE 250.7 -1.4 -1435 0.8 BCLAF1 TRIM22 CTCF RAD21 SMC3 EBF1 IKZF1 ATF2 YY1 EED OR14I1 OR2T1 LYPD9P ENSG00000286015
GH01J248471 Enhancer 0.5 FANTOM5 21.2 +213.7 213736 0.4 ZNF207 MAFG HDGF TARDBP OR2T3 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3
GH01J248731 Enhancer 0.6 ENCODE 11.2 -45.7 -45667 0.2 IKZF1 ZNF592 IRF2 ATF1 EHMT2 NRF1 ZNF143 L3MBTL2 MEIS2 NR2C1 lnc-LYPD8-1 piR-36098-003 OR14I1 LYPD9P ENSG00000286015
GH01J248736 Enhancer 0.4 Ensembl 10.3 -51.8 -51813 1.4 SPI1 ZMYM3 BCOR HMBOX1 OR14I1 OR2T1 LYPD9P ENSG00000229255 HSALNG0012311 piR-36098-003 ENSG00000286015
GH01J248710 Promoter 0.3 Ensembl 11.3 -25.3 -25313 0.8 OR14I1 SH3BP5L ENSG00000276520 AHCYP8 LYPD9P lnc-LYPD8-1 ENSG00000286015
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR14I1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR14I1

Top Transcription factor binding sites by QIAGEN in the OR14I1 gene promoter:
  • CBF(2)
  • NF-Y
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Sox9
  • SRF
  • SRF (504 AA)

Genomic Locations for OR14I1 Gene

Latest Assembly
chr1:248,678,140-248,685,488
(GRCh38/hg38)
Size:
7,349 bases
Orientation:
Minus strand

Previous Assembly
chr1:248,841,441-248,848,789
(GRCh37/hg19 by Entrez Gene)
Size:
7,349 bases
Orientation:
Minus strand

chr1:248,844,628-248,845,629
(GRCh37/hg19 by Ensembl)
Size:
1,002 bases
Orientation:
Minus strand

Genomic View for OR14I1 Gene

Genes around OR14I1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR14I1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR14I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR14I1 Gene

Proteins for OR14I1 Gene

  • Protein details for OR14I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ND48-O14I1_HUMAN
    Recommended name:
    Olfactory receptor 14I1
    Protein Accession:
    A6ND48
    Secondary Accessions:
    • B2RNZ0

    Protein attributes for OR14I1 Gene

    Size:
    311 amino acids
    Molecular mass:
    35175 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR14I1 Gene

Post-translational modifications for OR14I1 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR14I1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR14I1 Gene

Domains & Families for OR14I1 Gene

Gene Families for OR14I1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR14I1 Gene

Suggested Antigen Peptide Sequences for OR14I1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 5, subfamily BU, member 1 (B2RNZ0_HUMAN)
  • Olfactory receptor 5BU1 (O14I1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6ND48

UniProtKB/Swiss-Prot:

O14I1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR14I1: view

Function for OR14I1 Gene

Molecular function for OR14I1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR14I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005515 protein binding IPI 32296183
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR14I1: view
genes like me logo Genes that share phenotypes with OR14I1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR14I1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR14I1 Gene

Localization for OR14I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR14I1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR14I1 gene
Compartment Confidence
plasma membrane 5
endosome 1

Gene Ontology (GO) - Cellular Components for OR14I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR14I1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR14I1 Gene

Pathways & Interactions for OR14I1 Gene

genes like me logo Genes that share pathways with OR14I1: view

Pathways by source for OR14I1 Gene

Interacting Proteins for OR14I1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: A6ND48-O14I1_HUMAN ENSP00000339726 for OR14I1 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for OR14I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR14I1: view

No data available for SIGNOR curated interactions for OR14I1 Gene

Drugs & Compounds for OR14I1 Gene

No Compound Related Data Available

Transcripts for OR14I1 Gene

mRNA/cDNA for OR14I1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR14I1

Alternative Splicing Database (ASD) splice patterns (SP) for OR14I1 Gene

No ASD Table

Relevant External Links for OR14I1 Gene

GeneLoc Exon Structure for
OR14I1

Expression for OR14I1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR14I1 Gene

mRNA differential expression in normal tissues according to GTEx for OR14I1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x14.1), Brain - Anterior cingulate cortex (BA24) (x11.3), and Brain - Cortex (x10.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR14I1

SOURCE GeneReport for Unigene cluster for OR14I1 Gene:

Hs.449973
genes like me logo Genes that share expression patterns with OR14I1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR14I1 Gene

Orthologs for OR14I1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR14I1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC469772 29
  • 98.71 (n)
OR14I1 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100686790 29
  • 83.01 (n)
OR14I1 30
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 55 (a)
OneToMany
-- 30
  • 55 (a)
OneToMany
-- 30
  • 55 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 53 (a)
OneToMany
-- 30
  • 53 (a)
OneToMany
-- 30
  • 52 (a)
OneToMany
-- 30
  • 51 (a)
OneToMany
Chicken
(Gallus gallus)
Aves OR14I1 30
  • 38 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 49 (a)
OneToMany
-- 30
  • 47 (a)
OneToMany
-- 30
  • 47 (a)
OneToMany
-- 30
  • 47 (a)
OneToMany
-- 30
  • 46 (a)
OneToMany
-- 30
  • 46 (a)
OneToMany
-- 30
  • 46 (a)
OneToMany
-- 30
  • 45 (a)
OneToMany
-- 30
  • 43 (a)
OneToMany
-- 30
  • 43 (a)
OneToMany
-- 30
  • 42 (a)
OneToMany
-- 30
  • 42 (a)
OneToMany
Species where no ortholog for OR14I1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR14I1 Gene

ENSEMBL:
Gene Tree for OR14I1 (if available)
TreeFam:
Gene Tree for OR14I1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR14I1: view image
Alliance of Genome Resources:
Additional Orthologs for OR14I1

Paralogs for OR14I1 Gene

(443) SIMAP similar genes for OR14I1 Gene using alignment to 2 proteins:

  • O14I1_HUMAN
  • B2RNZ0_HUMAN
genes like me logo Genes that share paralogs with OR14I1: view

Variants for OR14I1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR14I1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2000390 -- p.Ser170Asn
rs41311583 -- p.Leu84Met
rs4462184 -- p.Val36Ala
rs4509608 -- p.Asp50Asn
rs55871516 -- p.Tyr216Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR14I1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR14I1 Gene

Variant ID Type Subtype PubMed ID
dgv20n17 CNV loss 16327808
dgv631n100 CNV gain 25217958
dgv637n100 CNV loss 25217958
dgv638n100 CNV gain 25217958
dgv642n100 CNV gain 25217958
dgv643n100 CNV gain 25217958
dgv906n54 CNV gain 21841781
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv32631 CNV loss 17666407
esv3589562 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1003091 CNV gain 25217958
nsv1003605 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv428357 CNV loss 18775914
nsv469750 CNV loss 16826518
nsv515858 CNV gain+loss 19592680
nsv5387 CNV deletion 18451855
nsv549740 CNV loss 21841781

Variation tolerance for OR14I1 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR14I1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR14I1
Leiden Open Variation Database (LOVD)
OR14I1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR14I1 Gene

Disorders for OR14I1 Gene

Additional Disease Information for OR14I1

No disorders were found for OR14I1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR14I1 Gene

Publications for OR14I1 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. (PMID: 32126975) Barnes IHA … Frankish A (BMC genomics 2020) 3
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  4. Human olfactory receptor responses to odorants. (PMID: 25977809) Mainland JD … Matsunami H (Scientific data 2015) 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR14I1 Gene

Sources for OR14I1 Gene