Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR14A2 Gene

Aliases for OR14A2 Gene

  • Olfactory Receptor Family 14 Subfamily A Member 2 2 3 5
  • Olfactory Receptor, Family 5, Subfamily AX, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR1-31 3 4
  • Olfactory Receptor 14A2 3 4
  • Olfactory Receptor 5AX1 3 4
  • OR5AX1P 3 4
  • OR5AX1 3 4
  • Olfactory Receptor, Family 5, Subfamily AX, Member 1 2
  • Olfactory Receptor, Family 14, Subfamily A, Member 2 2

External Ids for OR14A2 Gene

Previous HGNC Symbols for OR14A2 Gene

  • OR5AX1P
  • OR5AX1

Previous GeneCards Identifiers for OR14A2 Gene

  • GC01M245953
  • GC01M247886

Summaries for OR14A2 Gene

Entrez Gene Summary for OR14A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR14A2 Gene

OR14A2 (Olfactory Receptor Family 14 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR14A16.

UniProtKB/Swiss-Prot Summary for OR14A2 Gene

Additional gene information for OR14A2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR14A2 Gene

Genomics for OR14A2 Gene

Genomic Locations for OR14A2 Gene

Genomic Locations for OR14A2 Gene
chr1:247,722,899-247,724,243
(GRCh38/hg38)
Size:
1,345 bases
Orientation:
Minus strand
chr1:247,886,201-247,887,545
(GRCh37/hg19)
Size:
1,345 bases
Orientation:
Minus strand

Genomic View for OR14A2 Gene

Genes around OR14A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR14A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR14A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR14A2 Gene

No data available for GeneHancer (GH) Regulatory Elements for OR14A2 Gene

Proteins for OR14A2 Gene

  • Protein details for OR14A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R54-O14A2_HUMAN
    Recommended name:
    Olfactory receptor 14A2
    Protein Accession:
    Q96R54

    Protein attributes for OR14A2 Gene

    Size:
    314 amino acids
    Molecular mass:
    34780 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR14A2 Gene

Post-translational modifications for OR14A2 Gene

  • Glycosylation at Asn3 and Asn83

Other Protein References for OR14A2 Gene

No data available for DME Specific Peptides for OR14A2 Gene

Domains & Families for OR14A2 Gene

Gene Families for OR14A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR14A2 Gene

Suggested Antigen Peptide Sequences for OR14A2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-31 (O14A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96R54

UniProtKB/Swiss-Prot:

O14A2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR14A2: view

Function for OR14A2 Gene

Molecular function for OR14A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR14A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR14A2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR14A2 Gene

Localization for OR14A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR14A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR14A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR14A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR14A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR14A2 Gene

Pathways & Interactions for OR14A2 Gene

genes like me logo Genes that share pathways with OR14A2: view

Pathways by source for OR14A2 Gene

Interacting Proteins for OR14A2 Gene

Gene Ontology (GO) - Biological Process for OR14A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR14A2: view

No data available for SIGNOR curated interactions for OR14A2 Gene

Drugs & Compounds for OR14A2 Gene

No Compound Related Data Available

Transcripts for OR14A2 Gene

mRNA/cDNA for OR14A2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR14A2 Gene

No ASD Table

Relevant External Links for OR14A2 Gene

GeneLoc Exon Structure for
OR14A2
ECgene alternative splicing isoforms for
OR14A2

Expression for OR14A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR14A2 Gene

mRNA differential expression in normal tissues according to GTEx for OR14A2 Gene

This gene is overexpressed in Testis (x52.3).

Protein differential expression in normal tissues from HIPED for OR14A2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR14A2 Gene



Protein tissue co-expression partners for OR14A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR14A2 Gene:

OR14A2
genes like me logo Genes that share expression patterns with OR14A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR14A2 Gene

Orthologs for OR14A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR14A2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Or14a260 49 Olfr307 33
  • 72 (a)
OneToMany
Or14a259 49 Olfr305 33
  • 71 (a)
OneToMany
Or14a258 49 Olfr304 33
  • 69 (a)
OneToMany
Or14a257 49 Olfr298 33
  • 66 (a)
OneToMany
Or14a256 49 Olfr294 33
  • 64 (a)
OneToMany
Or14o1-ps 49 Olfr306-ps1
  • chr7:86,353,087-86,353,719
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 63 (a)
OneToMany
-- 33
  • 61 (a)
OneToMany
-- 33
  • 61 (a)
OneToMany
-- 33
  • 60 (a)
OneToMany
-- 33
  • 60 (a)
OneToMany
-- 33
  • 60 (a)
OneToMany
-- 33
  • 60 (a)
OneToMany
-- 33
  • 58 (a)
OneToMany
-- 33
  • 57 (a)
OneToMany
-- 33
  • 56 (a)
OneToMany
-- 33
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 58 (a)
ManyToMany
-- 33
  • 57 (a)
ManyToMany
-- 33
  • 53 (a)
ManyToMany
-- 33
  • 52 (a)
ManyToMany
-- 33
  • 52 (a)
ManyToMany
-- 33
  • 51 (a)
ManyToMany
-- 33
  • 51 (a)
ManyToMany
-- 33
  • 51 (a)
ManyToMany
-- 33
  • 51 (a)
ManyToMany
-- 33
  • 51 (a)
ManyToMany
-- 33
  • 50 (a)
ManyToMany
-- 33
  • 50 (a)
ManyToMany
-- 33
  • 50 (a)
ManyToMany
-- 33
  • 44 (a)
ManyToMany
Species where no ortholog for OR14A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR14A2 Gene

ENSEMBL:
Gene Tree for OR14A2 (if available)
TreeFam:
Gene Tree for OR14A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR14A2: view image

Paralogs for OR14A2 Gene

(443) SIMAP similar genes for OR14A2 Gene using alignment to 1 proteins:

  • O14A2_HUMAN

Pseudogenes.org Pseudogenes for OR14A2 Gene

genes like me logo Genes that share paralogs with OR14A2: view

Variants for OR14A2 Gene

Sequence variations from dbSNP and Humsavar for OR14A2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000096821 -- 247,740,706(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000350820 -- 247,725,386(-) A/G intron_variant
rs1000390424 -- 247,725,112(-) T/C intron_variant
rs1000419234 -- 247,724,757(-) A/G intron_variant
rs1000585150 -- 247,741,480(-) A/G genic_upstream_transcript_variant, intron_variant

Variation tolerance for OR14A2 Gene

Gene Damage Index Score: 6.32; 76.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR14A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR14A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR14A2 Gene

Disorders for OR14A2 Gene

Additional Disease Information for OR14A2

No disorders were found for OR14A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR14A2 Gene

Publications for OR14A2 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 56
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 4 56

Products for OR14A2 Gene

Sources for OR14A2 Gene