Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR13J1 Gene

Aliases for OR13J1 Gene

  • Olfactory Receptor Family 13 Subfamily J Member 1 2 3 5
  • Olfactory Receptor OR9-2 3 4
  • Olfactory Receptor 13J1 3 4
  • Olfactory Receptor, Family 13, Subfamily J, Member 1 2
  • OR13J1 5
  • OR9-2 3

External Ids for OR13J1 Gene

Previous GeneCards Identifiers for OR13J1 Gene

  • GC09U990176
  • GC09M035860

Summaries for OR13J1 Gene

Entrez Gene Summary for OR13J1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR13J1 Gene

OR13J1 (Olfactory Receptor Family 13 Subfamily J Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C9.

UniProtKB/Swiss-Prot Summary for OR13J1 Gene

Gene Wiki entry for OR13J1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR13J1 Gene

Genomics for OR13J1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR13J1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J035868 Enhancer 0.5 Ensembl 250.7 +1.3 1300 1.8 NFIC CEBPB CTCF ATF4 ATF3 MNT CEBPG HSALNG0070962 OR13J1 TMEM8B TPM2 FAM221B L13304-035
GH09J035904 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.1 -38.2 -38245 8.7 ZNF654 JUND ZMYM3 ZNF10 POLR2A NFIC ZIC2 YY1 CEBPB REST SPAAR NONHSAG052133.2 HRCT1 TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 NPR2 ENSG00000227388
GH09J035914 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 10.8 -46.7 -46740 7.5 NCOR1 IKZF1 ZNF592 NFIC YY1 REST PLRG1 MBD2 TBP MCM3 HSALNG0070967 lnc-HRCT1-6 PIGO TLN1 GBA2 SPAAR ARHGEF39 CLTA RECK FANCG
GH09J035537 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 +331.6 331571 3.9 POLR2A SIN3A TAF1 BHLHE40 GATA2 CHD2 RAD21 CEBPB RUSC2 FAM166B OR13J1 piR-50443-374 piR-38327
GH09J035847 Enhancer 0.7 ENCODE 12.1 +22.3 22264 2 BCLAF1 SP1 BCL11A EBF1 MAX ASH2L MTA3 ATF2 TCF12 PKNOX1 TMEM8B OR13J1 NDUFA5P4 NPR2 ENSG00000227388 SPAG8 HINT2 GBA2 TLN1 CREB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR13J1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR13J1

Top Transcription factor binding sites by QIAGEN in the OR13J1 gene promoter:
  • E47
  • NF-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • PPAR-alpha
  • Tal-1

Genomic Locations for OR13J1 Gene

Latest Assembly
chr9:35,869,263-35,870,601
(GRCh38/hg38)
Size:
1,339 bases
Orientation:
Minus strand

Previous Assembly
chr9:35,869,460-35,870,398
(GRCh37/hg19 by Entrez Gene)
Size:
939 bases
Orientation:
Minus strand

chr9:35,869,375-35,870,461
(GRCh37/hg19 by Ensembl)
Size:
1,087 bases
Orientation:
Minus strand

Genomic View for OR13J1 Gene

Genes around OR13J1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR13J1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR13J1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR13J1 Gene

Proteins for OR13J1 Gene

  • Protein details for OR13J1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGT2-O13J1_HUMAN
    Recommended name:
    Olfactory receptor 13J1
    Protein Accession:
    Q8NGT2
    Secondary Accessions:
    • B2RN66
    • Q6IF20
    • Q96R40

    Protein attributes for OR13J1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34689 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR13J1 Gene

Post-translational modifications for OR13J1 Gene

  • Glycosylation at Asn5 and Asn191
  • Modification sites at PhosphoSitePlus

Other Protein References for OR13J1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR13J1 Gene

Domains & Families for OR13J1 Gene

Gene Families for OR13J1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR13J1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR13J1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR9-2 (O13J1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGT2

UniProtKB/Swiss-Prot:

O13J1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR13J1: view

Function for OR13J1 Gene

Molecular function for OR13J1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR13J1 Gene

Gene Ontology (GO) - Molecular Function for OR13J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR13J1: view

Phenotypes for OR13J1 Gene

genes like me logo Genes that share phenotypes with OR13J1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13J1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR13J1 Gene

Localization for OR13J1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR13J1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR13J1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR13J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR13J1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR13J1 Gene

Pathways & Interactions for OR13J1 Gene

genes like me logo Genes that share pathways with OR13J1: view

Pathways by source for OR13J1 Gene

Interacting Proteins for OR13J1 Gene

Gene Ontology (GO) - Biological Process for OR13J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR13J1: view

No data available for SIGNOR curated interactions for OR13J1 Gene

Drugs & Compounds for OR13J1 Gene

No Compound Related Data Available

Transcripts for OR13J1 Gene

mRNA/cDNA for OR13J1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13J1

Alternative Splicing Database (ASD) splice patterns (SP) for OR13J1 Gene

No ASD Table

Relevant External Links for OR13J1 Gene

GeneLoc Exon Structure for
OR13J1

Expression for OR13J1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR13J1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR13J1

SOURCE GeneReport for Unigene cluster for OR13J1 Gene:

Hs.527480

Evidence on tissue expression from TISSUES for OR13J1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with OR13J1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR13J1 Gene

Orthologs for OR13J1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR13J1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC473225 29
  • 99.14 (n)
OR13J1 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC611969 29
  • 86.75 (n)
OR13J1 30
  • 85 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC618828 29
  • 86.75 (n)
-- 30
  • 85 (a)
OneToMany
-- 30
  • 84 (a)
OneToMany
-- 30
  • 84 (a)
OneToMany
-- 30
  • 82 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or13j1 45 Olfr71 29 16 30
  • 85.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr834 29
  • 85.04 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR13J1 30
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 39 (a)
ManyToMany
Species where no ortholog for OR13J1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR13J1 Gene

ENSEMBL:
Gene Tree for OR13J1 (if available)
TreeFam:
Gene Tree for OR13J1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR13J1: view image
Alliance of Genome Resources:
Additional Orthologs for OR13J1

Paralogs for OR13J1 Gene

(442) SIMAP similar genes for OR13J1 Gene using alignment to 1 proteins:

  • O13J1_HUMAN
genes like me logo Genes that share paralogs with OR13J1: view

Variants for OR13J1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR13J1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs7044405 -- p.His133Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR13J1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR13J1 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv831546 CNV loss 17160897

Variation tolerance for OR13J1 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 29.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR13J1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR13J1
Leiden Open Variation Database (LOVD)
OR13J1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR13J1 Gene

Disorders for OR13J1 Gene

Additional Disease Information for OR13J1

No disorders were found for OR13J1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR13J1 Gene

Publications for OR13J1 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR13J1 Gene

Sources for OR13J1 Gene