Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR13G1 Gene

Aliases for OR13G1 Gene

  • Olfactory Receptor Family 13 Subfamily G Member 1 2 3 5
  • Olfactory Receptor OR1-37 3 4
  • Olfactory Receptor 13G1 3 4
  • Olfactory Receptor, Family 13, Subfamily G, Member 1 2
  • OR1-37 3

External Ids for OR13G1 Gene

Previous GeneCards Identifiers for OR13G1 Gene

  • GC01U990418
  • GC01M244161
  • GC01M245902
  • GC01M247835

Summaries for OR13G1 Gene

Entrez Gene Summary for OR13G1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR13G1 Gene

OR13G1 (Olfactory Receptor Family 13 Subfamily G Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1J2.

UniProtKB/Swiss-Prot Summary for OR13G1 Gene

Gene Wiki entry for OR13G1 Gene

Additional gene information for OR13G1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR13G1 Gene

Genomics for OR13G1 Gene

GeneHancer (GH) Regulatory Elements for OR13G1 Gene

Promoters and enhancers for OR13G1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247854 Enhancer 1.3 FANTOM5 Ensembl ENCODE 9.9 -175.5 -175492 2.1 ZBTB5 ZBTB11 MYC CTBP1 NCOR1 NEUROD1 ZNF316 NFIC ARNT FOSL1 TRIM58 OR2T8 OR13G1 OR2W3 OR11L1
GH01J247852 Enhancer 0.5 Ensembl 9.9 -173.0 -172962 1.8 ZNF316 MAFF MAFK SPI1 NFE2 MAFG HMBOX1 EMSY TRIM58 OR2AJ1 OR2T8 OR13G1 OR11L1
GH01J247647 Enhancer 0.3 ENCODE 11.4 +31.7 31660 0.9 NANOG OR13G1 OR2G3 OR2T8 TRIM58 OR3D1P ENSG00000235749 LOC102724446
GH01J247741 Enhancer 0.3 ENCODE 10.5 -62.2 -62203 1.3 GATA3 OR13G1 OR14A16 ENSG00000235749 OR14K1 lnc-OR1C1-1
GH01J247641 Enhancer 0.2 Ensembl 11.2 +37.4 37438 0.2 ENSG00000236817 LOC102724446 OR13G1 OR2G3 OR2G2 ENSG00000235749 OR3D1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR13G1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR13G1

Top Transcription factor binding sites by QIAGEN in the OR13G1 gene promoter:
  • Bach1
  • Brachyury
  • Cart-1
  • GATA-1
  • GR
  • GR-alpha
  • HNF-4alpha1
  • LCR-F1
  • Nkx6-1
  • STAT5A

Genomic Locations for OR13G1 Gene

Genomic Locations for OR13G1 Gene
chr1:247,670,812-247,679,739
(GRCh38/hg38)
Size:
8,928 bases
Orientation:
Minus strand
chr1:247,835,320-247,836,365
(GRCh37/hg19)
Size:
1,046 bases
Orientation:
Minus strand

Genomic View for OR13G1 Gene

Genes around OR13G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR13G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR13G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR13G1 Gene

Proteins for OR13G1 Gene

  • Protein details for OR13G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGZ3-O13G1_HUMAN
    Recommended name:
    Olfactory receptor 13G1
    Protein Accession:
    Q8NGZ3
    Secondary Accessions:
    • B2RN80
    • Q5T2T2
    • Q6IF86

    Protein attributes for OR13G1 Gene

    Size:
    307 amino acids
    Molecular mass:
    34672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR13G1 Gene

Post-translational modifications for OR13G1 Gene

  • Glycosylation at Asn2
  • Modification sites at PhosphoSitePlus

Other Protein References for OR13G1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR13G1 Gene

Domains & Families for OR13G1 Gene

Gene Families for OR13G1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR13G1 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR13G1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-37 (O13G1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGZ3

UniProtKB/Swiss-Prot:

O13G1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR13G1: view

Function for OR13G1 Gene

Molecular function for OR13G1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR13G1 Gene

Gene Ontology (GO) - Molecular Function for OR13G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR13G1: view
genes like me logo Genes that share phenotypes with OR13G1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR13G1 Gene

Localization for OR13G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR13G1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR13G1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR13G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR13G1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR13G1 Gene

Pathways & Interactions for OR13G1 Gene

genes like me logo Genes that share pathways with OR13G1: view

Pathways by source for OR13G1 Gene

Interacting Proteins for OR13G1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000352717 Q8NGZ3-O13G1_HUMAN for OR13G1 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for OR13G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR13G1: view

No data available for SIGNOR curated interactions for OR13G1 Gene

Drugs & Compounds for OR13G1 Gene

No Compound Related Data Available

Transcripts for OR13G1 Gene

mRNA/cDNA for OR13G1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR13G1 Gene

No ASD Table

Relevant External Links for OR13G1 Gene

GeneLoc Exon Structure for
OR13G1

Expression for OR13G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR13G1 Gene

mRNA differential expression in normal tissues according to GTEx for OR13G1 Gene

This gene is overexpressed in Testis (x27.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR13G1

SOURCE GeneReport for Unigene cluster for OR13G1 Gene:

Hs.553834
genes like me logo Genes that share expression patterns with OR13G1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR13G1 Gene

Orthologs for OR13G1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR13G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469749 30
  • 99.24 (n)
OR13G1 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR13G1 31 30
  • 85.45 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Or13g1 47 Olfr309 17 31 30
  • 84.42 (n)
rat
(Rattus norvegicus)
Mammalia Olr12 30
  • 83.12 (n)
oppossum
(Monodelphis domestica)
Mammalia OR13G1 31
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 46 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
Species where no ortholog for OR13G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR13G1 Gene

ENSEMBL:
Gene Tree for OR13G1 (if available)
TreeFam:
Gene Tree for OR13G1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR13G1: view image

Paralogs for OR13G1 Gene

(451) SIMAP similar genes for OR13G1 Gene using alignment to 1 proteins:

  • O13G1_HUMAN
genes like me logo Genes that share paralogs with OR13G1: view

Variants for OR13G1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR13G1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
767774 Benign: not provided 247,672,772(-) T/A SYNONYMOUS_VARIANT
rs1151640 - p.Ile132Val
rs28446289 - p.Arg224Cys
rs28556931 - p.Met146Leu
rs28711149 - p.Lys46Ile

Additional dbSNP identifiers (rs#s) for OR13G1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR13G1 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv5310 CNV deletion 18451855
nsv998451 CNV loss 25217958

Variation tolerance for OR13G1 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.79; 97.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR13G1 Gene

Human Gene Mutation Database (HGMD)
OR13G1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR13G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR13G1 Gene

Disorders for OR13G1 Gene

Additional Disease Information for OR13G1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR13G1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR13G1 Gene

Publications for OR13G1 Gene

  1. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. (PMID: 18599554) van der Net JB … Sijbrands EJ (European heart journal 2008) 3 23 41 54
  2. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PMID: 19709766) Koch W … Kastrati A (International journal of cardiology 2011) 3 41 54
  3. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PMID: 19056482) Yoshida T … Yamada Y (Genomics 2009) 3 41 54
  4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 41 54
  5. Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia. (PMID: 19166692) van der Net JB … Steyerberg EW (The American journal of cardiology 2009) 3 41 54

Products for OR13G1 Gene

Sources for OR13G1 Gene