Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR13D1 Gene

Aliases for OR13D1 Gene

  • Olfactory Receptor Family 13 Subfamily D Member 1 2 3 5
  • Olfactory Receptor OR9-15 3 4
  • Olfactory Receptor 13D1 3 4
  • Olfactory Receptor, Family 13, Subfamily D, Member 1 2
  • OR9-15 3
  • OR13D1 5

External Ids for OR13D1 Gene

Previous GeneCards Identifiers for OR13D1 Gene

  • GC09U990158
  • GC09P102837
  • GC09P104536
  • GC09P106496
  • GC09P107456

Summaries for OR13D1 Gene

Entrez Gene Summary for OR13D1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR13D1 Gene

OR13D1 (Olfactory Receptor Family 13 Subfamily D Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2K2.

UniProtKB/Swiss-Prot Summary for OR13D1 Gene

Gene Wiki entry for OR13D1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR13D1 Gene

Genomics for OR13D1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR13D1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J104738 Enhancer 0.3 Ensembl 10.6 +44.3 44322 0.2 NR2F6 NR2F1 OR13D1 HSALNG0073388-001 NIPSNAP3A LOC107987105 OR13D3P
GH09J104740 Enhancer 0.3 Ensembl 10.7 +46.7 46721 1 CEBPB OR13D1 NIPSNAP3A HSALNG0073388-001 LOC107987105 OR13D3P
GH09J104741 Enhancer 0.3 Ensembl 10.6 +45.9 45922 0.2 CEBPB OR13D1 HSALNG0073388-001 NIPSNAP3A LOC107987105 OR13D3P
GH09J104586 Enhancer 0.2 ENCODE 10 -107.7 -107684 0.2 NIPSNAP3A OR13C3 OR13D1 OR13D2P OR13C5 piR-31199-381 OR13C8 HSALNG0073388-001
GH09J104745 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.2 +53.1 53108 4.2 NCOR1 MYC IKZF1 KLF9 POLR2A NFIC ZBTB10 YY1 KLF11 SMAD5 NIPSNAP3A HSALNG0073388-001 LOC107987105 ABCA1 OR13D3P OR13D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR13D1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR13D1

Top Transcription factor binding sites by QIAGEN in the OR13D1 gene promoter:
  • ITF-2
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for OR13D1 Gene

Latest Assembly
chr9:104,694,379-104,695,485
(GRCh38/hg38)
Size:
1,107 bases
Orientation:
Plus strand

Previous Assembly
chr9:107,456,703-107,457,743
(GRCh37/hg19 by Entrez Gene)
Size:
1,041 bases
Orientation:
Plus strand

chr9:107,456,660-107,457,766
(GRCh37/hg19 by Ensembl)
Size:
1,107 bases
Orientation:
Plus strand

Genomic View for OR13D1 Gene

Genes around OR13D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR13D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR13D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR13D1 Gene

Proteins for OR13D1 Gene

  • Protein details for OR13D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGV5-O13D1_HUMAN
    Recommended name:
    Olfactory receptor 13D1
    Protein Accession:
    Q8NGV5
    Secondary Accessions:
    • B9EIS1
    • Q6IFL1

    Protein attributes for OR13D1 Gene

    Size:
    346 amino acids
    Molecular mass:
    39125 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR13D1 Gene

Post-translational modifications for OR13D1 Gene

  • Glycosylation at Asn37 and Asn300
  • Modification sites at PhosphoSitePlus

Other Protein References for OR13D1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR13D1 Gene

Domains & Families for OR13D1 Gene

Gene Families for OR13D1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR13D1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR13D1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR9-15 (O13D1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGV5

UniProtKB/Swiss-Prot:

O13D1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR13D1: view

Function for OR13D1 Gene

Molecular function for OR13D1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR13D1 Gene

Gene Ontology (GO) - Molecular Function for OR13D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR13D1: view
genes like me logo Genes that share phenotypes with OR13D1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13D1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR13D1 Gene

Localization for OR13D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR13D1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR13D1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR13D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR13D1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR13D1 Gene

Pathways & Interactions for OR13D1 Gene

genes like me logo Genes that share pathways with OR13D1: view

Pathways by source for OR13D1 Gene

Interacting Proteins for OR13D1 Gene

Gene Ontology (GO) - Biological Process for OR13D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR13D1: view

No data available for SIGNOR curated interactions for OR13D1 Gene

Drugs & Compounds for OR13D1 Gene

No Compound Related Data Available

Transcripts for OR13D1 Gene

mRNA/cDNA for OR13D1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13D1

Alternative Splicing Database (ASD) splice patterns (SP) for OR13D1 Gene

No ASD Table

Relevant External Links for OR13D1 Gene

GeneLoc Exon Structure for
OR13D1

Expression for OR13D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR13D1 Gene

mRNA differential expression in normal tissues according to GTEx for OR13D1 Gene

This gene is overexpressed in Testis (x17.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR13D1

SOURCE GeneReport for Unigene cluster for OR13D1 Gene:

Hs.553683
genes like me logo Genes that share expression patterns with OR13D1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR13D1 Gene

Orthologs for OR13D1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR13D1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC464628 29
  • 99.03 (n)
OR13D1 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 88 (a)
OneToMany
-- 30
  • 87 (a)
OneToMany
LOC610556 29
  • 86.22 (n)
-- 30
  • 84 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or13d1 45 Olfr270 29 16 30
  • 84.3 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr853 29
  • 84.19 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 78 (a)
OneToMany
-- 30
  • 78 (a)
OneToMany
-- 30
  • 75 (a)
OneToMany
-- 30
  • 73 (a)
OneToMany
-- 30
  • 72 (a)
OneToMany
-- 30
  • 72 (a)
OneToMany
-- 30
  • 70 (a)
OneToMany
-- 30
  • 69 (a)
OneToMany
-- 30
  • 68 (a)
OneToMany
-- 30
  • 65 (a)
OneToMany
OPOR64 30
  • 65 (a)
OneToMany
-- 30
  • 65 (a)
OneToMany
-- 30
  • 63 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia OR13D1 30
  • 71 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR13D1 30
  • 62 (a)
OneToOne
Species where no ortholog for OR13D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR13D1 Gene

ENSEMBL:
Gene Tree for OR13D1 (if available)
TreeFam:
Gene Tree for OR13D1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR13D1: view image
Alliance of Genome Resources:
Additional Orthologs for OR13D1

Paralogs for OR13D1 Gene

(445) SIMAP similar genes for OR13D1 Gene using alignment to 1 proteins:

  • O13D1_HUMAN

Pseudogenes.org Pseudogenes for OR13D1 Gene

genes like me logo Genes that share paralogs with OR13D1: view

Variants for OR13D1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR13D1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs10761073 -- p.Ser277Leu
rs10820709 -- p.Gln191His
rs10991359 -- p.Phe21Leu
rs13294411 -- p.Leu64Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR13D1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR13D1 Gene

Variant ID Type Subtype PubMed ID
dgv2175e212 CNV loss 25503493
esv3573336 CNV loss 25503493
esv3891705 CNV loss 25118596
esv3891706 CNV gain 25118596

Variation tolerance for OR13D1 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.31; 81.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR13D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR13D1
Leiden Open Variation Database (LOVD)
OR13D1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR13D1 Gene

Disorders for OR13D1 Gene

Additional Disease Information for OR13D1

No disorders were found for OR13D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR13D1 Gene

Publications for OR13D1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR13D1 Gene

Sources for OR13D1 Gene