Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR13C8 Gene

Aliases for OR13C8 Gene

  • Olfactory Receptor Family 13 Subfamily C Member 8 2 3 5
  • Olfactory Receptor 13C8 3 4
  • Olfactory Receptor, Family 13, Subfamily C, Member 8 2
  • Olfactory Receptor OR9-10 Pseudogene 3
  • OR9-10 3
  • OR13C8 5
  • OR37H 3

External Ids for OR13C8 Gene

Previous GeneCards Identifiers for OR13C8 Gene

  • GC09U990181
  • GC09P102712
  • GC09P104412
  • GC09P106371
  • GC09P107331

Summaries for OR13C8 Gene

Entrez Gene Summary for OR13C8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR13C8 Gene

OR13C8 (Olfactory Receptor Family 13 Subfamily C Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2S2.

UniProtKB/Swiss-Prot Summary for OR13C8 Gene

Gene Wiki entry for OR13C8 Gene

Additional gene information for OR13C8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR13C8 Gene

Genomics for OR13C8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR13C8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J104971 Enhancer 0.2 FANTOM5 2.4 +402.8 402763 0 OR13C3 SLC44A1 OR13C8 lnc-ABCA1-9 lnc-NIPSNAP3B-5 CT70 ABCA1 MN298678-148
GH09J104586 Enhancer 0.2 ENCODE 0.4 +17.5 17527 0.2 NIPSNAP3A OR13C3 OR13D1 OR13D2P OR13C5 piR-31199-381 OR13C8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR13C8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR13C8

Top Transcription factor binding sites by QIAGEN in the OR13C8 gene promoter:
  • CP2
  • FOXL1
  • GATA-1
  • IRF-1
  • MyoD
  • Nkx6-1
  • POU3F2
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for OR13C8 Gene

Genomic Locations for OR13C8 Gene
chr9:104,569,168-104,570,130
(GRCh38/hg38)
Size:
963 bases
Orientation:
Plus strand
chr9:107,331,449-107,332,411
(GRCh37/hg19)
Size:
963 bases
Orientation:
Plus strand

Genomic View for OR13C8 Gene

Genes around OR13C8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR13C8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR13C8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR13C8 Gene

Proteins for OR13C8 Gene

  • Protein details for OR13C8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGS7-O13C8_HUMAN
    Recommended name:
    Olfactory receptor 13C8
    Protein Accession:
    Q8NGS7
    Secondary Accessions:
    • Q5VVG0
    • Q96R44

    Protein attributes for OR13C8 Gene

    Size:
    320 amino acids
    Molecular mass:
    35294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR13C8 Gene

Post-translational modifications for OR13C8 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR13C8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR13C8 Gene

Domains & Families for OR13C8 Gene

Gene Families for OR13C8 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR13C8 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR13C8 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 13C8 (O13C8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGS7

UniProtKB/Swiss-Prot:

O13C8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR13C8: view

Function for OR13C8 Gene

Molecular function for OR13C8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR13C8 Gene

Gene Ontology (GO) - Molecular Function for OR13C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR13C8: view

Phenotypes for OR13C8 Gene

genes like me logo Genes that share phenotypes with OR13C8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13C8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR13C8 Gene

Localization for OR13C8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR13C8 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR13C8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR13C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR13C8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR13C8 Gene

Pathways & Interactions for OR13C8 Gene

genes like me logo Genes that share pathways with OR13C8: view

Pathways by source for OR13C8 Gene

Interacting Proteins for OR13C8 Gene

Gene Ontology (GO) - Biological Process for OR13C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR13C8: view

No data available for SIGNOR curated interactions for OR13C8 Gene

Drugs & Compounds for OR13C8 Gene

No Compound Related Data Available

Transcripts for OR13C8 Gene

mRNA/cDNA for OR13C8 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13C8

Alternative Splicing Database (ASD) splice patterns (SP) for OR13C8 Gene

No ASD Table

Relevant External Links for OR13C8 Gene

GeneLoc Exon Structure for
OR13C8

Expression for OR13C8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR13C8 Gene

Protein differential expression in normal tissues from HIPED for OR13C8 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR13C8 Gene



Protein tissue co-expression partners for OR13C8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR13C8

SOURCE GeneReport for Unigene cluster for OR13C8 Gene:

Hs.553599
genes like me logo Genes that share expression patterns with OR13C8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR13C8 Gene

Orthologs for OR13C8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR13C8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC473003 30
  • 98.96 (n)
OR13C8 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100685557 30
  • 88.89 (n)
OR13C8 31
  • 86 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR13C8 30 31
  • 86.73 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or13c25 46 Olfr272 30 17 31
  • 81.97 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr851 30
  • 80.34 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR13C8 31
  • 73 (a)
OneToOne
Species where no ortholog for OR13C8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR13C8 Gene

ENSEMBL:
Gene Tree for OR13C8 (if available)
TreeFam:
Gene Tree for OR13C8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR13C8: view image

Paralogs for OR13C8 Gene

(453) SIMAP similar genes for OR13C8 Gene using alignment to 1 proteins:

  • O13C8_HUMAN

Pseudogenes.org Pseudogenes for OR13C8 Gene

genes like me logo Genes that share paralogs with OR13C8: view

Variants for OR13C8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR13C8 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs7026705 - p.Ala19Asp

Additional dbSNP identifiers (rs#s) for OR13C8 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR13C8 Gene

Variant ID Type Subtype PubMed ID
esv3891705 CNV loss 25118596
esv3891706 CNV gain 25118596
nsv831677 CNV gain 17160897

Variation tolerance for OR13C8 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR13C8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR13C8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR13C8 Gene

Disorders for OR13C8 Gene

No disorders were found for OR13C8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR13C8 Gene

Publications for OR13C8 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3

Products for OR13C8 Gene

Sources for OR13C8 Gene