Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR13C5 Gene

Aliases for OR13C5 Gene

  • Olfactory Receptor Family 13 Subfamily C Member 5 2 3 5
  • Olfactory Receptor OR9-11 3 4
  • Olfactory Receptor 13C5 3 4
  • Olfactory Receptor, Family 13, Subfamily C, Member 5 2
  • OR9-11 3
  • OR13C5 5

External Ids for OR13C5 Gene

Previous GeneCards Identifiers for OR13C5 Gene

  • GC09U990184
  • GC09M102741
  • GC09M104440
  • GC09M106400
  • GC09M107360

Summaries for OR13C5 Gene

Entrez Gene Summary for OR13C5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR13C5 Gene

OR13C5 (Olfactory Receptor Family 13 Subfamily C Member 5) is a Protein Coding gene. Diseases associated with OR13C5 include Developmental And Epileptic Encephalopathy 4. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C2.

UniProtKB/Swiss-Prot Summary for OR13C5 Gene

Gene Wiki entry for OR13C5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR13C5 Gene

Genomics for OR13C5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR13C5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J104586 Enhancer 0.2 ENCODE 0.4 +12.7 12718 0.2 NIPSNAP3A OR13C3 OR13D1 OR13D2P OR13C5 piR-31199-381 OR13C8 HSALNG0073388-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR13C5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR13C5

Top Transcription factor binding sites by QIAGEN in the OR13C5 gene promoter:
  • AhR
  • aMEF-2
  • Arnt
  • CP2
  • Lhx3a
  • LHX3b
  • MEF-2A
  • POU2F1
  • POU2F1a
  • YY1

Genomic Locations for OR13C5 Gene

Latest Assembly
chr9:104,598,457-104,599,413
(GRCh38/hg38)
Size:
957 bases
Orientation:
Minus strand

Previous Assembly
chr9:107,360,738-107,361,694
(GRCh37/hg19 by Entrez Gene)
Size:
957 bases
Orientation:
Minus strand

Genomic View for OR13C5 Gene

Genes around OR13C5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR13C5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR13C5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR13C5 Gene

Proteins for OR13C5 Gene

  • Protein details for OR13C5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGS8-O13C5_HUMAN
    Recommended name:
    Olfactory receptor 13C5
    Protein Accession:
    Q8NGS8
    Secondary Accessions:
    • B2RNE5
    • B9EGW5
    • Q6IF53

    Protein attributes for OR13C5 Gene

    Size:
    318 amino acids
    Molecular mass:
    35796 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR13C5 Gene

Post-translational modifications for OR13C5 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR13C5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR13C5 Gene

Domains & Families for OR13C5 Gene

Gene Families for OR13C5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR13C5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR13C5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR9-11 (O13C5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGS8

UniProtKB/Swiss-Prot:

O13C5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR13C5: view

Function for OR13C5 Gene

Molecular function for OR13C5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR13C5 Gene

Gene Ontology (GO) - Molecular Function for OR13C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR13C5: view

Phenotypes for OR13C5 Gene

GenomeRNAi human phenotypes for OR13C5:
genes like me logo Genes that share phenotypes with OR13C5: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13C5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR13C5 Gene

Localization for OR13C5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR13C5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR13C5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR13C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR13C5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR13C5 Gene

Pathways & Interactions for OR13C5 Gene

genes like me logo Genes that share pathways with OR13C5: view

Pathways by source for OR13C5 Gene

Interacting Proteins for OR13C5 Gene

Gene Ontology (GO) - Biological Process for OR13C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR13C5: view

No data available for SIGNOR curated interactions for OR13C5 Gene

Drugs & Compounds for OR13C5 Gene

No Compound Related Data Available

Transcripts for OR13C5 Gene

mRNA/cDNA for OR13C5 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13C5

Alternative Splicing Database (ASD) splice patterns (SP) for OR13C5 Gene

No ASD Table

Relevant External Links for OR13C5 Gene

GeneLoc Exon Structure for
OR13C5

Expression for OR13C5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR13C5 Gene

mRNA differential expression in normal tissues according to GTEx for OR13C5 Gene

This gene is overexpressed in Pituitary (x13.1), Brain - Hypothalamus (x4.4), Brain - Cortex (x4.1), and Brain - Putamen (basal ganglia) (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR13C5

SOURCE GeneReport for Unigene cluster for OR13C5 Gene:

Hs.553598
genes like me logo Genes that share expression patterns with OR13C5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR13C5 Gene

Orthologs for OR13C5 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for OR13C5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC473005 29
  • 98.11 (n)
Species where no ortholog for OR13C5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR13C5 Gene

ENSEMBL:
Gene Tree for OR13C5 (if available)
TreeFam:
Gene Tree for OR13C5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR13C5: view image
Alliance of Genome Resources:
Additional Orthologs for OR13C5

Paralogs for OR13C5 Gene

(447) SIMAP similar genes for OR13C5 Gene using alignment to 1 proteins:

  • O13C5_HUMAN
genes like me logo Genes that share paralogs with OR13C5: view

Variants for OR13C5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR13C5 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs4629933 Benign: not provided 104,599,158(-) G/Cp.Leu86Val
NM_001004482.1(OR13C5):c.256C>G (p.Leu86Val)
MISSENSE
rs7025570 Benign: not provided 104,599,179(-) G/A
NM_001004482.1(OR13C5):c.235C>T (p.Pro79Ser)
MISSENSE
rs73508187 Benign: not provided 104,598,728(-) C/G
NM_001004482.1(OR13C5):c.686G>C (p.Ser229Thr)
MISSENSE
rs75081605 Benign/Likely Benign: not specified; not provided 104,599,171(-) C/G
NM_001004482.1(OR13C5):c.243G>C (p.Thr81=)
SYNONYMOUS
rs79797302 Likely Benign: not provided 104,599,168(-) T/C
NM_001004482.1(OR13C5):c.246A>G (p.Leu82=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR13C5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR13C5 Gene

Variant ID Type Subtype PubMed ID
dgv150n17 CNV loss 16327808
dgv7696n100 CNV gain 25217958
esv22412 CNV loss 19812545
esv2421682 OTHER complex 20811451
esv2546770 CNV deletion 19546169
esv2676803 CNV deletion 23128226
esv2759707 CNV gain+loss 17122850
esv2761260 CNV gain+loss 21179565
esv3891705 CNV loss 25118596
esv3891706 CNV gain 25118596
nsv436624 CNV deletion 17901297
nsv471313 CNV loss 18288195
nsv517609 CNV gain+loss 19592680
nsv825025 CNV loss 20364138
nsv831677 CNV gain 17160897
nsv8556 CNV loss 18304495
nsv972439 CNV duplication 23825009

Variation tolerance for OR13C5 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.94; 99.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR13C5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR13C5
Leiden Open Variation Database (LOVD)
OR13C5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR13C5 Gene

Disorders for OR13C5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR13C5 Gene - From: COP

Disorder Aliases PubMed IDs
developmental and epileptic encephalopathy 4
  • dee4
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR13C5

genes like me logo Genes that share disorders with OR13C5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR13C5 Gene

Publications for OR13C5 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR13C5 Gene

Sources for OR13C5 Gene