Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR13C4 Gene

Aliases for OR13C4 Gene

  • Olfactory Receptor Family 13 Subfamily C Member 4 2 3 5
  • Olfactory Receptor OR9-7 3 4
  • Olfactory Receptor 13C4 3 4
  • Olfactory Receptor, Family 13, Subfamily C, Member 4 2
  • Olfactory Receptor, Family 2, Subfamily K, Member 1 3
  • HSHTPCRX17 3
  • HTPCRX17 3
  • OR13C4 5
  • OR2K1 3
  • OR37F 3
  • OR9-7 3

External Ids for OR13C4 Gene

Previous GeneCards Identifiers for OR13C4 Gene

  • GC09U990154
  • GC09M102669
  • GC09M104368
  • GC09M106329
  • GC09M107288

Summaries for OR13C4 Gene

Entrez Gene Summary for OR13C4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR13C4 Gene

OR13C4 (Olfactory Receptor Family 13 Subfamily C Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C3.

UniProtKB/Swiss-Prot Summary for OR13C4 Gene

Gene Wiki entry for OR13C4 Gene

Additional gene information for OR13C4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR13C4 Gene

Genomics for OR13C4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR13C4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J104532 Enhancer 0.2 Ensembl 0.4 -5.4 -5392 0.4 NIPSNAP3A OR13C3 OR13C4 ENSG00000283001 RF00017-7780
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR13C4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR13C4

Top Transcription factor binding sites by QIAGEN in the OR13C4 gene promoter:
  • C/EBPalpha
  • Cdc5
  • E47
  • GATA-2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Tal-1

Genomic Locations for OR13C4 Gene

Genomic Locations for OR13C4 Gene
chr9:104,526,253-104,527,209
(GRCh38/hg38)
Size:
957 bases
Orientation:
Minus strand
chr9:107,288,534-107,289,490
(GRCh37/hg19)
Size:
957 bases
Orientation:
Minus strand

Genomic View for OR13C4 Gene

Genes around OR13C4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR13C4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR13C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR13C4 Gene

Proteins for OR13C4 Gene

  • Protein details for OR13C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGS5-O13C4_HUMAN
    Recommended name:
    Olfactory receptor 13C4
    Protein Accession:
    Q8NGS5
    Secondary Accessions:
    • Q6IF51
    • Q96R41

    Protein attributes for OR13C4 Gene

    Size:
    318 amino acids
    Molecular mass:
    35576 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR13C4 Gene

Post-translational modifications for OR13C4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR13C4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR13C4 Gene

Domains & Families for OR13C4 Gene

Gene Families for OR13C4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR13C4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR13C4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR9-7 (O13C4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGS5

UniProtKB/Swiss-Prot:

O13C4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR13C4: view

Function for OR13C4 Gene

Molecular function for OR13C4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR13C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR13C4: view

Phenotypes for OR13C4 Gene

genes like me logo Genes that share phenotypes with OR13C4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13C4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR13C4 Gene

Localization for OR13C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR13C4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR13C4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR13C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR13C4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR13C4 Gene

Pathways & Interactions for OR13C4 Gene

genes like me logo Genes that share pathways with OR13C4: view

Pathways by source for OR13C4 Gene

Interacting Proteins for OR13C4 Gene

Gene Ontology (GO) - Biological Process for OR13C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR13C4: view

No data available for SIGNOR curated interactions for OR13C4 Gene

Drugs & Compounds for OR13C4 Gene

No Compound Related Data Available

Transcripts for OR13C4 Gene

mRNA/cDNA for OR13C4 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13C4

Alternative Splicing Database (ASD) splice patterns (SP) for OR13C4 Gene

No ASD Table

Relevant External Links for OR13C4 Gene

GeneLoc Exon Structure for
OR13C4

Expression for OR13C4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR13C4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR13C4

SOURCE GeneReport for Unigene cluster for OR13C4 Gene:

Hs.553601
genes like me logo Genes that share expression patterns with OR13C4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR13C4 Gene

Orthologs for OR13C4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR13C4 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia OR13C4 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr845 30
  • 80.49 (n)
Oppossum
(Monodelphis domestica)
Mammalia OPOR63 31
  • 79 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 65 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Or13b1-ps 46 Olfr274-ps1
  • chr4:52,842,219-52,843,137
Species where no ortholog for OR13C4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR13C4 Gene

ENSEMBL:
Gene Tree for OR13C4 (if available)
TreeFam:
Gene Tree for OR13C4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR13C4: view image

Paralogs for OR13C4 Gene

(450) SIMAP similar genes for OR13C4 Gene using alignment to 1 proteins:

  • O13C4_HUMAN
genes like me logo Genes that share paralogs with OR13C4: view

Variants for OR13C4 Gene

Additional dbSNP identifiers (rs#s) for OR13C4 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR13C4 Gene

Variant ID Type Subtype PubMed ID
esv3891705 CNV loss 25118596
esv3891706 CNV gain 25118596
nsv466462 CNV loss 19166990
nsv615067 CNV loss 21841781
nsv615068 CNV loss 21841781
nsv831677 CNV gain 17160897

Variation tolerance for OR13C4 Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR13C4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR13C4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR13C4 Gene

Disorders for OR13C4 Gene

Additional Disease Information for OR13C4

No disorders were found for OR13C4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR13C4 Gene

Publications for OR13C4 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson SA … Youle RJ (Nature 2013) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR13C4 Gene

Sources for OR13C4 Gene