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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR13C3 (Olfactory Receptor Family 13 Subfamily C Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C4.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09J104906 | Enhancer | 1.1 | FANTOM5 ENCODE dbSUPER | 6.5 | -370.2 | -370183 | 2 | REST SP1 FOXA2 ATF3 YY1 ZBTB33 RBM22 JUND NR2F2 MAFK | lnc-NIPSNAP3B-4 ABCA1 OR13C3 SLC44A1 ENSG00000226334 NIPSNAP3B | |
GH09J104586 | Enhancer | 0.2 | ENCODE | 10.6 | -49.8 | -49839 | 0.2 | NIPSNAP3A OR13C3 OR13D1 OR13D2P OR13C5 piR-31199-381 OR13C8 | ||
GH09J104971 | Enhancer | 0.2 | FANTOM5 | 6.2 | -435.1 | -435075 | 0 | OR13C3 SLC44A1 OR13C8 lnc-ABCA1-9 lnc-NIPSNAP3B-5 CT70 ABCA1 MN298678-148 | ||
GH09J104532 | Enhancer | 0.2 | Ensembl | 0.7 | +4.3 | 4255 | 0.4 | NIPSNAP3A OR13C3 OR13C4 ENSG00000283001 RF00017-7780 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC473002 30 |
|
||
OR13C3 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | OR13C3 30 |
|
||
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | OR13C3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Or13c3 46 Olfr273 30 17 31 |
|
OneToOne |
|
Rat (Rattus norvegicus) |
Mammalia | LOC100912327 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | OPOR63 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10512330 | - | p.Lys293Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3891705 | CNV | loss | 25118596 |
esv3891706 | CNV | gain | 25118596 |
nsv466462 | CNV | loss | 19166990 |
nsv615068 | CNV | loss | 21841781 |
nsv831677 | CNV | gain | 17160897 |
No disorders were found for OR13C3 Gene.