Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR13C3 Gene

Aliases for OR13C3 Gene

  • Olfactory Receptor Family 13 Subfamily C Member 3 2 3 5
  • Olfactory Receptor OR9-8 3 4
  • Olfactory Receptor 13C3 3 4
  • Olfactory Receptor, Family 13, Subfamily C, Member 3 2
  • OR13C3 5
  • OR37G 3
  • OR9-8 3

External Ids for OR13C3 Gene

Previous GeneCards Identifiers for OR13C3 Gene

  • GC09U990156
  • GC09M102678
  • GC09M104377
  • GC09M106337
  • GC09M107298

Summaries for OR13C3 Gene

Entrez Gene Summary for OR13C3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR13C3 Gene

OR13C3 (Olfactory Receptor Family 13 Subfamily C Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C4.

UniProtKB/Swiss-Prot Summary for OR13C3 Gene

Gene Wiki entry for OR13C3 Gene

Additional gene information for OR13C3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR13C3 Gene

Genomics for OR13C3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR13C3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J104906 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 6.5 -370.2 -370183 2 REST SP1 FOXA2 ATF3 YY1 ZBTB33 RBM22 JUND NR2F2 MAFK lnc-NIPSNAP3B-4 ABCA1 OR13C3 SLC44A1 ENSG00000226334 NIPSNAP3B
GH09J104586 Enhancer 0.2 ENCODE 10.6 -49.8 -49839 0.2 NIPSNAP3A OR13C3 OR13D1 OR13D2P OR13C5 piR-31199-381 OR13C8
GH09J104971 Enhancer 0.2 FANTOM5 6.2 -435.1 -435075 0 OR13C3 SLC44A1 OR13C8 lnc-ABCA1-9 lnc-NIPSNAP3B-5 CT70 ABCA1 MN298678-148
GH09J104532 Enhancer 0.2 Ensembl 0.7 +4.3 4255 0.4 NIPSNAP3A OR13C3 OR13C4 ENSG00000283001 RF00017-7780
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR13C3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR13C3

Top Transcription factor binding sites by QIAGEN in the OR13C3 gene promoter:
  • C/EBPalpha
  • E47
  • GATA-2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Nkx6-1
  • Tal-1

Genomic Locations for OR13C3 Gene

Genomic Locations for OR13C3 Gene
chr9:104,535,749-104,536,856
(GRCh38/hg38)
Size:
1,108 bases
Orientation:
Minus strand
chr9:107,298,030-107,299,137
(GRCh37/hg19)
Size:
1,108 bases
Orientation:
Minus strand

Genomic View for OR13C3 Gene

Genes around OR13C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR13C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR13C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR13C3 Gene

Proteins for OR13C3 Gene

  • Protein details for OR13C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGS6-O13C3_HUMAN
    Recommended name:
    Olfactory receptor 13C3
    Protein Accession:
    Q8NGS6
    Secondary Accessions:
    • Q5VVG1
    • Q6IF52

    Protein attributes for OR13C3 Gene

    Size:
    347 amino acids
    Molecular mass:
    38729 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05934.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR13C3 Gene

Post-translational modifications for OR13C3 Gene

  • Glycosylation at Asn35
  • Modification sites at PhosphoSitePlus

Other Protein References for OR13C3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR13C3 Gene

Domains & Families for OR13C3 Gene

Gene Families for OR13C3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR13C3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR13C3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR9-8 (O13C3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGS6

UniProtKB/Swiss-Prot:

O13C3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR13C3: view

Function for OR13C3 Gene

Molecular function for OR13C3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR13C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR13C3: view
genes like me logo Genes that share phenotypes with OR13C3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13C3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR13C3 Gene

Localization for OR13C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR13C3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR13C3 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for OR13C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR13C3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR13C3 Gene

Pathways & Interactions for OR13C3 Gene

genes like me logo Genes that share pathways with OR13C3: view

Pathways by source for OR13C3 Gene

Interacting Proteins for OR13C3 Gene

Gene Ontology (GO) - Biological Process for OR13C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR13C3: view

No data available for SIGNOR curated interactions for OR13C3 Gene

Drugs & Compounds for OR13C3 Gene

No Compound Related Data Available

Transcripts for OR13C3 Gene

mRNA/cDNA for OR13C3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR13C3

Alternative Splicing Database (ASD) splice patterns (SP) for OR13C3 Gene

No ASD Table

Relevant External Links for OR13C3 Gene

GeneLoc Exon Structure for
OR13C3

Expression for OR13C3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR13C3 Gene

mRNA differential expression in normal tissues according to GTEx for OR13C3 Gene

This gene is overexpressed in Testis (x28.6), Liver (x7.7), Bladder (x4.4), Brain - Cortex (x4.2), and Cervix - Ectocervix (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR13C3

SOURCE GeneReport for Unigene cluster for OR13C3 Gene:

Hs.553600
genes like me logo Genes that share expression patterns with OR13C3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR13C3 Gene

Orthologs for OR13C3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR13C3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC473002 30
  • 98.56 (n)
OR13C3 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR13C3 30
  • 88.33 (n)
-- 31
  • 72 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia OR13C3 30 31
  • 87.17 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or13c3 46 Olfr273 30 17 31
  • 85.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100912327 30
  • 84.8 (n)
Oppossum
(Monodelphis domestica)
Mammalia OPOR63 31
  • 83 (a)
OneToMany
Species where no ortholog for OR13C3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR13C3 Gene

ENSEMBL:
Gene Tree for OR13C3 (if available)
TreeFam:
Gene Tree for OR13C3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR13C3: view image

Paralogs for OR13C3 Gene

(453) SIMAP similar genes for OR13C3 Gene using alignment to 1 proteins:

  • O13C3_HUMAN
genes like me logo Genes that share paralogs with OR13C3: view

Variants for OR13C3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR13C3 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs10512330 - p.Lys293Thr

Additional dbSNP identifiers (rs#s) for OR13C3 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR13C3 Gene

Variant ID Type Subtype PubMed ID
esv3891705 CNV loss 25118596
esv3891706 CNV gain 25118596
nsv466462 CNV loss 19166990
nsv615068 CNV loss 21841781
nsv831677 CNV gain 17160897

Variation tolerance for OR13C3 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.31; 76.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR13C3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR13C3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR13C3 Gene

Disorders for OR13C3 Gene

No disorders were found for OR13C3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR13C3 Gene

Publications for OR13C3 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human. (PMID: 12906860) Hoppe R … Strotmann J (Genomics 2003) 3

Products for OR13C3 Gene

Sources for OR13C3 Gene