Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR12D1 Gene

Aliases for OR12D1 Gene

  • Olfactory Receptor Family 12 Subfamily D Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 12, Subfamily D, Member 1 Pseudogene 2 3
  • Olfactory Receptor 12D1 Pseudogene 3 4
  • Olfactory Receptor 12D1 3 4
  • Hs6M1-19 2 3
  • OR12D1P 3 4
  • Olfactory Receptor, Family 12, Subfamily D, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 12, Subfamily D, Member 1 2
  • OR12D1 5

External Ids for OR12D1 Gene

Previous HGNC Symbols for OR12D1 Gene

  • OR12D1P

Previous GeneCards Identifiers for OR12D1 Gene

  • GC06P029492
  • GC06P029388
  • GC06P029417
  • GC06P049244

Summaries for OR12D1 Gene

Entrez Gene Summary for OR12D1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR12D1 Gene

OR12D1 (Olfactory Receptor Family 12 Subfamily D Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Olfactory transduction. An important paralog of this gene is OR12D2.

UniProtKB/Swiss-Prot Summary for OR12D1 Gene

Additional gene information for OR12D1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR12D1 Gene

Genomics for OR12D1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR12D1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J029414 Enhancer 0.4 Ensembl 250.7 0.0 -27 0.2 CTCF SCRT1 RAD21 SCRT2 OR12D1 OR10C1 OR5V1 OR11A1 OR2H1 OR12D2 LOC105379641
GH06J029424 Enhancer 0.2 Ensembl 0.4 +9.5 9473 0.4 OR2H2 lnc-OR12D3-3 NONHSAG045539.2 HSALNG0049054 OR12D1 OR10C1 LOC105379641 OR5V1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR12D1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR12D1

Genomic Locations for OR12D1 Gene

Latest Assembly
chr6:29,414,928-29,418,905
(GRCh38/hg38)
Size:
3,978 bases
Orientation:
Plus strand

Previous Assembly
chr6:29,384,842-29,386,173
(GRCh37/hg19 by Entrez Gene)
Size:
1,332 bases
Orientation:
Plus strand

chr6:29,385,057-29,386,003
(GRCh37/hg19 by Ensembl)
Size:
947 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr6(ALT_REF_LOCI_2):903,516-904,847 (+)
  • chr6(ALT_REF_LOCI_3):682,579-683,926 (+)
  • chr6(ALT_REF_LOCI_4):682,203-683,534 (+)
  • chr6(ALT_REF_LOCI_5):682,433-683,764 (+)
  • chr6(ALT_REF_LOCI_6):682,537-683,868 (+)
  • chr6(ALT_REF_LOCI_7):726,078-727,409 (+)

Genomic View for OR12D1 Gene

Genes around OR12D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR12D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR12D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR12D1 Gene

  • Protein details for OR12D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN82-O12D1_HUMAN
    Recommended name:
    Olfactory receptor 12D1
    Protein Accession:
    P0DN82

    Protein attributes for OR12D1 Gene

    Size:
    309 amino acids
    Molecular mass:
    35330 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR12D1 Gene

Post-translational modifications for OR12D1 Gene

  • Glycosylation at Asn3

Other Protein References for OR12D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR12D1 Gene

Domains & Families for OR12D1 Gene

Gene Families for OR12D1 Gene

Protein Domains for OR12D1 Gene

Graphical View of Domain Structure for InterPro Entry

P0DN82

UniProtKB/Swiss-Prot:

O12D1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR12D1: view

No data available for Suggested Antigen Peptide Sequences for OR12D1 Gene

Function for OR12D1 Gene

Molecular function for OR12D1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR12D1 Gene

Gene Ontology (GO) - Molecular Function for OR12D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR12D1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR12D1 Gene

Localization for OR12D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR12D1 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR12D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with OR12D1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR12D1 Gene

Pathways & Interactions for OR12D1 Gene

PathCards logo

SuperPathways for OR12D1 Gene

SuperPathway Contained pathways
1 Olfactory transduction
genes like me logo Genes that share pathways with OR12D1: view

Pathways by source for OR12D1 Gene

1 KEGG pathway for OR12D1 Gene

Interacting Proteins for OR12D1 Gene

Gene Ontology (GO) - Biological Process for OR12D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA 21873635
genes like me logo Genes that share ontologies with OR12D1: view

No data available for SIGNOR curated interactions for OR12D1 Gene

Drugs & Compounds for OR12D1 Gene

No Compound Related Data Available

Transcripts for OR12D1 Gene

mRNA/cDNA for OR12D1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR12D1 Gene

No ASD Table

Relevant External Links for OR12D1 Gene

GeneLoc Exon Structure for
OR12D1

Expression for OR12D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR12D1 Gene

genes like me logo Genes that share expression patterns with OR12D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR12D1 Gene

Orthologs for OR12D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR12D1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 30
  • 58 (a)
OneToMany
OR12D2 30
  • 58 (a)
OneToMany
-- 30
  • 57 (a)
OneToMany
-- 30
  • 57 (a)
OneToMany
-- 30
  • 57 (a)
OneToMany
-- 30
  • 57 (a)
OneToMany
-- 30
  • 57 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Olfr102 30
  • 55 (a)
OneToMany
Olfr101 30
  • 54 (a)
OneToMany
Olfr103 30
  • 53 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 51 (a)
ManyToMany
-- 30
  • 51 (a)
ManyToMany
-- 30
  • 51 (a)
ManyToMany
-- 30
  • 50 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 48 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 45 (a)
OneToMany
Species where no ortholog for OR12D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR12D1 Gene

ENSEMBL:
Gene Tree for OR12D1 (if available)
TreeFam:
Gene Tree for OR12D1 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR12D1

Paralogs for OR12D1 Gene

genes like me logo Genes that share paralogs with OR12D1: view

Variants for OR12D1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR12D1 Gene

O12D1_HUMAN-P0DN82
Segregating pseudogene, locus showing both intact and pseudogene forms in the population. A deletion of 16 nucleotides at position Ser-186 in the gene coding for this protein is responsible for functional diversity, producing a pseudogene.

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR12D1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for OR12D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR12D1
Leiden Open Variation Database (LOVD)
OR12D1

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR12D1 Gene

Disorders for OR12D1 Gene

Additional Disease Information for OR12D1

No disorders were found for OR12D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR12D1 Gene

Publications for OR12D1 Gene

  1. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4

Products for OR12D1 Gene

Sources for OR12D1 Gene