Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR11L1 Gene

Aliases for OR11L1 Gene

  • Olfactory Receptor Family 11 Subfamily L Member 1 2 3 5
  • Olfactory Receptor 11L1 3 4
  • Olfactory Receptor, Family 11, Subfamily L, Member 1 2
  • Olfactory Receptor OR1-50 3
  • OR11L1 5

External Ids for OR11L1 Gene

Previous GeneCards Identifiers for OR11L1 Gene

  • GC01U990419
  • GC01M244305
  • GC01M246070
  • GC01M248004

Summaries for OR11L1 Gene

Entrez Gene Summary for OR11L1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11L1 Gene

OR11L1 (Olfactory Receptor Family 11 Subfamily L Member 1) is a Protein Coding gene. Diseases associated with OR11L1 include Phacogenic Glaucoma. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR8H1.

UniProtKB/Swiss-Prot Summary for OR11L1 Gene

Gene Wiki entry for OR11L1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR11L1 Gene

Genomics for OR11L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR11L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247854 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.4 -13.3 -13335 2.1 NCOR1 ZNF592 NFIC TBP ARNT NBN TAL1 ZNF316 NFE2 MYNN TRIM58 OR2T8 OR13G1 OR2W3 OR11L1
GH01J247844 Enhancer 0.5 Ensembl 0.7 -3.2 -3205 0.6 MAFG TCF12 RNF2 PKNOX1 HMBOX1 EMSY OR14A16 OR2W3 OR11L1 TRIM58
GH01J247852 Enhancer 0.5 Ensembl 0.4 -10.8 -10805 1.8 MAFF ZNF316 NFE2 MAFK SPI1 MAFG HMBOX1 EMSY TRIM58 OR2AJ1 OR2T8 OR13G1 OR11L1
GH01J247823 Enhancer 0.3 Ensembl 0.4 +17.7 17695 0.4 ATF2 OR14A16 HSD17B7P1 OR11L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR11L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR11L1

Top Transcription factor binding sites by QIAGEN in the OR11L1 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • GATA-2
  • GR
  • GR-alpha

Genomic Locations for OR11L1 Gene

Latest Assembly
chr1:247,840,928-247,841,896
(GRCh38/hg38)
Size:
969 bases
Orientation:
Minus strand

Previous Assembly
chr1:248,004,230-248,005,198
(GRCh37/hg19 by Entrez Gene)
Size:
969 bases
Orientation:
Minus strand

chr1:248,004,199-248,005,254
(GRCh37/hg19 by Ensembl)
Size:
1,056 bases
Orientation:
Minus strand

Genomic View for OR11L1 Gene

Genes around OR11L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11L1 Gene

Proteins for OR11L1 Gene

  • Protein details for OR11L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGX0-O11L1_HUMAN
    Recommended name:
    Olfactory receptor 11L1
    Protein Accession:
    Q8NGX0
    Secondary Accessions:
    • B9EIN8

    Protein attributes for OR11L1 Gene

    Size:
    322 amino acids
    Molecular mass:
    36763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11L1 Gene

Post-translational modifications for OR11L1 Gene

  • Glycosylation at Asn5

Other Protein References for OR11L1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11L1 Gene

Domains & Families for OR11L1 Gene

Gene Families for OR11L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR11L1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR11L1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 11, subfamily L, member 1 (B9EIN8_HUMAN)
  • Olfactory receptor 11L1 (O11L1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGX0

UniProtKB/Swiss-Prot:

O11L1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11L1: view

Function for OR11L1 Gene

Molecular function for OR11L1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR11L1 Gene

Gene Ontology (GO) - Molecular Function for OR11L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR11L1: view
genes like me logo Genes that share phenotypes with OR11L1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR11L1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11L1 Gene

Localization for OR11L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11L1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11L1 gene
Compartment Confidence
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for OR11L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with OR11L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR11L1 Gene

Pathways & Interactions for OR11L1 Gene

genes like me logo Genes that share pathways with OR11L1: view

Pathways by source for OR11L1 Gene

Interacting Proteins for OR11L1 Gene

Gene Ontology (GO) - Biological Process for OR11L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0008150 biological_process ND --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR11L1: view

No data available for SIGNOR curated interactions for OR11L1 Gene

Drugs & Compounds for OR11L1 Gene

No Compound Related Data Available

Transcripts for OR11L1 Gene

mRNA/cDNA for OR11L1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR11L1

Alternative Splicing Database (ASD) splice patterns (SP) for OR11L1 Gene

No ASD Table

Relevant External Links for OR11L1 Gene

GeneLoc Exon Structure for
OR11L1

Expression for OR11L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR11L1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR11L1

SOURCE GeneReport for Unigene cluster for OR11L1 Gene:

Hs.553781
genes like me logo Genes that share expression patterns with OR11L1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11L1 Gene

Orthologs for OR11L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR11L1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia OR11L1 29 30
  • 82.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or11l3 45 Olfr323 29 16 30
  • 78.46 (n)
OneToOne
Or5bw2 45 Olfr1350
  • chr7:6,569,993-6,570,916
Rat
(Rattus norvegicus)
Mammalia Olr1432 29
  • 77.5 (n)
Dog
(Canis familiaris)
Mammalia OR11L1 30
  • 77 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR11L1 30
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OR11L1 30
  • 62 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488665 29
  • 58.09 (n)
Zebrafish
(Danio rerio)
Actinopterygii or103-5 30
  • 26 (a)
ManyToMany
Species where no ortholog for OR11L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OR11L1 Gene

ENSEMBL:
Gene Tree for OR11L1 (if available)
TreeFam:
Gene Tree for OR11L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR11L1: view image
Alliance of Genome Resources:
Additional Orthologs for OR11L1

Paralogs for OR11L1 Gene

(457) SIMAP similar genes for OR11L1 Gene using alignment to 2 proteins:

  • O11L1_HUMAN
  • B9EIN8_HUMAN
genes like me logo Genes that share paralogs with OR11L1: view

Variants for OR11L1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR11L1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs10888255 -- p.Arg171Pro
rs10888256 -- p.Ala142Thr
rs10888257 -- p.Gly108Ser
rs540891010 -- p.Phe117Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR11L1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR11L1 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3589522 CNV gain 21293372
nsv1008024 CNV gain 25217958
nsv1010087 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549601 CNV loss 21841781
nsv549602 CNV loss 21841781

Variation tolerance for OR11L1 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR11L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR11L1
Leiden Open Variation Database (LOVD)
OR11L1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11L1 Gene

Disorders for OR11L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR11L1 Gene - From: COP

Disorder Aliases PubMed IDs
phacogenic glaucoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR11L1

genes like me logo Genes that share disorders with OR11L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR11L1 Gene

Publications for OR11L1 Gene

  1. Human olfactory receptor responses to odorants. (PMID: 25977809) Mainland JD … Matsunami H (Scientific data 2015) 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales PA … Knepper MA (Journal of the American Society of Nephrology : JASN 2009) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3

Products for OR11L1 Gene

Sources for OR11L1 Gene