Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR11H7 Gene

Aliases for OR11H7 Gene

  • Olfactory Receptor Family 11 Subfamily H Member 7 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 11, Subfamily H, Member 7 Pseudogene 2 3
  • Olfactory Receptor OR14-32 3 4
  • Olfactory Receptor 11H7 3 4
  • OR11H7P 3 4
  • Olfactory Receptor, Family 11, Subfamily H, Member 7 (Gene/Pseudogene) 2
  • Seven Transmembrane Helix Receptor 3
  • OR11H7 5

External Ids for OR11H7 Gene

Previous HGNC Symbols for OR11H7 Gene

  • OR11H7P

Previous GeneCards Identifiers for OR11H7 Gene

  • GC14P019768
  • GC14P020697
  • GC14P000819
  • GC14P020230
  • GC14P020234
  • GC14P020239
  • GC14P020250

Summaries for OR11H7 Gene

Entrez Gene Summary for OR11H7 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR11H7 Gene

OR11H7 (Olfactory Receptor Family 11 Subfamily H Member 7 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H4.

UniProtKB/Swiss-Prot Summary for OR11H7 Gene

Additional gene information for OR11H7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR11H7 Gene

Genomics for OR11H7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR11H7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J021092 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.6 +872.3 872335 18.5 BCLAF1 SP1 ZNF207 ZNF654 MYC NCOR1 ZNF600 IKZF1 SIX5 SSRP1 HSALNG0099864 ZNF219 METTL3 SUPT16H CHD8 METTL17 ENSG00000258515 OSGEP PIP4P1 PNP
GH14J020798 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 5.8 +571.9 571925 5.6 IKZF1 NCOR1 ZNF592 NFIC ARNT TAF9B TAL1 ZNF316 TEAD3 NFE2 EGILA LOC107984671 RNASE1 OR11H7 lnc-RNASE6-2 LOC105370397 RNASE6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR11H7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR11H7

Genomic Locations for OR11H7 Gene

Latest Assembly
chr14:20,228,981-20,230,749
(GRCh38/hg38)
Size:
1,769 bases
Orientation:
Plus strand

Previous Assembly
chr14:20,697,140-20,698,908
(GRCh37/hg19 by Entrez Gene)
Size:
1,769 bases
Orientation:
Plus strand

chr14:20,697,561-20,698,500
(GRCh37/hg19 by Ensembl)
Size:
940 bases
Orientation:
Plus strand

Genomic View for OR11H7 Gene

Genes around OR11H7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11H7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11H7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H7 Gene

Proteins for OR11H7 Gene

  • Protein details for OR11H7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC8-O11H7_HUMAN
    Recommended name:
    Olfactory receptor 11H7
    Protein Accession:
    Q8NGC8

    Protein attributes for OR11H7 Gene

    Size:
    314 amino acids
    Molecular mass:
    35499 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H7 Gene

Post-translational modifications for OR11H7 Gene

  • Glycosylation at Asn2

Other Protein References for OR11H7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR11H7 Gene

Domains & Families for OR11H7 Gene

Gene Families for OR11H7 Gene

Protein Domains for OR11H7 Gene

Suggested Antigen Peptide Sequences for OR11H7 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR14-32 (O11H7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGC8

UniProtKB/Swiss-Prot:

O11H7_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11H7: view

Function for OR11H7 Gene

Molecular function for OR11H7 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor. Activated by isovaleric acid.

Phenotypes From GWAS Catalog for OR11H7 Gene

Gene Ontology (GO) - Molecular Function for OR11H7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR11H7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11H7 Gene

Localization for OR11H7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H7 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR11H7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0030425 dendrite IBA 21873635
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with OR11H7: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR11H7 Gene

Pathways & Interactions for OR11H7 Gene

genes like me logo Genes that share pathways with OR11H7: view

Pathways by source for OR11H7 Gene

Interacting Proteins for OR11H7 Gene

Gene Ontology (GO) - Biological Process for OR11H7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
GO:0098664 G protein-coupled serotonin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with OR11H7: view

No data available for SIGNOR curated interactions for OR11H7 Gene

Drugs & Compounds for OR11H7 Gene

No Compound Related Data Available

Transcripts for OR11H7 Gene

mRNA/cDNA for OR11H7 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H7 Gene

No ASD Table

Relevant External Links for OR11H7 Gene

GeneLoc Exon Structure for
OR11H7

Expression for OR11H7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR11H7 Gene

mRNA differential expression in normal tissues according to GTEx for OR11H7 Gene

This gene is overexpressed in Testis (x6.0).
genes like me logo Genes that share expression patterns with OR11H7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11H7 Gene

Orthologs for OR11H7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11H7 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia OR11H7 30
  • 83 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or11h7 45 Olfr746 30
  • 80 (a)
OneToMany
Or11h23 45 Olfr748 30
  • 80 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 61 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 57 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 56 (a)
OneToMany
Species where no ortholog for OR11H7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR11H7 Gene

ENSEMBL:
Gene Tree for OR11H7 (if available)
TreeFam:
Gene Tree for OR11H7 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR11H7

Paralogs for OR11H7 Gene

(456) SIMAP similar genes for OR11H7 Gene using alignment to 1 proteins:

  • O11H7_HUMAN
genes like me logo Genes that share paralogs with OR11H7: view

Variants for OR11H7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR11H7 Gene

O11H7_HUMAN-Q8NGC8
A stop codon in the gene coding for this protein at position Gln-227 is responsible for functional diversity thus producing a pseudogene. Hypersensitivity towards isovaleric acid is seen predominantly in individuals who carry at least one copy of the intact allele.

Additional Variant Information for OR11H7 Gene

Human Gene Mutation Database (HGMD)
OR11H7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR11H7
Leiden Open Variation Database (LOVD)
OR11H7

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR11H7 Gene

Disorders for OR11H7 Gene

Additional Disease Information for OR11H7

No disorders were found for OR11H7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11H7 Gene

Publications for OR11H7 Gene

  1. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I … Lancet D (PLoS biology 2007) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4
  4. Different noses for different people. (PMID: 12730696) Menashe I … Gilad Y (Nature genetics 2003) 3 4
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4

Products for OR11H7 Gene

Sources for OR11H7 Gene