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Aliases for OR11H6 Gene

Aliases for OR11H6 Gene

  • Olfactory Receptor Family 11 Subfamily H Member 6 2 3 5
  • Olfactory Receptor OR14-35 3 4
  • Olfactory Receptor, Family 11, Subfamily H, Member 6 2
  • Olfactory Receptor 11H6 3

External Ids for OR11H6 Gene

Previous GeneCards Identifiers for OR11H6 Gene

  • GC14U990444
  • GC14P018682
  • GC14P019761
  • GC14P020691

Summaries for OR11H6 Gene

Entrez Gene Summary for OR11H6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11H6 Gene

OR11H6 (Olfactory Receptor Family 11 Subfamily H Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H4.

UniProtKB/Swiss-Prot for OR11H6 Gene

  • Odorant receptor.

Gene Wiki entry for OR11H6 Gene

Additional gene information for OR11H6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11H6 Gene

Genomics for OR11H6 Gene

GeneHancer (GH) Regulatory Elements for OR11H6 Gene

Promoters and enhancers for OR11H6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020591 Enhancer 0.3 FANTOM5 14.7 +368.2 368161 0.1 IKZF1 RNASE12 OR4K17 OR6S1 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
GH14J020071 Enhancer 0.3 FANTOM5 6.2 -151.9 -151942 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR11H6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR11H6 gene promoter:
  • HSF1short
  • HSF1 (long)
  • CUTL1
  • AML1a
  • Ik-1
  • E47
  • Tal-1
  • LCR-F1
  • PPAR-gamma2

Genomic Locations for OR11H6 Gene

Genomic Locations for OR11H6 Gene
993 bases
Plus strand
1,174 bases
Plus strand

Genomic View for OR11H6 Gene

Genes around OR11H6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11H6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11H6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H6 Gene

Proteins for OR11H6 Gene

  • Protein details for OR11H6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 11H6
    Protein Accession:
    Secondary Accessions:
    • Q6IF08

    Protein attributes for OR11H6 Gene

    330 amino acids
    Molecular mass:
    36788 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H6 Gene

Post-translational modifications for OR11H6 Gene

Other Protein References for OR11H6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11H6 Gene

Domains & Families for OR11H6 Gene

Gene Families for OR11H6 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR11H6 Gene

Suggested Antigen Peptide Sequences for OR11H6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11H6: view

Function for OR11H6 Gene

Molecular function for OR11H6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR11H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11H6: view
genes like me logo Genes that share phenotypes with OR11H6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11H6 Gene

Localization for OR11H6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11H6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11H6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR11H6 Gene

Pathways & Interactions for OR11H6 Gene

genes like me logo Genes that share pathways with OR11H6: view

Pathways by source for OR11H6 Gene

Interacting Proteins for OR11H6 Gene

Gene Ontology (GO) - Biological Process for OR11H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11H6: view

No data available for SIGNOR curated interactions for OR11H6 Gene

Drugs & Compounds for OR11H6 Gene

No Compound Related Data Available

Transcripts for OR11H6 Gene

mRNA/cDNA for OR11H6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR11H6 Gene

Olfactory receptor, family 11, subfamily H, member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H6 Gene

No ASD Table

Relevant External Links for OR11H6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR11H6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR11H6 Gene

mRNA differential expression in normal tissues according to GTEx for OR11H6 Gene

This gene is overexpressed in Testis (x15.0), Esophagus - Gastroesophageal Junction (x4.3), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Frontal Cortex (BA9) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of OR11H6 Gene:


SOURCE GeneReport for Unigene cluster for OR11H6 Gene:

genes like me logo Genes that share expression patterns with OR11H6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11H6 Gene

Orthologs for OR11H6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR11H6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC740639 33
  • 99.19 (n)
OR11H6 34
  • 99 (a)
(Bos Taurus)
Mammalia LOC514151 33
  • 89.25 (n)
OR11H6 34
  • 88 (a)
(Canis familiaris)
Mammalia LOC482550 33
  • 88.18 (n)
OR11H6 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Olr1621 33
  • 84.51 (n)
(Mus musculus)
Mammalia Or11h6 51 Olfr745 16 34 33
  • 84.3 (n)
Or11j4 51 Olfr736
  • chr14:50,392,758-50,393,693
(Monodelphis domestica)
Mammalia OR11H6 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486213 33
  • 52.15 (n)
Species where no ortholog for OR11H6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11H6 Gene

Gene Tree for OR11H6 (if available)
Gene Tree for OR11H6 (if available)
Evolutionary constrained regions (ECRs) for OR11H6: view image

Paralogs for OR11H6 Gene

Paralogs for OR11H6 Gene

(450) SIMAP similar genes for OR11H6 Gene using alignment to 1 proteins:

  • O11H6_HUMAN
genes like me logo Genes that share paralogs with OR11H6: view

Variants for OR11H6 Gene

Sequence variations from dbSNP and Humsavar for OR11H6 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000770475 -- 20,221,910(+) A/G upstream_transcript_variant
rs1000956815 -- 20,221,800(+) G/A upstream_transcript_variant
rs1001389486 -- 20,221,902(+) T/A upstream_transcript_variant
rs1001674099 -- 20,222,849(+) G/C upstream_transcript_variant
rs1002359720 -- 20,223,111(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR11H6 Gene

Variant ID Type Subtype PubMed ID
dgv1797n100 CNV loss 25217958
dgv3532n54 CNV loss 21841781
esv2751268 CNV gain 17911159
esv3580929 CNV loss 25503493
esv3633679 CNV loss 21293372
esv3633681 CNV loss 21293372
nsv456144 CNV loss 19166990
nsv563844 CNV loss 21841781
nsv563845 CNV gain 21841781
nsv832739 CNV gain 17160897

Variation tolerance for OR11H6 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.97; 98.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR11H6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11H6 Gene

Disorders for OR11H6 Gene

Additional Disease Information for OR11H6

No disorders were found for OR11H6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11H6 Gene

Publications for OR11H6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58

Products for OR11H6 Gene

Sources for OR11H6 Gene

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