Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR11H4 Gene

Aliases for OR11H4 Gene

  • Olfactory Receptor Family 11 Subfamily H Member 4 2 3 5
  • Olfactory Receptor OR14-36 3 4
  • Olfactory Receptor 11H4 3 4
  • Olfactory Receptor, Family 11, Subfamily H, Member 4 2
  • OR14-36 3
  • OR11H4 5

External Ids for OR11H4 Gene

Previous GeneCards Identifiers for OR11H4 Gene

  • GC14U990446
  • GC14P018703
  • GC14P019780
  • GC14P020710
  • GC14P020242
  • GC14P020244

Summaries for OR11H4 Gene

Entrez Gene Summary for OR11H4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11H4 Gene

OR11H4 (Olfactory Receptor Family 11 Subfamily H Member 4) is a Protein Coding gene. Diseases associated with OR11H4 include Leber Plus Disease. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H6.

UniProtKB/Swiss-Prot Summary for OR11H4 Gene

Gene Wiki entry for OR11H4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR11H4 Gene

Genomics for OR11H4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR11H4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020591 Enhancer 0.4 FANTOM5 13.2 +352.6 352585 0.1 CBX2 IKZF1 RNASE12 OR4K17 OR6S1 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
GH14J020071 Enhancer 0.2 FANTOM5 6.4 -167.5 -167518 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
GH14J020305 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +66.4 66400 1.8 BCLAF1 ZNF207 NCOR1 MYC ZNF600 SSRP1 ZNF580 POLR2A ZNF10 ZBTB10 ENSG00000258459 TTC5 METTL17 TEP1 SNORA79B APEX1 ENSG00000258768 OR11H4
GH14J020262 Enhancer 1 Ensembl ENCODE 0.4 +23.6 23571 1.3 MYC IKZF1 NFIC BCL11A CEBPB BHLHE40 ZEB1 ZNF513 EP300 EBF1 HSALNG0099772 ENSG00000258515 METTL17 piR-48209-181 ENSG00000258768 OR11H4 TTC5
GH14J020295 Enhancer 0.9 Ensembl ENCODE 0.2 +55.4 55415 1.8 SP1 BCL11A TRIM22 IRF4 EBF1 CBFB BATF ELF1 IKZF1 BMI1 CCNB1IP1 ENSG00000258768 ENSG00000259001 TTC5 ENSG00000258459 OR11H4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR11H4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR11H4

Top Transcription factor binding sites by QIAGEN in the OR11H4 gene promoter:
  • AML1a
  • CUTL1
  • HSF1 (long)
  • HSF1short
  • Ik-1
  • POU3F1
  • Tal-1

Genomic Locations for OR11H4 Gene

Latest Assembly
chr14:20,239,286-20,244,349
(GRCh38/hg38)
Size:
5,064 bases
Orientation:
Plus strand

Previous Assembly
chr14:20,707,445-20,712,508
(GRCh37/hg19 by Entrez Gene)
Size:
5,064 bases
Orientation:
Plus strand

chr14:20,710,898-20,711,979
(GRCh37/hg19 by Ensembl)
Size:
1,082 bases
Orientation:
Plus strand

Genomic View for OR11H4 Gene

Genes around OR11H4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11H4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H4 Gene

Proteins for OR11H4 Gene

  • Protein details for OR11H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC9-O11H4_HUMAN
    Recommended name:
    Olfactory receptor 11H4
    Protein Accession:
    Q8NGC9
    Secondary Accessions:
    • B2RNQ4
    • Q6IF07

    Protein attributes for OR11H4 Gene

    Size:
    324 amino acids
    Molecular mass:
    36886 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H4 Gene

Post-translational modifications for OR11H4 Gene

  • Glycosylation at Asn12
  • Modification sites at PhosphoSitePlus

Other Protein References for OR11H4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11H4 Gene

Domains & Families for OR11H4 Gene

Gene Families for OR11H4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR11H4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR11H4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR14-36 (O11H4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGC9

UniProtKB/Swiss-Prot:

O11H4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11H4: view

Function for OR11H4 Gene

Molecular function for OR11H4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR11H4 Gene

Gene Ontology (GO) - Molecular Function for OR11H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR11H4: view
genes like me logo Genes that share phenotypes with OR11H4: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR11H4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11H4 Gene

Localization for OR11H4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11H4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with OR11H4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR11H4 Gene

Pathways & Interactions for OR11H4 Gene

genes like me logo Genes that share pathways with OR11H4: view

Pathways by source for OR11H4 Gene

Interacting Proteins for OR11H4 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000318997 Q8NGC9-O11H4_HUMAN for OR11H4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR11H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11H4: view

No data available for SIGNOR curated interactions for OR11H4 Gene

Drugs & Compounds for OR11H4 Gene

No Compound Related Data Available

Transcripts for OR11H4 Gene

mRNA/cDNA for OR11H4 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR11H4

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H4 Gene

No ASD Table

Relevant External Links for OR11H4 Gene

GeneLoc Exon Structure for
OR11H4

Expression for OR11H4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR11H4 Gene

mRNA differential expression in normal tissues according to GTEx for OR11H4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR11H4

SOURCE GeneReport for Unigene cluster for OR11H4 Gene:

Hs.553767
genes like me logo Genes that share expression patterns with OR11H4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11H4 Gene

Orthologs for OR11H4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11H4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC473319 29
  • 98.77 (n)
OR11H4 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR11H4 29 30
  • 88 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or11h4b 45 Olfr747 16 30
  • 87 (a)
OneToMany
Or11h4 45 Olfr749 29 16 30
  • 86.32 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia OR11H4 30
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1635 29
  • 83.95 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR11H4 30
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 60 (a)
OneToMany
Species where no ortholog for OR11H4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR11H4 Gene

ENSEMBL:
Gene Tree for OR11H4 (if available)
TreeFam:
Gene Tree for OR11H4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR11H4: view image
Alliance of Genome Resources:
Additional Orthologs for OR11H4

Paralogs for OR11H4 Gene

(453) SIMAP similar genes for OR11H4 Gene using alignment to 1 proteins:

  • O11H4_HUMAN

Pseudogenes.org Pseudogenes for OR11H4 Gene

genes like me logo Genes that share paralogs with OR11H4: view

Variants for OR11H4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR11H4 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs17277270 -- p.Thr301Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR11H4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR11H4 Gene

Variant ID Type Subtype PubMed ID
dgv1797n100 CNV loss 25217958
esv2751268 CNV gain 17911159
esv3633679 CNV loss 21293372
esv3633681 CNV loss 21293372
esv3633682 CNV loss 21293372
nsv563845 CNV gain 21841781
nsv832739 CNV gain 17160897

Variation tolerance for OR11H4 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR11H4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR11H4
Leiden Open Variation Database (LOVD)
OR11H4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11H4 Gene

Disorders for OR11H4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR11H4 Gene - From: COP

Disorder Aliases PubMed IDs
leber plus disease
  • lhon plus disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR11H4

genes like me logo Genes that share disorders with OR11H4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR11H4 Gene

Publications for OR11H4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. (PMID: 32126975) Barnes IHA … Frankish A (BMC genomics 2020) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR11H4 Gene

Sources for OR11H4 Gene