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Aliases for OR11H12 Gene

Aliases for OR11H12 Gene

  • Olfactory Receptor Family 11 Subfamily H Member 12 2 3 5
  • Olfactory Receptor, Family 11, Subfamily H, Member 12 2
  • Olfactory Receptor 11H12 3

External Ids for OR11H12 Gene

Previous GeneCards Identifiers for OR11H12 Gene

  • GC14P018436
  • GC14P019380

Summaries for OR11H12 Gene

Entrez Gene Summary for OR11H12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11H12 Gene

OR11H12 (Olfactory Receptor Family 11 Subfamily H Member 12) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H1.

UniProtKB/Swiss-Prot for OR11H12 Gene

  • Odorant receptor.

Additional gene information for OR11H12 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11H12 Gene

Genomics for OR11H12 Gene

GeneHancer (GH) Regulatory Elements for OR11H12 Gene

Top Transcription factor binding sites by QIAGEN in the OR11H12 gene promoter:
  • Lmo2
  • GATA-1
  • SEF-1 (1)
  • IRF-2
  • IRF-1
  • LCR-F1

Genomic Locations for OR11H12 Gene

Genomic Locations for OR11H12 Gene
1,085 bases
Plus strand
1,085 bases
Plus strand

Genomic View for OR11H12 Gene

Genes around OR11H12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11H12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11H12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H12 Gene

Proteins for OR11H12 Gene

  • Protein details for OR11H12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 11H12
    Protein Accession:

    Protein attributes for OR11H12 Gene

    326 amino acids
    Molecular mass:
    36530 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H12 Gene

Post-translational modifications for OR11H12 Gene

  • Glycosylation at Asn106, Asn18, and isoforms=13

Other Protein References for OR11H12 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11H12 Gene

Domains & Families for OR11H12 Gene

Gene Families for OR11H12 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR11H12 Gene

Suggested Antigen Peptide Sequences for OR11H12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11H12: view

Function for OR11H12 Gene

Molecular function for OR11H12 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR11H12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11H12: view

Phenotypes for OR11H12 Gene

genes like me logo Genes that share phenotypes with OR11H12: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11H12 Gene

Localization for OR11H12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11H12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11H12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11H12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR11H12 Gene

Pathways & Interactions for OR11H12 Gene

SuperPathways for OR11H12 Gene

SuperPathway Contained pathways
1 Olfactory Signaling Pathway
genes like me logo Genes that share pathways with OR11H12: view

Pathways by source for OR11H12 Gene

1 KEGG pathway for OR11H12 Gene

Interacting Proteins for OR11H12 Gene

Gene Ontology (GO) - Biological Process for OR11H12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11H12: view

No data available for SIGNOR curated interactions for OR11H12 Gene

Drugs & Compounds for OR11H12 Gene

No Compound Related Data Available

Transcripts for OR11H12 Gene

mRNA/cDNA for OR11H12 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR11H12 Gene

Olfactory receptor, family 11, subfamily H, member 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H12 Gene

No ASD Table

Relevant External Links for OR11H12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR11H12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR11H12 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR11H12 Gene:


SOURCE GeneReport for Unigene cluster for OR11H12 Gene:

genes like me logo Genes that share expression patterns with OR11H12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11H12 Gene

Orthologs for OR11H12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11H12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC740929 33
  • 98.57 (n)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia LOC102153096 33
  • 87.9 (n)
-- 34
  • 62 (a)
(Bos Taurus)
Mammalia LOC784332 33
  • 86.29 (n)
-- 34
  • 82 (a)
-- 34
  • 78 (a)
(Mus musculus)
Mammalia Olfr736 34
  • 63 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
Species where no ortholog for OR11H12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11H12 Gene

Gene Tree for OR11H12 (if available)
Gene Tree for OR11H12 (if available)

Paralogs for OR11H12 Gene

Paralogs for OR11H12 Gene

(454) SIMAP similar genes for OR11H12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR11H12: view

Variants for OR11H12 Gene

Sequence variations from dbSNP and Humsavar for OR11H12 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001382119 -- 18,599,441(+) A/T upstream_transcript_variant
rs1004544455 -- 18,599,160(+) C/T upstream_transcript_variant
rs1016044287 -- 18,599,172(+) A/G upstream_transcript_variant
rs1020611418 -- 18,599,832(+) T/G upstream_transcript_variant
rs1029107331 -- 18,601,974(+) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for OR11H12 Gene

Variant ID Type Subtype PubMed ID
dgv1749n100 CNV gain 25217958
dgv1750n100 CNV gain+loss 25217958
dgv1751n100 CNV loss 25217958
dgv1752n100 CNV gain 25217958
dgv1753n100 CNV gain 25217958
dgv1754n100 CNV gain+loss 25217958
dgv1755n100 CNV gain 25217958
dgv1756n100 CNV loss 25217958
dgv1757n100 CNV gain 25217958
dgv1758n100 CNV loss 25217958
dgv1759n100 CNV gain 25217958
dgv33e203 CNV gain+loss 21179565
dgv3489n54 CNV gain 21841781
dgv3494n54 CNV loss 21841781
dgv3496n54 CNV gain 21841781
esv23873 CNV gain+loss 19812545
esv3329579 CNV duplication 20981092
esv3345117 CNV duplication 20981092
esv33527 CNV gain+loss 17666407
esv3392210 CNV duplication 20981092
esv3892461 CNV gain 25118596
esv3892462 CNV gain 25118596
nsv1041718 CNV gain 25217958
nsv1048393 CNV gain+loss 25217958
nsv1049013 CNV gain+loss 25217958
nsv1078357 CNV duplication 25765185
nsv1115450 CNV duplication 24896259
nsv1128688 CNV duplication 24896259
nsv563607 CNV gain 21841781
nsv563608 CNV loss 21841781
nsv819711 CNV loss 19587683
nsv9117 CNV gain+loss 18304495
nsv951946 CNV duplication 24416366
nsv977525 CNV duplication 23825009

Variation tolerance for OR11H12 Gene

Gene Damage Index Score: 13.26; 95.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR11H12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11H12 Gene

Disorders for OR11H12 Gene

Additional Disease Information for OR11H12

No disorders were found for OR11H12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11H12 Gene

Publications for OR11H12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR11H12 Gene

Sources for OR11H12 Gene

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