Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR11H1 Gene

Aliases for OR11H1 Gene

  • Olfactory Receptor Family 11 Subfamily H Member 1 2 3 5
  • Olfactory Receptor OR22-1 3 4
  • Olfactory Receptor, Family 11, Subfamily H, Member 1 2
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 11H1 3
  • OR11H12 3
  • OR22-1 3

External Ids for OR11H1 Gene

Previous GeneCards Identifiers for OR11H1 Gene

  • GC22U990212
  • GC14M019250
  • GC22M014824
  • GC22M016448

Summaries for OR11H1 Gene

Entrez Gene Summary for OR11H1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11H1 Gene

OR11H1 (Olfactory Receptor Family 11 Subfamily H Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H2.

UniProtKB/Swiss-Prot for OR11H1 Gene

  • Odorant receptor.

Gene Wiki entry for OR11H1 Gene

Additional gene information for OR11H1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11H1 Gene

Genomics for OR11H1 Gene

GeneHancer (GH) Regulatory Elements for OR11H1 Gene

Top Transcription factor binding sites by QIAGEN in the OR11H1 gene promoter:
  • Lmo2
  • GATA-1
  • LCR-F1
  • SEF-1 (1)
  • IRF-1
  • AREB6

Genomic Locations for OR11H1 Gene

Genomic Locations for OR11H1 Gene
981 bases
Plus strand
982 bases
Minus strand

Genomic View for OR11H1 Gene

Genes around OR11H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H1 Gene

Proteins for OR11H1 Gene

  • Protein details for OR11H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 11H1
    Protein Accession:
    Secondary Accessions:
    • Q6IEX0
    • Q96R32

    Protein attributes for OR11H1 Gene

    326 amino acids
    Molecular mass:
    36578 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H1 Gene

Post-translational modifications for OR11H1 Gene

  • Glycosylation at Asn106, Asn18, and isoforms=13

Other Protein References for OR11H1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11H1 Gene

Domains & Families for OR11H1 Gene

Gene Families for OR11H1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR11H1 Gene

Suggested Antigen Peptide Sequences for OR11H1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11H1: view

Function for OR11H1 Gene

Molecular function for OR11H1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR11H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11H1: view

Phenotypes for OR11H1 Gene

genes like me logo Genes that share phenotypes with OR11H1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11H1 Gene

Localization for OR11H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11H1 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for OR11H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11H1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR11H1 Gene

Pathways & Interactions for OR11H1 Gene

genes like me logo Genes that share pathways with OR11H1: view

Pathways by source for OR11H1 Gene

Interacting Proteins for OR11H1 Gene

Gene Ontology (GO) - Biological Process for OR11H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11H1: view

No data available for SIGNOR curated interactions for OR11H1 Gene

Drugs & Compounds for OR11H1 Gene

No Compound Related Data Available

Transcripts for OR11H1 Gene

mRNA/cDNA for OR11H1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR11H1 Gene

Olfactory receptor, family 11, subfamily H, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H1 Gene

No ASD Table

Relevant External Links for OR11H1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR11H1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR11H1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR11H1 Gene:


SOURCE GeneReport for Unigene cluster for OR11H1 Gene:

genes like me logo Genes that share expression patterns with OR11H1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11H1 Gene

Orthologs for OR11H1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11H1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC740929 33
  • 98.67 (n)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia LOC102153096 33
  • 87.9 (n)
-- 34
  • 64 (a)
(Bos Taurus)
Mammalia LOC784332 33
  • 86.4 (n)
-- 34
  • 82 (a)
-- 34
  • 78 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 62 (a)
(Mus musculus)
Mammalia Olfr739 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
Species where no ortholog for OR11H1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11H1 Gene

Gene Tree for OR11H1 (if available)
Gene Tree for OR11H1 (if available)

Paralogs for OR11H1 Gene

Paralogs for OR11H1 Gene

(450) SIMAP similar genes for OR11H1 Gene using alignment to 1 proteins:

  • O11H1_HUMAN Pseudogenes for OR11H1 Gene

genes like me logo Genes that share paralogs with OR11H1: view

Variants for OR11H1 Gene

Sequence variations from dbSNP and Humsavar for OR11H1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1001681099 -- 15,527,417(+) T/A/G upstream_transcript_variant
rs1001815162 -- 15,528,591(+) T/C coding_sequence_variant, synonymous_variant
rs1005477883 -- 15,526,517(+) C/T upstream_transcript_variant
rs1010411914 -- 15,528,651(+) G/A coding_sequence_variant, missense_variant
rs1014544652 -- 15,526,593(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR11H1 Gene

Variant ID Type Subtype PubMed ID
dgv168n111 CNV duplication 26073780
dgv4451n100 CNV gain+loss 25217958
dgv4452n100 CNV loss 25217958
dgv4453n100 CNV gain 25217958
dgv7934n54 CNV gain 21841781
dgv98e203 CNV gain+loss 21179565
esv25550 CNV gain+loss 19812545
esv33426 CNV gain+loss 17666407
esv3375795 CNV duplication 20981092
esv3423855 CNV duplication 20981092
esv3584775 CNV loss 24956385
esv995567 CNV loss 20482838
nsv1060635 CNV loss 25217958
nsv1061008 CNV loss 25217958
nsv1077408 CNV duplication 25765185
nsv1115623 CNV duplication 24896259
nsv1118683 CNV duplication 24896259
nsv1147984 CNV duplication 26484159
nsv469638 CNV gain+loss 16826518
nsv471422 CNV gain 19718026
nsv471593 CNV gain+loss 15918152
nsv511070 OTHER inversion 20534489
nsv514958 CNV gain 21397061
nsv821525 CNV duplication 20802225
nsv834116 CNV gain 17160897
nsv953671 CNV duplication 24416366
nsv966126 CNV duplication 23825009
nsv9866 CNV gain+loss 18304495

Variation tolerance for OR11H1 Gene

Gene Damage Index Score: 8.84; 86.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR11H1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11H1 Gene

Disorders for OR11H1 Gene

Additional Disease Information for OR11H1

No disorders were found for OR11H1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11H1 Gene

Publications for OR11H1 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4 58

Products for OR11H1 Gene

Sources for OR11H1 Gene

Loading form....