Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR11H1 Gene

Aliases for OR11H1 Gene

  • Olfactory Receptor Family 11 Subfamily H Member 1 2 3 5
  • Olfactory Receptor OR22-1 3 4
  • Olfactory Receptor 11H1 3 4
  • OR22-1 2 3
  • Olfactory Receptor, Family 11, Subfamily H, Member 1 2
  • Seven Transmembrane Helix Receptor 3
  • OR11H12 3
  • OR11H1 5

External Ids for OR11H1 Gene

Previous GeneCards Identifiers for OR11H1 Gene

  • GC22U990212
  • GC14M019250
  • GC22M014824
  • GC22M016448

Summaries for OR11H1 Gene

Entrez Gene Summary for OR11H1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11H1 Gene

OR11H1 (Olfactory Receptor Family 11 Subfamily H Member 1) is a Protein Coding gene. Diseases associated with OR11H1 include Cloacal Exstrophy. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H12.

UniProtKB/Swiss-Prot Summary for OR11H1 Gene

Gene Wiki entry for OR11H1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR11H1 Gene

Genomics for OR11H1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR11H1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J015602 Enhancer 0.2 Ensembl 0.2 +74.3 74278 0.7 HSALNG0133792 ENSG00000230471 LOC112268291 ENSG00000230643 OR11H1 POTEH
GH22J015603 Enhancer 0.2 Ensembl 0.2 +75.7 75709 1.4 ENSG00000230471 HSALNG0133792 LOC112268291 piR-41958-003 OR11H1 POTEH
GH22J015290 Promoter 0.3 Ensembl 0.1 -237.3 -237291 0.6 ENSG00000236235 lnc-OR11H1-4 piR-40110-448 OR11H1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR11H1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR11H1

Top Transcription factor binding sites by QIAGEN in the OR11H1 gene promoter:
  • AREB6
  • GATA-1
  • IRF-1
  • LCR-F1
  • Lmo2
  • SEF-1 (1)

Genomic Locations for OR11H1 Gene

Latest Assembly
chr22:15,528,192-15,529,139
(GRCh38/hg38)
Size:
948 bases
Orientation:
Plus strand

Previous Assembly
chr22:16,448,824-16,449,804
(GRCh37/hg19 by Entrez Gene)
Size:
981 bases
Orientation:
Minus strand

chr22:16,448,824-16,449,805
(GRCh37/hg19 by Ensembl)
Size:
982 bases
Orientation:
Minus strand

Genomic View for OR11H1 Gene

Genes around OR11H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H1 Gene

Proteins for OR11H1 Gene

  • Protein details for OR11H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG94-O11H1_HUMAN
    Recommended name:
    Olfactory receptor 11H1
    Protein Accession:
    Q8NG94
    Secondary Accessions:
    • Q6IEX0
    • Q96R32

    Protein attributes for OR11H1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36578 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H1 Gene

Post-translational modifications for OR11H1 Gene

  • Glycosylation at Asn13, Asn18, and Asn106

Other Protein References for OR11H1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11H1 Gene

Domains & Families for OR11H1 Gene

Gene Families for OR11H1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR11H1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR11H1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR22-1 (O11H1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NG94

UniProtKB/Swiss-Prot:

O11H1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11H1: view

Function for OR11H1 Gene

Molecular function for OR11H1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR11H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11H1: view

Phenotypes for OR11H1 Gene

genes like me logo Genes that share phenotypes with OR11H1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR11H1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11H1 Gene

Localization for OR11H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11H1 gene
Compartment Confidence
plasma membrane 5
peroxisome 0

Gene Ontology (GO) - Cellular Components for OR11H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11H1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR11H1 Gene

Pathways & Interactions for OR11H1 Gene

genes like me logo Genes that share pathways with OR11H1: view

Pathways by source for OR11H1 Gene

Interacting Proteins for OR11H1 Gene

Gene Ontology (GO) - Biological Process for OR11H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11H1: view

No data available for SIGNOR curated interactions for OR11H1 Gene

Drugs & Compounds for OR11H1 Gene

No Compound Related Data Available

Transcripts for OR11H1 Gene

mRNA/cDNA for OR11H1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR11H1

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H1 Gene

No ASD Table

Relevant External Links for OR11H1 Gene

GeneLoc Exon Structure for
OR11H1

Expression for OR11H1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR11H1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR11H1

SOURCE GeneReport for Unigene cluster for OR11H1 Gene:

Hs.554706
genes like me logo Genes that share expression patterns with OR11H1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11H1 Gene

Orthologs for OR11H1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11H1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC740929 29
  • 98.67 (n)
-- 30
  • 97 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC102153096 29
  • 87.9 (n)
-- 30
  • 64 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia LOC784332 29
  • 86.4 (n)
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 78 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 62 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr739 30
  • 61 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 58 (a)
OneToMany
Species where no ortholog for OR11H1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR11H1 Gene

ENSEMBL:
Gene Tree for OR11H1 (if available)
TreeFam:
Gene Tree for OR11H1 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR11H1

Paralogs for OR11H1 Gene

(450) SIMAP similar genes for OR11H1 Gene using alignment to 1 proteins:

  • O11H1_HUMAN

Pseudogenes.org Pseudogenes for OR11H1 Gene

genes like me logo Genes that share paralogs with OR11H1: view

Variants for OR11H1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR11H1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR11H1 Gene

Variant ID Type Subtype PubMed ID
dgv168n111 CNV duplication 26073780
dgv4451n100 CNV gain+loss 25217958
dgv4452n100 CNV loss 25217958
dgv4453n100 CNV gain 25217958
dgv7934n54 CNV gain 21841781
dgv98e203 CNV gain+loss 21179565
esv25550 CNV gain+loss 19812545
esv33426 CNV gain+loss 17666407
esv3375795 CNV duplication 20981092
esv3423855 CNV duplication 20981092
esv3584775 CNV loss 24956385
esv995567 CNV loss 20482838
nsv1060635 CNV loss 25217958
nsv1061008 CNV loss 25217958
nsv1077408 CNV duplication 25765185
nsv1115623 CNV duplication 24896259
nsv1118683 CNV duplication 24896259
nsv1147984 CNV duplication 26484159
nsv469638 CNV gain+loss 16826518
nsv471422 CNV gain 19718026
nsv471593 CNV gain+loss 15918152
nsv511070 OTHER inversion 20534489
nsv514958 CNV gain 21397061
nsv821525 CNV duplication 20802225
nsv834116 CNV gain 17160897
nsv953671 CNV duplication 24416366
nsv966126 CNV duplication 23825009
nsv9866 CNV gain+loss 18304495

Variation tolerance for OR11H1 Gene

Gene Damage Index Score: 8.84; 86.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR11H1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR11H1
Leiden Open Variation Database (LOVD)
OR11H1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR11H1 Gene

Disorders for OR11H1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR11H1 Gene - From: COP

Disorder Aliases PubMed IDs
cloacal exstrophy
  • omphalocele, exstrophy of the cloaca, imperforate anus, and spinal defects complex
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR11H1

genes like me logo Genes that share disorders with OR11H1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR11H1 Gene

Publications for OR11H1 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 2 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4

Products for OR11H1 Gene

Sources for OR11H1 Gene