Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR11G2 Gene

Aliases for OR11G2 Gene

  • Olfactory Receptor Family 11 Subfamily G Member 2 2 3 5
  • Olfactory Receptor OR14-34 3 4
  • Olfactory Receptor 11G2 3 4
  • Olfactory Receptor, Family 11, Subfamily G, Member 2 2
  • OR14-34 3
  • OR11G2 5

External Ids for OR11G2 Gene

Previous GeneCards Identifiers for OR11G2 Gene

  • GC14U990447
  • GC14P018646
  • GC14P019737
  • GC14P020666
  • GC14P020197

Summaries for OR11G2 Gene

Entrez Gene Summary for OR11G2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11G2 Gene

OR11G2 (Olfactory Receptor Family 11 Subfamily G Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H6.

UniProtKB/Swiss-Prot Summary for OR11G2 Gene

Gene Wiki entry for OR11G2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR11G2 Gene

Genomics for OR11G2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR11G2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020176 Enhancer 1.1 Ensembl ENCODE 0.4 -11.8 -11759 4.9 NCOR1 IKZF1 ZNF592 NFIC NONO HES1 MNT ARNT NFATC3 TAF9B OR11G1P lnc-OR11G2-1 METTL17 OR11G2 OR4N5
GH14J020197 Enhancer 0.3 Ensembl 0.4 +6.9 6907 0.8 SPI1 FJ601684-113 OR11G2 OR11H6
GH14J020204 Enhancer 0.2 Ensembl 0.4 +13.8 13807 0.6 OR11H5P OR4N5 piR-50308-157 OR11G2 OR11H6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR11G2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR11G2

Top Transcription factor binding sites by QIAGEN in the OR11G2 gene promoter:
  • AML1a
  • FAC1
  • MZF-1
  • NRSF form 1
  • NRSF form 2
  • PPAR-gamma1
  • PPAR-gamma2
  • RP58
  • STAT5A
  • STAT5B

Genomic Locations for OR11G2 Gene

Latest Assembly
chr14:20,190,894-20,201,075
(GRCh38/hg38)
Size:
10,182 bases
Orientation:
Plus strand

Previous Assembly
chr14:20,659,055-20,669,234
(GRCh37/hg19 by Entrez Gene)
Size:
10,180 bases
Orientation:
Plus strand

chr14:20,665,495-20,666,605
(GRCh37/hg19 by Ensembl)
Size:
1,111 bases
Orientation:
Plus strand

Genomic View for OR11G2 Gene

Genes around OR11G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11G2 Gene

Proteins for OR11G2 Gene

  • Protein details for OR11G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC1-O11G2_HUMAN
    Recommended name:
    Olfactory receptor 11G2
    Protein Accession:
    Q8NGC1
    Secondary Accessions:
    • Q6IF09
    • Q96R33

    Protein attributes for OR11G2 Gene

    Size:
    345 amino acids
    Molecular mass:
    38871 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06113.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR11G2 Gene

Post-translational modifications for OR11G2 Gene

  • Glycosylation at Asn43
  • Modification sites at PhosphoSitePlus

Other Protein References for OR11G2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11G2 Gene

Domains & Families for OR11G2 Gene

Gene Families for OR11G2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR11G2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR11G2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR14-34 (O11G2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGC1

UniProtKB/Swiss-Prot:

O11G2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11G2: view

Function for OR11G2 Gene

Molecular function for OR11G2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR11G2 Gene

Gene Ontology (GO) - Molecular Function for OR11G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11G2: view
genes like me logo Genes that share phenotypes with OR11G2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR11G2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11G2 Gene

Localization for OR11G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11G2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11G2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11G2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR11G2 Gene

Pathways & Interactions for OR11G2 Gene

genes like me logo Genes that share pathways with OR11G2: view

Pathways by source for OR11G2 Gene

Interacting Proteins for OR11G2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000349930 Q8NGC1-O11G2_HUMAN for OR11G2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR11G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11G2: view

No data available for SIGNOR curated interactions for OR11G2 Gene

Drugs & Compounds for OR11G2 Gene

No Compound Related Data Available

Transcripts for OR11G2 Gene

mRNA/cDNA for OR11G2 Gene

2 REFSEQ mRNAs :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR11G2

Alternative Splicing Database (ASD) splice patterns (SP) for OR11G2 Gene

No ASD Table

Relevant External Links for OR11G2 Gene

GeneLoc Exon Structure for
OR11G2

Expression for OR11G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR11G2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR11G2

SOURCE GeneReport for Unigene cluster for OR11G2 Gene:

Hs.554582
genes like me logo Genes that share expression patterns with OR11G2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11G2 Gene

Orthologs for OR11G2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11G2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC473316 29
  • 98.82 (n)
Cow
(Bos Taurus)
Mammalia OR11G2 29
  • 87.99 (n)
-- 30
  • 83 (a)
OneToMany
-- 30
  • 79 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC482549 29
  • 86.13 (n)
OR11G2 30
  • 82 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or11g2 45 Olfr744 29 16
  • 85.12 (n)
Or11g26 45 Olfr742 30
  • 74 (a)
OneToMany
Or11g1 45 Olfr738
  • chr14:50,413,546-50,414,478
Or11g25 45 Olfr741
  • chr14:50,485,460-50,486,392
Rat
(Rattus norvegicus)
Mammalia Olr1620 29
  • 84 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 77 (a)
OneToMany
-- 30
  • 75 (a)
OneToMany
-- 30
  • 70 (a)
OneToMany
-- 30
  • 65 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 62 (a)
OneToMany
Species where no ortholog for OR11G2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR11G2 Gene

ENSEMBL:
Gene Tree for OR11G2 (if available)
TreeFam:
Gene Tree for OR11G2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR11G2: view image
Alliance of Genome Resources:
Additional Orthologs for OR11G2

Paralogs for OR11G2 Gene

(456) SIMAP similar genes for OR11G2 Gene using alignment to 1 proteins:

  • O11G2_HUMAN

Pseudogenes.org Pseudogenes for OR11G2 Gene

genes like me logo Genes that share paralogs with OR11G2: view

Variants for OR11G2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR11G2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs4981088 -- p.Val116Ile
rs4981822 -- p.Ile99Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR11G2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR11G2 Gene

Variant ID Type Subtype PubMed ID
dgv3532n54 CNV loss 21841781
esv2751268 CNV gain 17911159
esv2761819 CNV loss 21179565
esv3580929 CNV loss 25503493
nsv1037890 CNV gain 25217958
nsv832739 CNV gain 17160897

Variation tolerance for OR11G2 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.07; 99.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR11G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR11G2
Leiden Open Variation Database (LOVD)
OR11G2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11G2 Gene

Disorders for OR11G2 Gene

Additional Disease Information for OR11G2

No disorders were found for OR11G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11G2 Gene

Publications for OR11G2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4

Products for OR11G2 Gene

Sources for OR11G2 Gene