Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR11A1 Gene

Aliases for OR11A1 Gene

  • Olfactory Receptor Family 11 Subfamily A Member 1 2 3 5
  • Hs6M1-18 2 3 4
  • Olfactory Receptor, Family 11, Subfamily A, Member 2 2 3
  • Olfactory Receptor OR6-30 3 4
  • Olfactory Receptor 11A1 3 4
  • Olfactory Receptor 11A2 3 4
  • OR11A2 3 4
  • Olfactory Receptor, Family 11, Subfamily A, Member 1 2
  • DJ994E9.6 3
  • 6M1-18 3
  • OR11A1 5

External Ids for OR11A1 Gene

Previous HGNC Symbols for OR11A1 Gene

  • OR11A2

Previous GeneCards Identifiers for OR11A1 Gene

  • GC06M029451
  • GC06M029165
  • GC06M029501
  • GC06M029432
  • GC06M029393
  • GC06Mo29324

Summaries for OR11A1 Gene

Entrez Gene Summary for OR11A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11A1 Gene

OR11A1 (Olfactory Receptor Family 11 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11G2.

UniProtKB/Swiss-Prot Summary for OR11A1 Gene

Gene Wiki entry for OR11A1 Gene

Additional gene information for OR11A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR11A1 Gene

Genomics for OR11A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR11A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J029516 Enhancer 0.8 Ensembl 11 -59.4 -59381 0.7 PRDM10 ZNF629 ZNF692 ZIC2 ZNF600 ZNF561 SCRT2 ZBTB44 KLF9 ARID3A ZFP57 OR11A1 OR2H1 OR5V1 OR2H2 HLA-W piR-37170-058 LINC02829 MAS1L UBD
GH06J029510 Enhancer 0.6 Ensembl 10.8 -53.2 -53230 0.2 PRDM10 ZIC2 ZNF561 RAD21 CTCF ZBTB48 HIC1 BHLHE40 ZNF366 GLIS1 OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 HLA-W MAS1LP1 piR-37170-058 LINC02829 MAS1L
GH06J029509 Enhancer 0.4 FANTOM5 10.8 -52.2 -52238 0.1 RELA RUNX3 IKZF1 OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 LINC02829 piR-37170-058 MAS1L UBD
GH06J029467 Enhancer 0.2 FANTOM5 11.6 -10.6 -10628 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
GH06J029447 Enhancer 0.6 Ensembl ENCODE 0.4 +9.8 9763 1.4 TEAD4 KDM1A SP1 JUND ZFP57 ENSG00000237669 HCG18 HLA-W ENSG00000277881 OR10C1 OR11A1 OR5V1 LOC105379641
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR11A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR11A1

Top Transcription factor binding sites by QIAGEN in the OR11A1 gene promoter:
  • AML1a
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for OR11A1 Gene

Genomic Locations for OR11A1 Gene
chr6:29,425,504-29,457,071
(GRCh38/hg38)
Size:
31,568 bases
Orientation:
Minus strand
chr6:29,393,281-29,424,848
(GRCh37/hg19)
Size:
31,568 bases
Orientation:
Minus strand

Genomic View for OR11A1 Gene

Genes around OR11A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR11A1 Gene

  • Protein details for OR11A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZK7-O11A1_HUMAN
    Recommended name:
    Olfactory receptor 11A1
    Protein Accession:
    Q9GZK7
    Secondary Accessions:
    • A2BF33
    • A6NFQ3
    • B0S7T2
    • Q5ST16
    • Q9GZK8

    Protein attributes for OR11A1 Gene

    Size:
    315 amino acids
    Molecular mass:
    35250 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11A1 Gene

Post-translational modifications for OR11A1 Gene

  • Glycosylation at Asn8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR11A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11A1 Gene

Domains & Families for OR11A1 Gene

Gene Families for OR11A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR11A1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR11A1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 11, subfamily A, member 1 (A2RRF6_HUMAN)
  • Olfactory receptor OR6-30 (O11A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZK7

UniProtKB/Swiss-Prot:

O11A1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11A1: view

Function for OR11A1 Gene

Molecular function for OR11A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 11,subfamily A,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR11A1 Gene

Gene Ontology (GO) - Molecular Function for OR11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11A1: view
genes like me logo Genes that share phenotypes with OR11A1: view

Animal Model Products

CRISPR Products

miRNA for OR11A1 Gene

miRTarBase miRNAs that target OR11A1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR11A1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR11A1 Gene

Localization for OR11A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11A1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR11A1 Gene

Pathways & Interactions for OR11A1 Gene

genes like me logo Genes that share pathways with OR11A1: view

Pathways by source for OR11A1 Gene

1 BioSystems pathway for OR11A1 Gene
1 KEGG pathway for OR11A1 Gene

Interacting Proteins for OR11A1 Gene

Gene Ontology (GO) - Biological Process for OR11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11A1: view

No data available for SIGNOR curated interactions for OR11A1 Gene

Drugs & Compounds for OR11A1 Gene

No Compound Related Data Available

Transcripts for OR11A1 Gene

mRNA/cDNA for OR11A1 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR11A1

Alternative Splicing Database (ASD) splice patterns (SP) for OR11A1 Gene

No ASD Table

Relevant External Links for OR11A1 Gene

GeneLoc Exon Structure for
OR11A1

Expression for OR11A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR11A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR11A1 Gene

This gene is overexpressed in Testis (x36.8).

Protein differential expression in normal tissues from HIPED for OR11A1 Gene

This gene is overexpressed in Stomach (44.8) and Frontal cortex (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR11A1 Gene



Protein tissue co-expression partners for OR11A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR11A1

SOURCE GeneReport for Unigene cluster for OR11A1 Gene:

Hs.676010

Evidence on tissue expression from TISSUES for OR11A1 Gene

  • Lung(2.3)
genes like me logo Genes that share expression patterns with OR11A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11A1 Gene

Orthologs for OR11A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR11A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC471941 30
  • 97.67 (n)
OR11A1 31
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC523389 30
  • 84.55 (n)
-- 31
  • 79 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or11a4 46 Olfr96 30 17 31
  • 79.17 (n)
OneToOne
Or11a2-ps 46 Olfr754-ps1
  • chr17:37,250,213-37,250,888
Or11a3-ps 46 Olfr755-ps1
  • chr17:37,277,435-37,278,087
Or11a5-ps 46 Olfr759-ps1
  • chr17:37,407,837-37,408,481
Or11a6-ps 46 Olfr760-ps1
  • chr17:37,451,436-37,452,000
Rat
(Rattus norvegicus)
Mammalia Olr1743 30
  • 78.31 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR11A1 31
  • 74 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR28H03 31
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OR11A1 31
  • 44 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 46 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
Species where no ortholog for OR11A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR11A1 Gene

ENSEMBL:
Gene Tree for OR11A1 (if available)
TreeFam:
Gene Tree for OR11A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR11A1: view image

Paralogs for OR11A1 Gene

(456) SIMAP similar genes for OR11A1 Gene using alignment to 2 proteins:

  • O11A1_HUMAN
  • A2RRF6_HUMAN

Pseudogenes.org Pseudogenes for OR11A1 Gene

genes like me logo Genes that share paralogs with OR11A1: view

Variants for OR11A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR11A1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs16894898 - p.Tyr121Cys
rs9257857 - p.Ala165Thr

Additional dbSNP identifiers (rs#s) for OR11A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR11A1 Gene

Variant ID Type Subtype PubMed ID
esv3570836 CNV loss 25503493
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv830624 CNV loss 17160897

Variation tolerance for OR11A1 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.26; 76.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR11A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR11A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11A1 Gene

Disorders for OR11A1 Gene

Additional Disease Information for OR11A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for OR11A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11A1 Gene

Publications for OR11A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  5. Complex transcription and splicing of odorant receptor genes. (PMID: 12637542) Volz A … Ziegler A (The Journal of biological chemistry 2003) 3 4

Products for OR11A1 Gene

Sources for OR11A1 Gene