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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR11A1 (Olfactory Receptor Family 11 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11G2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J029516 | Enhancer | 0.8 | Ensembl | 11 | -59.4 | -59381 | 0.7 | PRDM10 ZNF629 ZNF692 ZIC2 ZNF600 ZNF561 SCRT2 ZBTB44 KLF9 ARID3A | ZFP57 OR11A1 OR2H1 OR5V1 OR2H2 HLA-W piR-37170-058 LINC02829 MAS1L UBD | |
GH06J029510 | Enhancer | 0.6 | Ensembl | 10.8 | -53.2 | -53230 | 0.2 | PRDM10 ZIC2 ZNF561 RAD21 CTCF ZBTB48 HIC1 BHLHE40 ZNF366 GLIS1 | OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 HLA-W MAS1LP1 piR-37170-058 LINC02829 MAS1L | |
GH06J029509 | Enhancer | 0.4 | FANTOM5 | 10.8 | -52.2 | -52238 | 0.1 | RELA RUNX3 IKZF1 | OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 LINC02829 piR-37170-058 MAS1L UBD | |
GH06J029467 | Enhancer | 0.2 | FANTOM5 | 11.6 | -10.6 | -10628 | 0.3 | OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1 | ||
GH06J029447 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | +9.8 | 9763 | 1.4 | TEAD4 KDM1A SP1 JUND | ZFP57 ENSG00000237669 HCG18 HLA-W ENSG00000277881 OR10C1 OR11A1 OR5V1 LOC105379641 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC471941 30 |
|
||
OR11A1 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | LOC523389 30 |
|
||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Or11a4 46 Olfr96 30 17 31 |
|
OneToOne |
|
Or11a2-ps 46 Olfr754-ps1 |
|
|
|||
Or11a3-ps 46 Olfr755-ps1 |
|
|
|||
Or11a5-ps 46 Olfr759-ps1 |
|
|
|||
Or11a6-ps 46 Olfr760-ps1 |
|
|
|||
Rat (Rattus norvegicus) |
Mammalia | Olr1743 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | OR11A1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | OR28H03 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | OR11A1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs16894898 | - | p.Tyr121Cys | |||
rs9257857 | - | p.Ala165Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3570836 | CNV | loss | 25503493 |
nsv1074389 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1145096 | CNV | deletion | 24896259 |
nsv830624 | CNV | loss | 17160897 |
No disorders were found for OR11A1 Gene.