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Aliases for OR10Z1 Gene

Aliases for OR10Z1 Gene

  • Olfactory Receptor Family 10 Subfamily Z Member 1 2 3 5
  • Olfactory Receptor OR1-15 3 4
  • Olfactory Receptor, Family 10, Subfamily Z, Member 1 2
  • Olfactory Receptor 10Z1 3
  • OR1-15 3

External Ids for OR10Z1 Gene

Previous GeneCards Identifiers for OR10Z1 Gene

  • GC01U990421
  • GC01P155793
  • GC01P155389
  • GC01P156842

Summaries for OR10Z1 Gene

Entrez Gene Summary for OR10Z1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10Z1 Gene

OR10Z1 (Olfactory Receptor Family 10 Subfamily Z Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR10J1.

UniProtKB/Swiss-Prot for OR10Z1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10Z1 Gene

Additional gene information for OR10Z1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10Z1 Gene

Genomics for OR10Z1 Gene

GeneHancer (GH) Regulatory Elements for OR10Z1 Gene

Promoters and enhancers for OR10Z1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J158972 Enhancer 0.4 FANTOM5 5.3 +367.8 367763 0.2 CTCF RAD21 FCER1A OR6N1 OR6K3 OR10Z1 DUSP23 OR10R2 OR10X1 OR6N2 PYHIN1 OR6P1
GH01J159024 Enhancer 0.5 FANTOM5 dbSUPER 2.6 +419.9 419860 0.5 OR6N1 OR6K3 FCER1A OR6N2 OR10Z1 IFI16 OR10X1 OR6P1 MNDA GC01M159011
GH01J158689 Enhancer 0.7 FANTOM5 1.4 +84.0 84015 0.1 TEAD4 TAL1 CC2D1A TCF12 GATA2 NCOR1 CBFA2T2 SMARCE1 MTA2 CBFA2T3 SPTA1 OR6N1 OR6K3 OR10K1 OR10Z1 OR6K1P
GH01J158685 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 0.2 +81.2 81185 1.2 ATF1 ARNT TCF12 POLR2B ZNF766 NCOA1 ATF4 SMARCA4 MYNN NBN SPTA1 OR10Z1
GH01J158646 Enhancer 0.5 FANTOM5 Ensembl 0.3 +41.3 41293 0.7 REST IFI16 OR10Z1 SPTA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10Z1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10Z1 gene promoter:
  • FOXF2
  • HTF
  • NF-1/L
  • NF-1
  • C/EBPalpha
  • Brachyury
  • CBF(2)
  • CBF-A
  • CP1A
  • NF-Y

Genomic Locations for OR10Z1 Gene

Genomic Locations for OR10Z1 Gene
7,247 bases
Plus strand
942 bases
Plus strand

Genomic View for OR10Z1 Gene

Genes around OR10Z1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10Z1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10Z1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10Z1 Gene

Proteins for OR10Z1 Gene

  • Protein details for OR10Z1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10Z1
    Protein Accession:
    Secondary Accessions:
    • Q5VYL0
    • Q6IFR7

    Protein attributes for OR10Z1 Gene

    313 amino acids
    Molecular mass:
    34609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10Z1 Gene

Post-translational modifications for OR10Z1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10Z1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10Z1 Gene

Domains & Families for OR10Z1 Gene

Gene Families for OR10Z1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10Z1 Gene

Suggested Antigen Peptide Sequences for OR10Z1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10Z1: view

Function for OR10Z1 Gene

Molecular function for OR10Z1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10Z1 Gene

Gene Ontology (GO) - Molecular Function for OR10Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10Z1: view
genes like me logo Genes that share phenotypes with OR10Z1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10Z1 Gene

Localization for OR10Z1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10Z1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10Z1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10Z1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10Z1 Gene

Pathways & Interactions for OR10Z1 Gene

genes like me logo Genes that share pathways with OR10Z1: view

Pathways by source for OR10Z1 Gene

Interacting Proteins for OR10Z1 Gene

Gene Ontology (GO) - Biological Process for OR10Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR10Z1: view

No data available for SIGNOR curated interactions for OR10Z1 Gene

Drugs & Compounds for OR10Z1 Gene

No Compound Related Data Available

Transcripts for OR10Z1 Gene

mRNA/cDNA for OR10Z1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10Z1 Gene

Olfactory receptor, family 10, subfamily Z, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10Z1 Gene

No ASD Table

Relevant External Links for OR10Z1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10Z1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10Z1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10Z1 Gene:


SOURCE GeneReport for Unigene cluster for OR10Z1 Gene:

genes like me logo Genes that share expression patterns with OR10Z1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10Z1 Gene

Orthologs for OR10Z1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10Z1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC469532 33
  • 99.25 (n)
OR10Z1 34
  • 99 (a)
(Canis familiaris)
Mammalia OR10Z1 34 33
  • 85.41 (n)
(Bos Taurus)
Mammalia OR10Z1 34 33
  • 85.3 (n)
(Mus musculus)
Mammalia Or10z1 51 Olfr419 16 34 33
  • 83.39 (n)
(Rattus norvegicus)
Mammalia Olr1597 33
  • 82 (n)
(Monodelphis domestica)
Mammalia OR10Z1 34
  • 78 (a)
Species where no ortholog for OR10Z1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10Z1 Gene

Gene Tree for OR10Z1 (if available)
Gene Tree for OR10Z1 (if available)
Evolutionary constrained regions (ECRs) for OR10Z1: view image

Paralogs for OR10Z1 Gene

(456) SIMAP similar genes for OR10Z1 Gene using alignment to 1 proteins:

  • O10Z1_HUMAN
genes like me logo Genes that share paralogs with OR10Z1: view

Variants for OR10Z1 Gene

Sequence variations from dbSNP and Humsavar for OR10Z1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000112504 -- 158,605,290(+) A/G upstream_transcript_variant
rs1000417566 -- 158,607,125(+) C/T coding_sequence_variant, synonymous_variant
rs1001333654 -- 158,606,499(+) G/T coding_sequence_variant, missense_variant
rs1002058933 -- 158,606,026(+) G/A upstream_transcript_variant
rs1003552058 -- 158,604,893(+) G/A upstream_transcript_variant

Variation tolerance for OR10Z1 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.84; 83.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10Z1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR10Z1 Gene

Disorders for OR10Z1 Gene

Additional Disease Information for OR10Z1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR10Z1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10Z1 Gene

Publications for OR10Z1 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. Seventy-five genetic loci influencing the human red blood cell. (PMID: 23222517) van der Harst P … Chambers JC (Nature 2012) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10Z1 Gene

Sources for OR10Z1 Gene

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