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Aliases for OR10X1 Gene

Aliases for OR10X1 Gene

  • Olfactory Receptor Family 10 Subfamily X Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR1-14 3 4
  • OR10X1P 3 4
  • Olfactory Receptor, Family 10, Subfamily X, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 10, Subfamily X, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 10, Subfamily X, Member 1 2
  • Olfactory Receptor OR1-13 Pseudogene 3
  • Olfactory Receptor 10X1 3
  • OR1-13 3
  • OR1-14 3

External Ids for OR10X1 Gene

Previous HGNC Symbols for OR10X1 Gene

  • OR10X1P

Previous GeneCards Identifiers for OR10X1 Gene

  • GC01M155766
  • GC01M155361
  • GC01M156815

Summaries for OR10X1 Gene

Entrez Gene Summary for OR10X1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR10X1 Gene

OR10X1 (Olfactory Receptor Family 10 Subfamily X Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H2.

UniProtKB/Swiss-Prot for OR10X1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10X1 Gene

Additional gene information for OR10X1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10X1 Gene

Genomics for OR10X1 Gene

GeneHancer (GH) Regulatory Elements for OR10X1 Gene

Promoters and enhancers for OR10X1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J158793 Enhancer 0.5 dbSUPER 9.4 -215.7 -215732 4 CTCF ZNF143 REST RAD21 OR2AQ1P OR6N1 SPTA1 OR6K6 OR6K2 OR10X1 OR6N2
GH01J158969 Enhancer 0.4 ENCODE 9.6 -390.1 -390100 1.1 FOSL1 NFE2 FOS OR6N2 OR6N1 OR10X1 ACKR1 PIR57461 IFI16 PYHIN1
GH01J158845 Enhancer 0.3 dbSUPER 9.8 -267.1 -267114 3.4 MNT MNDA OR6N1 OR6N2 OR10X1 ELL2P1 PYHIN5P
GH01J158361 Enhancer 0.3 dbSUPER 9.5 +215.8 215827 4.2 FOXA2 CD1B OR10T2 CD1C OR10K2 OR10X1 CD1E
GH01J158434 Enhancer 0.3 dbSUPER 9.3 +144.0 143996 3.2 CUX1 OR10T2 OR10R2 OR6K2 OR10X1 CD1B OR10K2 OR10T1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10X1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10X1 gene promoter:
  • SRY
  • C/EBPbeta
  • E47
  • Tal-1beta
  • POU2F1
  • POU2F1a
  • AML1a
  • AP-1
  • c-Fos
  • JunD

Genomic Locations for OR10X1 Gene

Genomic Locations for OR10X1 Gene
981 bases
Minus strand
981 bases
Minus strand

Genomic View for OR10X1 Gene

Genes around OR10X1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10X1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10X1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10X1 Gene

Proteins for OR10X1 Gene

  • Protein details for OR10X1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10X1
    Protein Accession:
    Secondary Accessions:
    • Q6IFR8

    Protein attributes for OR10X1 Gene

    326 amino acids
    Molecular mass:
    36446 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05862.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH72417.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR10X1 Gene

Post-translational modifications for OR10X1 Gene

  • Glycosylation at Asn209 and isoforms=21
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10X1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10X1 Gene

Domains & Families for OR10X1 Gene

Gene Families for OR10X1 Gene

Protein Domains for OR10X1 Gene

Suggested Antigen Peptide Sequences for OR10X1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10X1: view

Function for OR10X1 Gene

Molecular function for OR10X1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10X1 Gene

Gene Ontology (GO) - Molecular Function for OR10X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10X1: view
genes like me logo Genes that share phenotypes with OR10X1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10X1 Gene

Localization for OR10X1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10X1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10X1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10X1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10X1 Gene

Pathways & Interactions for OR10X1 Gene

genes like me logo Genes that share pathways with OR10X1: view

Pathways by source for OR10X1 Gene

Interacting Proteins for OR10X1 Gene

Gene Ontology (GO) - Biological Process for OR10X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10X1: view

No data available for SIGNOR curated interactions for OR10X1 Gene

Drugs & Compounds for OR10X1 Gene

No Compound Related Data Available

Transcripts for OR10X1 Gene

mRNA/cDNA for OR10X1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10X1 Gene

Olfactory receptor, family 10, subfamily X, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10X1 Gene

No ASD Table

Relevant External Links for OR10X1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10X1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10X1 Gene

Protein differential expression in normal tissues from HIPED for OR10X1 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10X1 Gene

Protein tissue co-expression partners for OR10X1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10X1 Gene:


SOURCE GeneReport for Unigene cluster for OR10X1 Gene:

genes like me logo Genes that share expression patterns with OR10X1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10X1 Gene

Orthologs for OR10X1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10X1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC469531 33
  • 98.57 (n)
(Bos Taurus)
Mammalia LOC513494 33
  • 86.14 (n)
(Mus musculus)
Mammalia Or10x1 51 Olfr417 16 33
  • 84.26 (n)
Or10l1-ps 51 Olfr416-ps1
  • chr1:174,374,538-174,375,041
Or10x4 51 Olfr248
  • chr1:174,391,071-174,391,997
(Rattus norvegicus)
Mammalia Olr1598 33
  • 84.25 (n)
(Canis familiaris)
Mammalia OR10X1 33
  • 83.44 (n)
Species where no ortholog for OR10X1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10X1 Gene

Gene Tree for OR10X1 (if available)
Gene Tree for OR10X1 (if available)

Paralogs for OR10X1 Gene

(447) SIMAP similar genes for OR10X1 Gene using alignment to 1 proteins:

  • O10X1_HUMAN
genes like me logo Genes that share paralogs with OR10X1: view

Variants for OR10X1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR10X1 Gene

A stop codon at position Trp-66 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Sequence variations from dbSNP and Humsavar for OR10X1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000780176 -- 158,580,676(-) T/C upstream_transcript_variant
rs1002417621 -- 158,579,625(-) G/A coding_sequence_variant, missense_variant
rs1004816770 -- 158,581,630(-) T/C upstream_transcript_variant
rs1004827880 -- 158,579,911(-) A/G upstream_transcript_variant
rs1004878822 -- 158,579,556(-) A/G coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10X1 Gene

Variant ID Type Subtype PubMed ID
nsv547986 CNV loss 21841781

Variation tolerance for OR10X1 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10X1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for OR10X1 Gene

Additional Disease Information for OR10X1

No disorders were found for OR10X1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10X1 Gene

Publications for OR10X1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 58
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58
  5. Different noses for different people. (PMID: 12730696) Menashe I … Gilad Y (Nature genetics 2003) 4 58

Products for OR10X1 Gene

Sources for OR10X1 Gene

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