Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10W1 Gene

Aliases for OR10W1 Gene

  • Olfactory Receptor Family 10 Subfamily W Member 1 2 3 5
  • Olfactory Receptor, Family 10, Subfamily W, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR11-236 3 4
  • Olfactory Receptor 10W1 3 4
  • OR10W1P 3 4
  • Olfactory Receptor, Family 10, Subfamily W, Member 1 2
  • OR11-236 3
  • OR10W1Q 3
  • UNQ6469 3
  • OR10W1 5

External Ids for OR10W1 Gene

Previous HGNC Symbols for OR10W1 Gene

  • OR10W1P

Previous GeneCards Identifiers for OR10W1 Gene

  • GC11U900581
  • GC11M057790
  • GC11M058035

Summaries for OR10W1 Gene

Entrez Gene Summary for OR10W1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10W1 Gene

OR10W1 (Olfactory Receptor Family 10 Subfamily W Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR10Q1.

UniProtKB/Swiss-Prot Summary for OR10W1 Gene

Gene Wiki entry for OR10W1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10W1 Gene

Genomics for OR10W1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10W1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J058164 Enhancer 0.8 ENCODE 9.9 +102.9 102941 2 CEBPA CHD4 THAP11 FOXA2 KDM6A SMAD4 SAP130 ETV4 MIER3 RARA HSALNG0084335 OR9Q2 OR1S2 OR10W1 RNU6-899P OR9Q1 MED19 TIMM10 OR5BL1P OR9I1
GH11J058316 Enhancer 0.5 Ensembl 11.3 -48.0 -48041 0.6 MAFK ZNF24 JUND NFE2L2 SPI1 FOS OR10W1 OR1S2 OR5B2 lnc-OR5B17-2 piR-31922-003 OR5B17
GH11J057946 Enhancer 0.2 FANTOM5 12.2 +321.8 321826 0 OR5BD1P piR-38352-080 lnc-OR9I1-4 piR-50308-086 OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12
GH11J058163 Enhancer 0.2 Ensembl 9.9 +104.5 104459 0.4 HSALNG0084335 OR1S2 OR9Q2 OR10W1 OR9Q1 RNU6-899P OR9I2P OR9I1
GH11J058632 Enhancer 0.2 FANTOM5 8 -364.0 -363981 0.1 OR5B12 OR1S1 OR5B3 OR10W1 OR10Q1 OR5B2 OR9Q2 OR1S2 ENSG00000280010 HSALNG0084356
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10W1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10W1

Top Transcription factor binding sites by QIAGEN in the OR10W1 gene promoter:
  • AML1a
  • ATF6
  • C/EBPalpha
  • Cdc5
  • CHOP-10
  • CP2
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for OR10W1 Gene

Latest Assembly
chr11:58,266,792-58,268,260
(GRCh38/hg38)
Size:
1,469 bases
Orientation:
Minus strand

Previous Assembly
chr11:58,034,264-58,035,732
(GRCh37/hg19 by Entrez Gene)
Size:
1,469 bases
Orientation:
Minus strand

chr11:58,034,264-58,035,732
(GRCh37/hg19 by Ensembl)
Size:
1,469 bases
Orientation:
Minus strand

Genomic View for OR10W1 Gene

Genes around OR10W1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10W1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10W1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10W1 Gene

Proteins for OR10W1 Gene

  • Protein details for OR10W1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF6-O10W1_HUMAN
    Recommended name:
    Olfactory receptor 10W1
    Protein Accession:
    Q8NGF6
    Secondary Accessions:
    • A2RUD2
    • A8MTE1
    • Q6UXQ2

    Protein attributes for OR10W1 Gene

    Size:
    305 amino acids
    Molecular mass:
    33376 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10W1 Gene

Post-translational modifications for OR10W1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR10W1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10W1 Gene

Domains & Families for OR10W1 Gene

Gene Families for OR10W1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10W1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10W1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-236 (O10W1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGF6

UniProtKB/Swiss-Prot:

O10W1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10W1: view

Function for OR10W1 Gene

Molecular function for OR10W1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10W1 Gene

Gene Ontology (GO) - Molecular Function for OR10W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR10W1: view
genes like me logo Genes that share phenotypes with OR10W1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10W1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10W1 Gene

Localization for OR10W1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10W1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10W1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10W1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10W1 Gene

Pathways & Interactions for OR10W1 Gene

genes like me logo Genes that share pathways with OR10W1: view

Pathways by source for OR10W1 Gene

Interacting Proteins for OR10W1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000378516 Q8NGF6-O10W1_HUMAN for OR10W1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR10W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10W1: view

No data available for SIGNOR curated interactions for OR10W1 Gene

Drugs & Compounds for OR10W1 Gene

No Compound Related Data Available

Transcripts for OR10W1 Gene

mRNA/cDNA for OR10W1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10W1

Alternative Splicing Database (ASD) splice patterns (SP) for OR10W1 Gene

No ASD Table

Relevant External Links for OR10W1 Gene

GeneLoc Exon Structure for
OR10W1

Expression for OR10W1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10W1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10W1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10W1

SOURCE GeneReport for Unigene cluster for OR10W1 Gene:

Hs.531507
genes like me logo Genes that share expression patterns with OR10W1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10W1 Gene

Orthologs for OR10W1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10W1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia LOC610022 29
  • 86.34 (n)
OR16F10 30
  • 83 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC531571 29
  • 81.31 (n)
OR10W1 30
  • 73 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or10w1 45 Olfr1490 29 16 30
  • 81.14 (n)
OneToOne
Or10w3 45 Olfr1493
  • chr19:13,726,224-13,727,210
Rat
(Rattus norvegicus)
Mammalia Olr372 29
  • 80.15 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 70 (a)
OneToMany
-- 30
  • 66 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 42 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 44 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia OR10W1 30
  • 55 (a)
OneToOne
Species where no ortholog for OR10W1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10W1 Gene

ENSEMBL:
Gene Tree for OR10W1 (if available)
TreeFam:
Gene Tree for OR10W1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10W1: view image
Alliance of Genome Resources:
Additional Orthologs for OR10W1

Paralogs for OR10W1 Gene

(432) SIMAP similar genes for OR10W1 Gene using alignment to 1 proteins:

  • O10W1_HUMAN
genes like me logo Genes that share paralogs with OR10W1: view

Variants for OR10W1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10W1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10792156 -- p.Arg263Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10W1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR10W1 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10W1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10W1
Leiden Open Variation Database (LOVD)
OR10W1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR10W1 Gene

Disorders for OR10W1 Gene

Additional Disease Information for OR10W1

No disorders were found for OR10W1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10W1 Gene

Publications for OR10W1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR10W1 Gene

Sources for OR10W1 Gene