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Aliases for OR10T2 Gene

Aliases for OR10T2 Gene

  • Olfactory Receptor Family 10 Subfamily T Member 2 2 3 5
  • Olfactory Receptor OR1-3 3 4
  • Olfactory Receptor, Family 10, Subfamily T, Member 2 2
  • Olfactory Receptor 10T2 3
  • OR1-3 3

External Ids for OR10T2 Gene

Previous GeneCards Identifiers for OR10T2 Gene

  • GC01U990368
  • GC01M155586
  • GC01M155181
  • GC01M156635

Summaries for OR10T2 Gene

Entrez Gene Summary for OR10T2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10T2 Gene

OR10T2 (Olfactory Receptor Family 10 Subfamily T Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR10R2.

UniProtKB/Swiss-Prot for OR10T2 Gene

  • Odorant receptor.

Gene Wiki entry for OR10T2 Gene

Additional gene information for OR10T2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10T2 Gene

Genomics for OR10T2 Gene

GeneHancer (GH) Regulatory Elements for OR10T2 Gene

Promoters and enhancers for OR10T2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I158399 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 +0.1 58 0.1 OR10T2 CD1E
GH01I158400 Enhancer 0.5 FANTOM5 dbSUPER 552.5 -1.6 -1559 0.3 OR10T2 CD1E CD1B OR10K1 OR6K3 OR6N1 OR10K2
GH01I157991 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.3 +392.0 391955 32.2 GLI4 ZNF2 ETS1 ZNF121 GLIS2 ZNF213 ZNF143 FOS RUNX3 MCM3 KIRREL1 LOC246784 CD1E OR10T2 KIRREL1-IT1
GH01I158370 Enhancer 0.5 dbSUPER 11.2 +28.2 28181 0.6 IKZF1 EBF1 BATF IKZF2 IRF4 RUNX3 RELA OR10T2 CD1E
GH01I158369 Enhancer 0.4 dbSUPER 11.2 +29.1 29116 1.2 ZNF316 CREB1 OR10T2 CD1E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR10T2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10T2 gene promoter:

Genomic Locations for OR10T2 Gene

Genomic Locations for OR10T2 Gene
chr1:158,398,522-158,399,466
(GRCh38/hg38)
Size:
945 bases
Orientation:
Minus strand
chr1:158,368,312-158,369,256
(GRCh37/hg19)

Genomic View for OR10T2 Gene

Genes around OR10T2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10T2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10T2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10T2 Gene

Proteins for OR10T2 Gene

  • Protein details for OR10T2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGX3-O10T2_HUMAN
    Recommended name:
    Olfactory receptor 10T2
    Protein Accession:
    Q8NGX3
    Secondary Accessions:
    • Q6IF98

    Protein attributes for OR10T2 Gene

    Size:
    314 amino acids
    Molecular mass:
    35011 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10T2 Gene

Post-translational modifications for OR10T2 Gene

Other Protein References for OR10T2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10T2 Gene

Domains & Families for OR10T2 Gene

Gene Families for OR10T2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10T2 Gene

Suggested Antigen Peptide Sequences for OR10T2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGX3

UniProtKB/Swiss-Prot:

O10T2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10T2: view

Function for OR10T2 Gene

Molecular function for OR10T2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10T2 Gene

Gene Ontology (GO) - Molecular Function for OR10T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10T2: view

Phenotypes for OR10T2 Gene

GenomeRNAi human phenotypes for OR10T2:
genes like me logo Genes that share phenotypes with OR10T2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10T2 Gene

Localization for OR10T2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10T2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10T2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10T2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10T2 Gene

Pathways & Interactions for OR10T2 Gene

genes like me logo Genes that share pathways with OR10T2: view

Pathways by source for OR10T2 Gene

Interacting Proteins for OR10T2 Gene

Gene Ontology (GO) - Biological Process for OR10T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR10T2: view

No data available for SIGNOR curated interactions for OR10T2 Gene

Drugs & Compounds for OR10T2 Gene

No Compound Related Data Available

Transcripts for OR10T2 Gene

mRNA/cDNA for OR10T2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10T2 Gene

No ASD Table

Relevant External Links for OR10T2 Gene

GeneLoc Exon Structure for
OR10T2
ECgene alternative splicing isoforms for
OR10T2

Expression for OR10T2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10T2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10T2 Gene:

OR10T2

SOURCE GeneReport for Unigene cluster for OR10T2 Gene:

Hs.553588
genes like me logo Genes that share expression patterns with OR10T2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10T2 Gene

Orthologs for OR10T2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10T2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469525 33
  • 99.47 (n)
OR10T2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR10T2 34
  • 90 (a)
OneToOne
LOC610659 33
  • 87.54 (n)
cow
(Bos Taurus)
Mammalia OR10T2 33 34
  • 89.53 (n)
oppossum
(Monodelphis domestica)
Mammalia OR10T2 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1408 34
  • 52 (a)
ManyToMany
Species where no ortholog for OR10T2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10T2 Gene

ENSEMBL:
Gene Tree for OR10T2 (if available)
TreeFam:
Gene Tree for OR10T2 (if available)

Paralogs for OR10T2 Gene

(450) SIMAP similar genes for OR10T2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR10T2 Gene

genes like me logo Genes that share paralogs with OR10T2: view

Variants for OR10T2 Gene

Sequence variations from dbSNP and Humsavar for OR10T2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000062398 -- 158,400,364(-) A/T upstream_transcript_variant
rs1000277821 -- 158,399,945(-) G/A upstream_transcript_variant
rs1001075691 -- 158,399,413(-) G/A coding_sequence_variant, synonymous_variant
rs1004015168 -- 158,401,399(-) C/A upstream_transcript_variant
rs1004701314 -- 158,401,035(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10T2 Gene

Variant ID Type Subtype PubMed ID
nsv831692 CNV gain 17160897

Variation tolerance for OR10T2 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.20; 96.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10T2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10T2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10T2 Gene

Disorders for OR10T2 Gene

Additional Disease Information for OR10T2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR10T2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10T2 Gene

Publications for OR10T2 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58

Products for OR10T2 Gene

Sources for OR10T2 Gene

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