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Aliases for OR10S1 Gene

Aliases for OR10S1 Gene

  • Olfactory Receptor Family 10 Subfamily S Member 1 2 3 5
  • Olfactory Receptor OR11-279 3 4
  • Olfactory Receptor, Family 10, Subfamily S, Member 1 2
  • Olfactory Receptor 10S1 3
  • OR11-279 3

External Ids for OR10S1 Gene

Previous GeneCards Identifiers for OR10S1 Gene

  • GC11U990360
  • GC11M123386
  • GC11M123353
  • GC11M123849

Summaries for OR10S1 Gene

Entrez Gene Summary for OR10S1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10S1 Gene

OR10S1 (Olfactory Receptor Family 10 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G2.

UniProtKB/Swiss-Prot for OR10S1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10S1 Gene

Additional gene information for OR10S1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10S1 Gene

Genomics for OR10S1 Gene

GeneHancer (GH) Regulatory Elements for OR10S1 Gene

Promoters and enhancers for OR10S1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123977 Enhancer 0.6 ENCODE 650.7 -0.3 -348 2 SOX6 CEBPB CEBPG ZEB2 EP300 ATF4 CTBP1 NFE2 TRIM24 EMSY GC11M123977 OR10S1 ZNF202 OR6T1
GH11J123740 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 1.4 +235.7 235708 3.8 HNRNPUL1 PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF202 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P OR4D5 TMEM225
GH11J124008 Enhancer 0.2 FANTOM5 11.2 -30.9 -30893 0.4 OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR10G4 OR6M1 OR8G1 OR10S1 OR8D2
GH11J123583 Enhancer 0.2 FANTOM5 1.5 +393.9 393913 0.4 OR10G7 OR6X1 OR10G4 OR6T1 OR4D5 OR6M1 OR8D4 OR10S1 GC11M123576 GC11M123593
GH11J123695 Enhancer 0.2 FANTOM5 1.5 +282.4 282447 0.4 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1 OR10G9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10S1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10S1 gene promoter:
  • Tal-1
  • E47
  • AREB6
  • NF-1
  • NF-1/L
  • PPAR-alpha
  • AML1a
  • ITF-2
  • Tal-1beta
  • PPAR-gamma2

Genomic Locations for OR10S1 Gene

Genomic Locations for OR10S1 Gene
1,121 bases
Minus strand
1,121 bases
Minus strand

Genomic View for OR10S1 Gene

Genes around OR10S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10S1 Gene

Proteins for OR10S1 Gene

  • Protein details for OR10S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10S1
    Protein Accession:
    Secondary Accessions:
    • B9EH43
    • Q6IEV3
    • Q96R78

    Protein attributes for OR10S1 Gene

    331 amino acids
    Molecular mass:
    36501 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05978.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR10S1 Gene

Post-translational modifications for OR10S1 Gene

  • Glycosylation at isoforms=18
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10S1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10S1 Gene

Domains & Families for OR10S1 Gene

Gene Families for OR10S1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10S1 Gene

Suggested Antigen Peptide Sequences for OR10S1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10S1: view

Function for OR10S1 Gene

Molecular function for OR10S1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10S1: view
genes like me logo Genes that share phenotypes with OR10S1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10S1 Gene

Localization for OR10S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10S1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10S1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10S1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10S1 Gene

Pathways & Interactions for OR10S1 Gene

genes like me logo Genes that share pathways with OR10S1: view

Pathways by source for OR10S1 Gene

Interacting Proteins for OR10S1 Gene

Gene Ontology (GO) - Biological Process for OR10S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10S1: view

No data available for SIGNOR curated interactions for OR10S1 Gene

Drugs & Compounds for OR10S1 Gene

No Compound Related Data Available

Transcripts for OR10S1 Gene

mRNA/cDNA for OR10S1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10S1 Gene

Olfactory receptor, family 10, subfamily S, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10S1 Gene

No ASD Table

Relevant External Links for OR10S1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10S1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10S1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10S1 Gene:


SOURCE GeneReport for Unigene cluster for OR10S1 Gene:

genes like me logo Genes that share expression patterns with OR10S1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10S1 Gene

Orthologs for OR10S1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10S1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466818 33
  • 99.07 (n)
(Canis familiaris)
Mammalia OR10S1 34 33
  • 86.1 (n)
(Bos Taurus)
Mammalia OR10S1 33
  • 85.43 (n)
(Mus musculus)
Mammalia Or10s1 51 Olfr982 16 34 33
  • 83.92 (n)
(Rattus norvegicus)
Mammalia Olr1337 33
  • 82.38 (n)
(Monodelphis domestica)
Mammalia OR10S1 34
  • 74 (a)
Species where no ortholog for OR10S1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10S1 Gene

Gene Tree for OR10S1 (if available)
Gene Tree for OR10S1 (if available)
Evolutionary constrained regions (ECRs) for OR10S1: view image

Paralogs for OR10S1 Gene

Paralogs for OR10S1 Gene

(443) SIMAP similar genes for OR10S1 Gene using alignment to 1 proteins:

  • O10S1_HUMAN
genes like me logo Genes that share paralogs with OR10S1: view

Variants for OR10S1 Gene

Sequence variations from dbSNP and Humsavar for OR10S1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001193742 -- 123,978,441(-) C/G upstream_transcript_variant
rs1001832785 -- 123,978,710(-) C/T upstream_transcript_variant
rs1002891773 -- 123,979,604(-) G/A upstream_transcript_variant
rs1004516753 -- 123,978,493(-) G/A upstream_transcript_variant
rs1004827669 -- 123,978,818(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10S1 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680
esv2761716 CNV loss 21179565

Variation tolerance for OR10S1 Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.80; 93.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10S1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10S1 Gene

Disorders for OR10S1 Gene

Additional Disease Information for OR10S1

No disorders were found for OR10S1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10S1 Gene

Publications for OR10S1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR10S1 Gene

Sources for OR10S1 Gene

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