Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10R2 Gene

Aliases for OR10R2 Gene

  • Olfactory Receptor Family 10 Subfamily R Member 2 2 3 5
  • Olfactory Receptor OR1-8 3 4
  • Olfactory Receptor 10R2 3 4
  • OR10R2Q 2 3
  • Olfactory Receptor, Family 10, Subfamily R, Member 2 2
  • OR10R2 5
  • OR1-8 3

External Ids for OR10R2 Gene

Previous GeneCards Identifiers for OR10R2 Gene

  • GC01U990367
  • GC01P155659
  • GC01P155250
  • GC01P156716
  • GC01P158449

Summaries for OR10R2 Gene

Entrez Gene Summary for OR10R2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10R2 Gene

OR10R2 (Olfactory Receptor Family 10 Subfamily R Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR10T2.

UniProtKB/Swiss-Prot Summary for OR10R2 Gene

Gene Wiki entry for OR10R2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10R2 Gene

Genomics for OR10R2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10R2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J158434 Enhancer 0.5 Ensembl dbSUPER 11 -39.8 -39819 6 SPI1 POLR2A piR-56883-011 OR10T2 OR10R2 OR6K2 OR10X1 CD1B SPTA1 CD1D HSALNG0007729 OR10K2
GH01J158423 Enhancer 0.4 Ensembl dbSUPER 11.1 -49.5 -49519 2.2 NANOG OR10R2 OR10T2 CD1B OR10K2 HSALNG0007729
GH01J158144 Promoter/Enhancer 1.2 EPDnew FANTOM5 ENCODE 3.4 -325.8 -325755 3.4 IKZF1 CEBPB NFE2 PRDM10 PKNOX1 MAFG TCF12 ZSCAN29 TEAD4 NFIB LINC01704 piR-31926-003 CD1D ELL2P1 KIRREL1 OR10R2 OR10X1 LOC105371460 SMIM42
GH01J158436 Enhancer 0.3 Ensembl dbSUPER 10.4 -35.9 -35919 0.2 HSALNG0007729 OR10T2 OR10R2 OR6K2 OR10X1 OR10T1P OR10K2 OR10K1
GH01J158444 Enhancer 0.2 dbSUPER 11.7 -25.8 -25787 4.2 OR10T1P OR10R2 OR10K2 OR6N2 CD1B EI24P2 OR10K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10R2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10R2

Top Transcription factor binding sites by QIAGEN in the OR10R2 gene promoter:
  • NF-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU2F1
  • POU2F1a
  • PPAR-gamma2
  • RP58

Genomic Locations for OR10R2 Gene

Latest Assembly
chr1:158,472,220-158,480,936
(GRCh38/hg38)
Size:
8,717 bases
Orientation:
Plus strand

Previous Assembly
chr1:158,449,668-158,450,675
(GRCh37/hg19 by Entrez Gene)
Size:
1,008 bases
Orientation:
Plus strand

chr1:158,449,668-158,450,675
(GRCh37/hg19 by Ensembl)
Size:
1,008 bases
Orientation:
Plus strand

Genomic View for OR10R2 Gene

Genes around OR10R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10R2 Gene

Proteins for OR10R2 Gene

  • Protein details for OR10R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGX6-O10R2_HUMAN
    Recommended name:
    Olfactory receptor 10R2
    Protein Accession:
    Q8NGX6
    Secondary Accessions:
    • Q5VWM8
    • Q6IFS1
    • Q96R61

    Protein attributes for OR10R2 Gene

    Size:
    335 amino acids
    Molecular mass:
    37486 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10R2 Gene

Post-translational modifications for OR10R2 Gene

  • Glycosylation at Asn25
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10R2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10R2 Gene

Domains & Families for OR10R2 Gene

Gene Families for OR10R2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10R2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10R2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-8 (O10R2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGX6

UniProtKB/Swiss-Prot:

O10R2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10R2: view

Function for OR10R2 Gene

Molecular function for OR10R2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10R2 Gene

Gene Ontology (GO) - Molecular Function for OR10R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR10R2: view
genes like me logo Genes that share phenotypes with OR10R2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10R2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10R2 Gene

Localization for OR10R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10R2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10R2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA 21873635
genes like me logo Genes that share ontologies with OR10R2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10R2 Gene

Pathways & Interactions for OR10R2 Gene

genes like me logo Genes that share pathways with OR10R2: view

Pathways by source for OR10R2 Gene

Interacting Proteins for OR10R2 Gene

Gene Ontology (GO) - Biological Process for OR10R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA,IBA 21873635
genes like me logo Genes that share ontologies with OR10R2: view

No data available for SIGNOR curated interactions for OR10R2 Gene

Drugs & Compounds for OR10R2 Gene

No Compound Related Data Available

Transcripts for OR10R2 Gene

mRNA/cDNA for OR10R2 Gene

1 REFSEQ mRNAs :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10R2

Alternative Splicing Database (ASD) splice patterns (SP) for OR10R2 Gene

No ASD Table

Relevant External Links for OR10R2 Gene

GeneLoc Exon Structure for
OR10R2

Expression for OR10R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10R2 Gene

Protein differential expression in normal tissues from HIPED for OR10R2 Gene

This gene is overexpressed in Esophagus (46.6) and Kidney (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10R2 Gene



Protein tissue co-expression partners for OR10R2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10R2

SOURCE GeneReport for Unigene cluster for OR10R2 Gene:

Hs.451913
genes like me logo Genes that share expression patterns with OR10R2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10R2 Gene

Orthologs for OR10R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10R2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC469527 29
  • 99.6 (n)
OR10R2 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR10R2 29 30
  • 86.6 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR10R2 30
  • 76 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 74 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Olfr1406 30
  • 55 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101734876 29
  • 56.49 (n)
Species where no ortholog for OR10R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10R2 Gene

ENSEMBL:
Gene Tree for OR10R2 (if available)
TreeFam:
Gene Tree for OR10R2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10R2: view image
Alliance of Genome Resources:
Additional Orthologs for OR10R2

Paralogs for OR10R2 Gene

(456) SIMAP similar genes for OR10R2 Gene using alignment to 1 proteins:

  • O10R2_HUMAN

Pseudogenes.org Pseudogenes for OR10R2 Gene

genes like me logo Genes that share paralogs with OR10R2: view

Variants for OR10R2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10R2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1418843 -- p.Leu239Phe
rs3820678 -- p.Ala191Thr
rs6679056 -- p.Glu216Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10R2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR10R2 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.91; 99.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10R2
Leiden Open Variation Database (LOVD)
OR10R2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR10R2 Gene

Disorders for OR10R2 Gene

Additional Disease Information for OR10R2

No disorders were found for OR10R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10R2 Gene

Publications for OR10R2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Genome-wide association of sleep and circadian phenotypes. (PMID: 17903308) Gottlieb DJ … Wilk JB (BMC medical genetics 2007) 40

Products for OR10R2 Gene

Sources for OR10R2 Gene