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Aliases for OR10P1 Gene

Aliases for OR10P1 Gene

  • Olfactory Receptor Family 10 Subfamily P Member 1 2 3 5
  • Olfactory Receptor OR12-7 3 4
  • Olfactory Receptor 10P1 3 4
  • Olfactory Receptor 10P2 3 4
  • Olfactory Receptor 10P3 3 4
  • OR10P1P 3 4
  • OR10P2P 3 4
  • OR10P3P 3 4
  • Olfactory Receptor, Family 10, Subfamily P, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 10, Subfamily P, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 10, Subfamily P, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 10, Subfamily P, Member 1 2
  • Seven Transmembrane Helix Receptor 3
  • OR12-7 3
  • OST701 3

External Ids for OR10P1 Gene

Previous HGNC Symbols for OR10P1 Gene

  • OR10P1P
  • OR10P2P
  • OR10P3P

Previous GeneCards Identifiers for OR10P1 Gene

  • GC12P054317
  • GC12P054318
  • GC12P056030

Summaries for OR10P1 Gene

Entrez Gene Summary for OR10P1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10P1 Gene

OR10P1 (Olfactory Receptor Family 10 Subfamily P Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10C1.

UniProtKB/Swiss-Prot for OR10P1 Gene

Gene Wiki entry for OR10P1 Gene

Additional gene information for OR10P1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10P1 Gene

Genomics for OR10P1 Gene

GeneHancer (GH) Regulatory Elements for OR10P1 Gene

Promoters and enhancers for OR10P1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055635 Enhancer 0.2 dbSUPER 607.2 +0.3 319 3.7 OR10P1 OR10AE3P ENSG00000258921 OR6C70
GH12J055880 Enhancer 0.8 FANTOM5 Ensembl ENCODE 18.8 +244.1 244081 1.1 NR2F1 ATF2 GC12P055881 OR10P1 OR6C4 MMP19 ORMDL2 SARNP CDK2 PMEL RAB5B OR6C65
GH12J055702 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 5.2 +71.6 71587 11.7 ZNF148 CEBPG RERE NFIB ZSCAN21 ZBTB7A SP7 SP1 SP5 KLF14 ITGA7 BLOC1S1 RN7SL809P RPL41 RBMS2 METTL7B BAZ2A CD63 GDF11 RNU6-343P
GH12J056040 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.1 +405.1 405139 3.3 MTA3 SP1 ELF3 ZFX CTCF ZKSCAN8 MNT SIX5 ZNF148 NKRF RPS26 LOC105369780 ENSG00000257449 BAZ2A RN7SL809P CDK2 ZC3H10 STAT2 RNU6-343P PAN2
GH12J055645 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 6.1 +9.8 9790 1.8 HDGF ZFX ZNF148 ZNF121 GTF2F1 CTCF YY1 TRIM24 SP7 SP1 OR10AE3P SMARCC2 ANKRD52 PHC1P1 DNAJC14 IKZF4 PAN2 TMEM198B IL23A ENSG00000257740
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10P1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10P1 gene promoter:
  • AML1a
  • AREB6
  • Evi-1
  • HNF-4alpha1
  • HSF1 (long)
  • HSF1short
  • Nkx2-2
  • SEF-1 (1)
  • SREBP-1a
  • SREBP-1b

Genomic Locations for OR10P1 Gene

Genomic Locations for OR10P1 Gene
chr12:55,636,860-55,637,854
(GRCh38/hg38)
Size:
995 bases
Orientation:
Plus strand
chr12:56,030,644-56,031,638
(GRCh37/hg19)
Size:
995 bases
Orientation:
Plus strand

Genomic View for OR10P1 Gene

Genes around OR10P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10P1 Gene

Proteins for OR10P1 Gene

  • Protein details for OR10P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE3-O10P1_HUMAN
    Recommended name:
    Olfactory receptor 10P1
    Protein Accession:
    Q8NGE3
    Secondary Accessions:
    • B9EGY4

    Protein attributes for OR10P1 Gene

    Size:
    313 amino acids
    Molecular mass:
    34741 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10P1 Gene

Post-translational modifications for OR10P1 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10P1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10P1 Gene

Domains & Families for OR10P1 Gene

Gene Families for OR10P1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10P1 Gene

Suggested Antigen Peptide Sequences for OR10P1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR12-7 (O10P1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGE3

UniProtKB/Swiss-Prot:

O10P1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10P1: view

Function for OR10P1 Gene

Molecular function for OR10P1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10P1 Gene

Gene Ontology (GO) - Molecular Function for OR10P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10P1: view
genes like me logo Genes that share phenotypes with OR10P1: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR10P1 - Now 50% OFF >
  • * OR10P1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR10P1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10P1 Gene

Localization for OR10P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10P1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10P1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10P1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10P1 Gene

Pathways & Interactions for OR10P1 Gene

genes like me logo Genes that share pathways with OR10P1: view

Pathways by source for OR10P1 Gene

Interacting Proteins for OR10P1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000308082%0d9606.ENSP00000233596%0d9606.ENSP00000248572%0d9606.ENSP00000259030%0d9606.ENSP00000296142%0d9606.ENSP00000303482%0d
Selected Interacting proteins: ENSP00000308082 Q8NGE3-O10P1_HUMAN for OR10P1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR10P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10P1: view

No data available for SIGNOR curated interactions for OR10P1 Gene

Drugs & Compounds for OR10P1 Gene

No Compound Related Data Available

Transcripts for OR10P1 Gene

mRNA/cDNA for OR10P1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OR10P1 Gene

Olfactory receptor, family 10, subfamily P, member 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR10P1 - Now 50% OFF >
  • * OR10P1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR10P1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for OR10P1 Gene

No ASD Table

Relevant External Links for OR10P1 Gene

GeneLoc Exon Structure for
OR10P1
ECgene alternative splicing isoforms for
OR10P1

Expression for OR10P1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10P1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR10P1 Gene

This gene is overexpressed in Heart - Atrial Appendage (x40.4).

NURSA nuclear receptor signaling pathways regulating expression of OR10P1 Gene:

OR10P1

SOURCE GeneReport for Unigene cluster for OR10P1 Gene:

Hs.554551
genes like me logo Genes that share expression patterns with OR10P1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10P1 Gene

Orthologs for OR10P1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10P1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR10P1 35 34
  • 87.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Or10p1 51 Olfr796 17 35 34
  • 82.9 (n)
Or10p21 51 Olfr763
  • chr10:129,011,287-129,012,213
Or10p22 51 Olfr9
  • chr10:128,989,914-128,990,849
rat
(Rattus norvegicus)
Mammalia Olr1016 34
  • 80.87 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia OR10P1 35
  • 48 (a)
OneToOne
Species where no ortholog for OR10P1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10P1 Gene

ENSEMBL:
Gene Tree for OR10P1 (if available)
TreeFam:
Gene Tree for OR10P1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10P1: view image

Paralogs for OR10P1 Gene

(450) SIMAP similar genes for OR10P1 Gene using alignment to 1 proteins:

  • O10P1_HUMAN
genes like me logo Genes that share paralogs with OR10P1: view

Variants for OR10P1 Gene

Sequence variations from dbSNP and Humsavar for OR10P1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000076142 -- 55,635,803(+) A/T upstream_transcript_variant
rs1000126683 -- 55,635,492(+) C/A upstream_transcript_variant
rs1001937327 -- 55,636,606(+) A/G upstream_transcript_variant
rs1003925264 -- 55,636,186(+) C/T upstream_transcript_variant
rs1003989581 -- 55,636,742(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10P1 Gene

Variant ID Type Subtype PubMed ID
nsv559001 CNV loss 21841781

Variation tolerance for OR10P1 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.80; 79.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10P1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10P1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10P1 Gene

Disorders for OR10P1 Gene

Additional Disease Information for OR10P1

No disorders were found for OR10P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10P1 Gene

Publications for OR10P1 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for OR10P1 Gene

Sources for OR10P1 Gene

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