OR10P1 Gene (Protein Coding)

Olfactory Receptor Family 10 Subfamily P Member 1

GC12P055636
GIFtS:
30
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10P1 Gene

Aliases for OR10P1 Gene

  • Olfactory Receptor Family 10 Subfamily P Member 1 2 3 5
  • Olfactory Receptor OR12-7 3 4
  • Olfactory Receptor 10P1 3 4
  • Olfactory Receptor 10P2 3 4
  • Olfactory Receptor 10P3 3 4
  • OR10P1P 3 4
  • OR10P2P 3 4
  • OR10P3P 3 4
  • OST701 2 3
  • Olfactory Receptor, Family 10, Subfamily P, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 10, Subfamily P, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 10, Subfamily P, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 10, Subfamily P, Member 1 2
  • Seven Transmembrane Helix Receptor 3
  • OR12-7 3
  • OR10P1 5

External Ids for OR10P1 Gene

Previous HGNC Symbols for OR10P1 Gene

  • OR10P1P
  • OR10P2P
  • OR10P3P

Previous GeneCards Identifiers for OR10P1 Gene

  • GC12P054317
  • GC12P054318
  • GC12P056030

Summaries for OR10P1 Gene

Entrez Gene Summary for OR10P1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10P1 Gene

OR10P1 (Olfactory Receptor Family 10 Subfamily P Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10C1.

UniProtKB/Swiss-Prot Summary for OR10P1 Gene

Gene Wiki entry for OR10P1 Gene

Additional gene information for OR10P1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10P1 Gene

Genomics for OR10P1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR10P1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10P1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10P1

Top Transcription factor binding sites by QIAGEN in the OR10P1 gene promoter:
  • AML1a
  • AREB6
  • Evi-1
  • HNF-4alpha1
  • HSF1 (long)
  • HSF1short
  • Nkx2-2
  • SEF-1 (1)
  • SREBP-1a
  • SREBP-1b

Genomic Locations for OR10P1 Gene

Latest Assembly
chr12:55,636,860-55,637,854
(GRCh38/hg38)
Size:
995 bases
Orientation:
Plus strand

Previous Assembly
chr12:56,030,676-56,031,617
(GRCh37/hg19 by Entrez Gene)
Size:
942 bases
Orientation:
Plus strand

chr12:56,030,644-56,031,638
(GRCh37/hg19 by Ensembl)
Size:
995 bases
Orientation:
Plus strand

Genomic View for OR10P1 Gene

Genes around OR10P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10P1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR10P1 Gene

Proteins for OR10P1 Gene

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  2. Protein products for research
  3. Assay products for research

  • Protein details for OR10P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE3-O10P1_HUMAN
    Recommended name:
    Olfactory receptor 10P1
    Protein Accession:
    Q8NGE3
    Secondary Accessions:
    • B9EGY4

    Protein attributes for OR10P1 Gene

    Size:
    313 amino acids
    Molecular mass:
    34741 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10P1 Gene

Post-translational modifications for OR10P1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10P1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10P1 Gene

Domains & Families for OR10P1 Gene

Gene Families for OR10P1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10P1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10P1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR12-7 (O10P1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGE3

UniProtKB/Swiss-Prot:

O10P1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10P1: view

Function for OR10P1 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for OR10P1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10P1 Gene

Gene Ontology (GO) - Molecular Function for OR10P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10P1: view

Phenotypes for OR10P1 Gene

GenomeRNAi human phenotypes for OR10P1:
genes like me logo Genes that share phenotypes with OR10P1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10P1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10P1 Gene

Localization for OR10P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10P1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10P1 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OR10P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10P1: view

Pathways & Interactions for OR10P1 Gene

genes like me logo Genes that share pathways with OR10P1: view

Pathways by source for OR10P1 Gene

1 KEGG pathway for OR10P1 Gene

Interacting Proteins for OR10P1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000308082 Q8NGE3-O10P1_HUMAN for OR10P1 Gene via STRING IID

GPS-Prot Interaction Network for OR10P1

Gene Ontology (GO) - Biological Process for OR10P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10P1: view

No data available for SIGNOR curated interactions for OR10P1 Gene

Drugs & Compounds for OR10P1 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for OR10P1 Gene

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mRNA/cDNA for OR10P1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10P1

Alternative Splicing Database (ASD) splice patterns (SP) for OR10P1 Gene

No ASD Table

Relevant External Links for OR10P1 Gene

GeneLoc Exon Structure for
OR10P1

Expression for OR10P1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10P1 Gene

mRNA expression in normal human tissues for OR10P1 Gene
mRNA expression by GTEx for OR10P1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR10P1 Gene

This gene is overexpressed in Heart - Atrial Appendage (x40.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10P1

SOURCE GeneReport for Unigene cluster for OR10P1 Gene:

Hs.554551
genes like me logo Genes that share expression patterns with OR10P1: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10P1 Gene

Orthologs for OR10P1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10P1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
 Mammalia OR10P1 29 30
  • 87.18 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Or10p1 45 Olfr796 29 16 30
  • 82.9 (n)
 OneToOne
Or10p21 45 Olfr763
  • chr10:129,011,287-129,012,213
Or10p22 45 Olfr9
  • chr10:128,989,914-128,990,849
Rat
(Rattus norvegicus)
 Mammalia Olr1016 29
  • 80.87 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 57 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia OR10P1 30
  • 48 (a)
 OneToOne
Species where no ortholog for OR10P1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10P1 Gene

ENSEMBL:
Gene Tree for OR10P1 (if available)
TreeFam:
Gene Tree for OR10P1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10P1: view image
Alliance of Genome Resources:
Additional Orthologs for OR10P1

Paralogs for OR10P1 Gene

Paralogs for OR10P1 Gene

(450) SIMAP similar genes for OR10P1 Gene using alignment to 1 proteins:

  • O10P1_HUMAN
genes like me logo Genes that share paralogs with OR10P1: view

Variants for OR10P1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10P1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs113745484 Benign: not provided 55,637,676(+) G/A
NM_206899.1(OR10P1):c.785G>A (p.Arg262Gln) 		MISSENSE
rs7305623 Benign: not provided 55,637,137(+) G/A
NM_206899.1(OR10P1):c.246G>A (p.Leu82=) 		SYNONYMOUS
rs76940436 Benign: not provided 55,637,534(+) A/T
NM_206899.1(OR10P1):c.643A>T (p.Ile215Phe) 		MISSENSE
rs77750365 Benign: not provided 55,637,554(+) C/T
NM_206899.1(OR10P1):c.663C>T (p.Arg221=) 		SYNONYMOUS
rs78001418 Benign: not provided 55,637,086(+) A/G
NM_206899.1(OR10P1):c.195A>G (p.Gln65=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10P1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR10P1 Gene

Variant ID Type Subtype PubMed ID
nsv559001 CNV loss 21841781

Variation tolerance for OR10P1 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.80; 79.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10P1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10P1
Leiden Open Variation Database (LOVD)
OR10P1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10P1 Gene

Disorders for OR10P1 Gene

Additional Disease Information for OR10P1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR10P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10P1 Gene

Publications for OR10P1 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

ExternalLinks

View latest publications for OR10P1 gene in Mastermind

Products for OR10P1 Gene

Sources for OR10P1 Gene