Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10K2 Gene

Aliases for OR10K2 Gene

  • Olfactory Receptor Family 10 Subfamily K Member 2 2 3 5
  • Olfactory Receptor OR1-4 3 4
  • Olfactory Receptor 10K2 3 4
  • Olfactory Receptor, Family 10, Subfamily K, Member 2 2
  • OR10K2 5
  • OR1-4 3

External Ids for OR10K2 Gene

Previous GeneCards Identifiers for OR10K2 Gene

  • GC01U990365
  • GC01M155606
  • GC01P155248
  • GC01M155203
  • GC01M156657
  • GC01M158388

Summaries for OR10K2 Gene

Entrez Gene Summary for OR10K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10K2 Gene

OR10K2 (Olfactory Receptor Family 10 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR10K1.

UniProtKB/Swiss-Prot Summary for OR10K2 Gene

Gene Wiki entry for OR10K2 Gene

Additional gene information for OR10K2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10K2 Gene

Genomics for OR10K2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10K2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J158426 Enhancer 0.3 Ensembl dbSUPER 600.7 +0.9 936 1 OR10K2 CD1B OR10T2
GH01J158424 Enhancer 0.2 dbSUPER 600.7 +1.9 1887 0.6 OR10K2 CD1B OR10T2
GH01J158361 Enhancer 0.3 dbSUPER 10.2 +62.2 62165 4.2 FOXA2 CD1B OR10T2 CD1C OR10K2 OR10X1 CD1E HSALNG0007728 piR-33303-007
GH01J158374 Enhancer 0.3 Ensembl 9.9 +51.4 51436 0.8 SPI1 piR-33303-007 piR-39098-011 piR-58297-028 OR10T2 OR10K2 CD1B ACKR1 piR-56341-006 CD1E
GH01J158366 Enhancer 0.3 dbSUPER 9.9 +59.4 59419 0.8 TBX21 OR10T2 OR10K2 OR10X1 piR-33303-007 HSALNG0007728 CD1E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10K2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10K2

Top Transcription factor binding sites by QIAGEN in the OR10K2 gene promoter:
  • AREB6
  • ATF
  • Cart-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • S8

Genomic Locations for OR10K2 Gene

Genomic Locations for OR10K2 Gene
chr1:158,418,210-158,426,237
(GRCh38/hg38)
Size:
8,028 bases
Orientation:
Minus strand
chr1:158,389,718-158,390,656
(GRCh37/hg19)
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR10K2 Gene

Genes around OR10K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10K2 Gene

Proteins for OR10K2 Gene

  • Protein details for OR10K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IF99-O10K2_HUMAN
    Recommended name:
    Olfactory receptor 10K2
    Protein Accession:
    Q6IF99

    Protein attributes for OR10K2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35029 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10K2 Gene

Post-translational modifications for OR10K2 Gene

  • Glycosylation at Asn5 and Asn265

Other Protein References for OR10K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10K2 Gene

Domains & Families for OR10K2 Gene

Gene Families for OR10K2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10K2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR10K2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-4 (O10K2_HUMAN)
  • Seven transmembrane helix receptor (Q8NGX4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IF99

UniProtKB/Swiss-Prot:

O10K2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10K2: view

Function for OR10K2 Gene

Molecular function for OR10K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10K2 Gene

Gene Ontology (GO) - Molecular Function for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10K2: view
genes like me logo Genes that share phenotypes with OR10K2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10K2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10K2 Gene

Localization for OR10K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10K2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10K2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10K2 Gene

Pathways & Interactions for OR10K2 Gene

genes like me logo Genes that share pathways with OR10K2: view

Pathways by source for OR10K2 Gene

Interacting Proteins for OR10K2 Gene

Gene Ontology (GO) - Biological Process for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10K2: view

No data available for SIGNOR curated interactions for OR10K2 Gene

Drugs & Compounds for OR10K2 Gene

No Compound Related Data Available

Transcripts for OR10K2 Gene

mRNA/cDNA for OR10K2 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10K2

Alternative Splicing Database (ASD) splice patterns (SP) for OR10K2 Gene

No ASD Table

Relevant External Links for OR10K2 Gene

GeneLoc Exon Structure for
OR10K2

Expression for OR10K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10K2 Gene

Protein differential expression in normal tissues from HIPED for OR10K2 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10K2 Gene



Protein tissue co-expression partners for OR10K2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10K2

SOURCE GeneReport for Unigene cluster for OR10K2 Gene:

Hs.626815
genes like me logo Genes that share expression patterns with OR10K2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10K2 Gene

Orthologs for OR10K2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10K2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR10K2 31
  • 99 (a)
OneToOne
LOC100615080 30
  • 98.59 (n)
Cow
(Bos Taurus)
Mammalia OR10K2 30 31
  • 86.26 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OR10K2 31
  • 82 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1667 30
  • 80.92 (n)
Mouse
(Mus musculus)
Mammalia Or10k2 46 Olfr370 30 17 31
  • 80.6 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 59 (a)
ManyToMany
-- 31
  • 59 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 49 (a)
ManyToMany
Species where no ortholog for OR10K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10K2 Gene

ENSEMBL:
Gene Tree for OR10K2 (if available)
TreeFam:
Gene Tree for OR10K2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10K2: view image

Paralogs for OR10K2 Gene

(441) SIMAP similar genes for OR10K2 Gene using alignment to 2 proteins:

  • O10K2_HUMAN
  • Q8NGX4_HUMAN
genes like me logo Genes that share paralogs with OR10K2: view

Variants for OR10K2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10K2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs386352340 Uncertain Significance: not provided 158,420,710(-) T/C MISSENSE_VARIANT
rs12240099 - p.Ala208Thr

Additional dbSNP identifiers (rs#s) for OR10K2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR10K2 Gene

Variant ID Type Subtype PubMed ID
nsv831692 CNV gain 17160897

Variation tolerance for OR10K2 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10K2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10K2 Gene

Disorders for OR10K2 Gene

No disorders were found for OR10K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10K2 Gene

Publications for OR10K2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10K2 Gene

Sources for OR10K2 Gene