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Aliases for OR10K2 Gene

Aliases for OR10K2 Gene

  • Olfactory Receptor Family 10 Subfamily K Member 2 2 3 5
  • Olfactory Receptor OR1-4 3 4
  • Olfactory Receptor, Family 10, Subfamily K, Member 2 2
  • Olfactory Receptor 10K2 3
  • OR1-4 3

External Ids for OR10K2 Gene

Previous GeneCards Identifiers for OR10K2 Gene

  • GC01U990365
  • GC01M155606
  • GC01P155248
  • GC01M155203
  • GC01M156657

Summaries for OR10K2 Gene

Entrez Gene Summary for OR10K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10K2 Gene

OR10K2 (Olfactory Receptor Family 10 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR10K1.

UniProtKB/Swiss-Prot for OR10K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR10K2 Gene

Additional gene information for OR10K2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10K2 Gene

Genomics for OR10K2 Gene

GeneHancer (GH) Regulatory Elements for OR10K2 Gene

Promoters and enhancers for OR10K2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J158425 Enhancer 0.2 dbSUPER 650.7 +0.0 5 0.9 OR10K2 CD1E OR10T2 CD1B
GH01J158424 Enhancer 0.2 dbSUPER 650.7 +1.9 1887 0.6 OR10K2 CD1B OR10T2
GH01J158426 Enhancer 0.2 dbSUPER 650.7 +1.0 1035 1.1 OR10K2 CD1B OR10T2
GH01J158361 Enhancer 0.3 dbSUPER 10.2 +62.2 62165 4.2 FOXA2 CD1B OR10T2 CD1C OR10K2 OR10X1 CD1E
GH01J158444 Enhancer 0.2 dbSUPER 10.6 -20.2 -20196 4.2 OR10T1P OR10R2 OR10K2 OR6N2 CD1B EI24P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10K2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10K2 gene promoter:
  • AREB6
  • ATF
  • S8
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Cart-1

Genomic Locations for OR10K2 Gene

Genomic Locations for OR10K2 Gene
chr1:158,418,210-158,426,237
(GRCh38/hg38)
Size:
8,028 bases
Orientation:
Minus strand
chr1:158,389,718-158,390,656
(GRCh37/hg19)
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR10K2 Gene

Genes around OR10K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10K2 Gene

Proteins for OR10K2 Gene

  • Protein details for OR10K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IF99-O10K2_HUMAN
    Recommended name:
    Olfactory receptor 10K2
    Protein Accession:
    Q6IF99

    Protein attributes for OR10K2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35029 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10K2 Gene

Post-translational modifications for OR10K2 Gene

Other Protein References for OR10K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10K2 Gene

Domains & Families for OR10K2 Gene

Gene Families for OR10K2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10K2 Gene

Suggested Antigen Peptide Sequences for OR10K2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6IF99

UniProtKB/Swiss-Prot:

O10K2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10K2: view

Function for OR10K2 Gene

Molecular function for OR10K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10K2 Gene

Gene Ontology (GO) - Molecular Function for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10K2: view
genes like me logo Genes that share phenotypes with OR10K2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10K2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10K2 Gene

Localization for OR10K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10K2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10K2 Gene

Pathways & Interactions for OR10K2 Gene

genes like me logo Genes that share pathways with OR10K2: view

Pathways by source for OR10K2 Gene

Interacting Proteins for OR10K2 Gene

Gene Ontology (GO) - Biological Process for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR10K2: view

No data available for SIGNOR curated interactions for OR10K2 Gene

Drugs & Compounds for OR10K2 Gene

No Compound Related Data Available

Transcripts for OR10K2 Gene

mRNA/cDNA for OR10K2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10K2 Gene

Olfactory receptor, family 10, subfamily K, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10K2

Alternative Splicing Database (ASD) splice patterns (SP) for OR10K2 Gene

No ASD Table

Relevant External Links for OR10K2 Gene

GeneLoc Exon Structure for
OR10K2
ECgene alternative splicing isoforms for
OR10K2

Expression for OR10K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10K2 Gene

Protein differential expression in normal tissues from HIPED for OR10K2 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10K2 Gene



Protein tissue co-expression partners for OR10K2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10K2 Gene:

OR10K2

SOURCE GeneReport for Unigene cluster for OR10K2 Gene:

Hs.626815
genes like me logo Genes that share expression patterns with OR10K2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10K2 Gene

Orthologs for OR10K2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10K2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR10K2 34
  • 99 (a)
OneToOne
LOC100615080 33
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia OR10K2 34 33
  • 86.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OR10K2 34
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1667 33
  • 80.92 (n)
mouse
(Mus musculus)
Mammalia Or10k2 51 Olfr370 16 34 33
  • 80.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
ManyToMany
-- 34
  • 59 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
ManyToMany
Species where no ortholog for OR10K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10K2 Gene

ENSEMBL:
Gene Tree for OR10K2 (if available)
TreeFam:
Gene Tree for OR10K2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10K2: view image

Paralogs for OR10K2 Gene

(441) SIMAP similar genes for OR10K2 Gene using alignment to 2 proteins:

  • O10K2_HUMAN
  • Q8NGX4_HUMAN
genes like me logo Genes that share paralogs with OR10K2: view

Variants for OR10K2 Gene

Sequence variations from dbSNP and Humsavar for OR10K2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs386352340 uncertain-significance, not provided 158,420,710(-) T/C coding_sequence_variant, missense_variant
rs1001195029 -- 158,419,702(-) C/T downstream_transcript_variant
rs1002487966 -- 158,422,036(-) T/C upstream_transcript_variant
rs1005845727 -- 158,421,627(-) C/T upstream_transcript_variant
rs1006806542 -- 158,422,756(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10K2 Gene

Variant ID Type Subtype PubMed ID
nsv831692 CNV gain 17160897

Variation tolerance for OR10K2 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10K2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10K2 Gene

Disorders for OR10K2 Gene

Additional Disease Information for OR10K2

No disorders were found for OR10K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10K2 Gene

Publications for OR10K2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10K2 Gene

Sources for OR10K2 Gene

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