Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10K1 Gene

Aliases for OR10K1 Gene

  • Olfactory Receptor Family 10 Subfamily K Member 1 2 3 5
  • Olfactory Receptor OR1-6 3 4
  • Olfactory Receptor 10K1 3 4
  • Olfactory Receptor, Family 10, Subfamily K, Member 1 2
  • OR10K1 5
  • OR1-6 3

External Ids for OR10K1 Gene

Previous GeneCards Identifiers for OR10K1 Gene

  • GC01U990362
  • GC01P155653
  • GC01P155249
  • GC01P156701
  • GC01P158435

Summaries for OR10K1 Gene

Entrez Gene Summary for OR10K1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10K1 Gene

OR10K1 (Olfactory Receptor Family 10 Subfamily K Member 1) is a Protein Coding gene. Diseases associated with OR10K1 include Liver Angiosarcoma. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR10K2.

UniProtKB/Swiss-Prot Summary for OR10K1 Gene

Gene Wiki entry for OR10K1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10K1 Gene

Genomics for OR10K1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10K1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J158689 Enhancer 1.1 FANTOM5 Ensembl dbSUPER 1.4 +229.2 229227 4.4 NCOR1 NFIC TAL1 NUFIP1 STAT5A THRAP3 SMARCA4 FOXM1 HDAC2 TCF12 SPTA1 OR6K4P OR6N1 OR6K3 OR10K1 OR10Z1 OR6K1P OR6K2
GH01J158400 Enhancer 0.4 FANTOM5 dbSUPER 1.7 -60.5 -60549 0.3 OR10T2 CD1E CD1B OR10K1 OR6K3 OR6N1 OR10K2
GH01J158434 Enhancer 0.5 Ensembl dbSUPER 0.3 -29.2 -29173 6 SPI1 POLR2A piR-56883-011 OR10T2 OR10R2 OR6K2 OR10X1 CD1B SPTA1 CD1D HSALNG0007729 OR10K2
GH01J158457 Enhancer 0.2 Ensembl 0.7 -4.3 -4273 0.2 OR10K1 lnc-OR10K1-1 OR10K2
GH01J158436 Enhancer 0.3 Ensembl dbSUPER 0.3 -25.3 -25273 0.2 HSALNG0007729 OR10T2 OR10R2 OR6K2 OR10X1 OR10T1P OR10K2 OR10K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10K1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10K1

Top Transcription factor binding sites by QIAGEN in the OR10K1 gene promoter:
  • NF-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • p53
  • Pax-6
  • POU2F1
  • POU2F1a
  • RP58

Genomic Locations for OR10K1 Gene

Latest Assembly
chr1:158,461,574-158,470,857
(GRCh38/hg38)
Size:
9,284 bases
Orientation:
Plus strand

Previous Assembly
chr1:158,431,624-158,437,248
(GRCh37/hg19 by Entrez Gene)
Size:
5,625 bases
Orientation:
Plus strand

chr1:158,435,272-158,436,344
(GRCh37/hg19 by Ensembl)
Size:
1,073 bases
Orientation:
Plus strand

Genomic View for OR10K1 Gene

Genes around OR10K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10K1 Gene

Proteins for OR10K1 Gene

  • Protein details for OR10K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGX5-O10K1_HUMAN
    Recommended name:
    Olfactory receptor 10K1
    Protein Accession:
    Q8NGX5
    Secondary Accessions:
    • Q6IFS2

    Protein attributes for OR10K1 Gene

    Size:
    313 amino acids
    Molecular mass:
    35079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10K1 Gene

Post-translational modifications for OR10K1 Gene

  • Glycosylation at Asn5 and Asn265
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10K1 Gene

No data available for DME Specific Peptides for OR10K1 Gene

Domains & Families for OR10K1 Gene

Gene Families for OR10K1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10K1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10K1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-6 (O10K1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGX5

UniProtKB/Swiss-Prot:

O10K1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10K1: view

Function for OR10K1 Gene

Molecular function for OR10K1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10K1 Gene

Gene Ontology (GO) - Molecular Function for OR10K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR10K1: view
genes like me logo Genes that share phenotypes with OR10K1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10K1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10K1 Gene

Localization for OR10K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10K1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10K1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with OR10K1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10K1 Gene

Pathways & Interactions for OR10K1 Gene

genes like me logo Genes that share pathways with OR10K1: view

Pathways by source for OR10K1 Gene

Interacting Proteins for OR10K1 Gene

Gene Ontology (GO) - Biological Process for OR10K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA 21873635
genes like me logo Genes that share ontologies with OR10K1: view

No data available for SIGNOR curated interactions for OR10K1 Gene

Drugs & Compounds for OR10K1 Gene

No Compound Related Data Available

Transcripts for OR10K1 Gene

mRNA/cDNA for OR10K1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10K1

Alternative Splicing Database (ASD) splice patterns (SP) for OR10K1 Gene

No ASD Table

Relevant External Links for OR10K1 Gene

GeneLoc Exon Structure for
OR10K1

Expression for OR10K1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10K1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10K1

SOURCE GeneReport for Unigene cluster for OR10K1 Gene:

Hs.690410
genes like me logo Genes that share expression patterns with OR10K1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10K1 Gene

Orthologs for OR10K1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10K1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC744183 29
  • 98.62 (n)
OR10K1 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR10K1 29 30
  • 87.22 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC488612 29
  • 84.67 (n)
OR10K1 30
  • 83 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR10K1 30
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 60 (a)
ManyToMany
-- 30
  • 60 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr479 30
  • 45 (a)
ManyToMany
Species where no ortholog for OR10K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10K1 Gene

ENSEMBL:
Gene Tree for OR10K1 (if available)
TreeFam:
Gene Tree for OR10K1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10K1: view image
Alliance of Genome Resources:
Additional Orthologs for OR10K1

Paralogs for OR10K1 Gene

(440) SIMAP similar genes for OR10K1 Gene using alignment to 1 proteins:

  • O10K1_HUMAN
genes like me logo Genes that share paralogs with OR10K1: view

Variants for OR10K1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10K1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR10K1 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10K1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10K1
Leiden Open Variation Database (LOVD)
OR10K1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for OR10K1 Gene

Disorders for OR10K1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR10K1 Gene - From: COP

Disorder Aliases PubMed IDs
liver angiosarcoma
  • angiosarcoma of liver
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR10K1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OR10K1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR10K1 Gene

Publications for OR10K1 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 40
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR10K1 Gene

Sources for OR10K1 Gene