Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10J5 Gene

Aliases for OR10J5 Gene

  • Olfactory Receptor Family 10 Subfamily J Member 5 2 3 5
  • Olfactory Receptor OR1-28 3 4
  • Olfactory Receptor 10J5 3 4
  • Olfactory Receptor, Family 10, Subfamily J, Member 5 2
  • OR1-28 3
  • OR10J5 5

External Ids for OR10J5 Gene

Previous GeneCards Identifiers for OR10J5 Gene

  • GC01U990424
  • GC01M156722
  • GC01M156317
  • GC01M157771
  • GC01M157516

Summaries for OR10J5 Gene

Entrez Gene Summary for OR10J5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10J5 Gene

OR10J5 (Olfactory Receptor Family 10 Subfamily J Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10J1.

UniProtKB/Swiss-Prot Summary for OR10J5 Gene

Gene Wiki entry for OR10J5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10J5 Gene

Genomics for OR10J5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10J5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159594 Enhancer 0.8 Ensembl ENCODE 10.6 -60.8 -60760 5.1 YY1 CEBPB EP300 FOXA2 RAD21 ZBTB33 STAT3 JUND HNF4A FOXA1 OR10J6P OR10J5 OR10J3 DUSP23 SLAMF9 APCS HSALNG0007773 CRP
GH01J159509 Enhancer 0.6 ENCODE 11 +26.2 26224 1.5 ATF3 YY1 CEBPB RXRA HNF4A ATF4 REST SP1 TRIM24 HNF4G HSALNG0007771 OR10J5 piR-58297-029 HSALNG0007770 OR10J4
GH01J159141 Enhancer 0.5 FANTOM5 7.9 +393.8 393842 0.4 ZBTB48 TCF7L2 SP1 ZBTB17 PRDM10 POLR2A TRR-TCT4-1 OR6K3 OR6N1 FCER1A OR6N2 OR10J5 OR10J1 CADM3 AIM2 PYDC5
GH01J159171 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.2 +363.6 363606 2.8 ZIC2 SIN3A PRDM10 EGR1 SP1 EZH2 ZNF143 POLR2A CADM3 ACKR1 AIM2 CADM3-AS1 ENSG00000212161 OR10J3 OR6N1 OR6K3 FCER1A OR6N2
GH01J159682 Enhancer 0.2 FANTOM5 6.7 -146.9 -146932 0.2 FCER1A CRP OR10J5 OR10J1 CRPP1 lnc-CRP-1 ENSG00000276632 HSALNG0007779 APCS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10J5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10J5

Top Transcription factor binding sites by QIAGEN in the OR10J5 gene promoter:
  • AML1a
  • C/EBPalpha
  • C/EBPbeta
  • HSF1 (long)
  • HSF1short
  • NF-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Pax-3

Genomic Locations for OR10J5 Gene

Latest Assembly
chr1:159,535,078-159,536,007
(GRCh38/hg38)
Size:
930 bases
Orientation:
Minus strand

Previous Assembly
chr1:159,504,868-159,505,797
(GRCh37/hg19 by Entrez Gene)
Size:
930 bases
Orientation:
Minus strand

chr1:159,504,793-159,505,842
(GRCh37/hg19 by Ensembl)
Size:
1,050 bases
Orientation:
Minus strand

Genomic View for OR10J5 Gene

Genes around OR10J5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10J5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10J5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10J5 Gene

Proteins for OR10J5 Gene

  • Protein details for OR10J5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHC4-O10J5_HUMAN
    Recommended name:
    Olfactory receptor 10J5
    Protein Accession:
    Q8NHC4
    Secondary Accessions:
    • B9EH35
    • Q6IFH2

    Protein attributes for OR10J5 Gene

    Size:
    309 amino acids
    Molecular mass:
    34401 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10J5 Gene

Post-translational modifications for OR10J5 Gene

  • Glycosylation at Asn5

Other Protein References for OR10J5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10J5 Gene

Domains & Families for OR10J5 Gene

Gene Families for OR10J5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10J5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10J5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-28 (O10J5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHC4

UniProtKB/Swiss-Prot:

O10J5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10J5: view

Function for OR10J5 Gene

Molecular function for OR10J5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10J5 Gene

Gene Ontology (GO) - Molecular Function for OR10J5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10J5: view
genes like me logo Genes that share phenotypes with OR10J5: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10J5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10J5 Gene

Localization for OR10J5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10J5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10J5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10J5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with OR10J5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10J5 Gene

Pathways & Interactions for OR10J5 Gene

genes like me logo Genes that share pathways with OR10J5: view

Pathways by source for OR10J5 Gene

Interacting Proteins for OR10J5 Gene

Gene Ontology (GO) - Biological Process for OR10J5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10J5: view

No data available for SIGNOR curated interactions for OR10J5 Gene

Drugs & Compounds for OR10J5 Gene

No Compound Related Data Available

Transcripts for OR10J5 Gene

mRNA/cDNA for OR10J5 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10J5

Alternative Splicing Database (ASD) splice patterns (SP) for OR10J5 Gene

No ASD Table

Relevant External Links for OR10J5 Gene

GeneLoc Exon Structure for
OR10J5

Expression for OR10J5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10J5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10J5

SOURCE GeneReport for Unigene cluster for OR10J5 Gene:

Hs.553587
genes like me logo Genes that share expression patterns with OR10J5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10J5 Gene

Orthologs for OR10J5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10J5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC469542 29
  • 99.24 (n)
OR10J5 30
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or10j5 45 Olfr16 29 16 30
  • 85.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1576 29
  • 85.01 (n)
Cow
(Bos Taurus)
Mammalia OR10J5 29 30
  • 84.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OR10J5 29 30
  • 83.77 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 47 (a)
ManyToMany
Species where no ortholog for OR10J5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10J5 Gene

ENSEMBL:
Gene Tree for OR10J5 (if available)
TreeFam:
Gene Tree for OR10J5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10J5: view image
Alliance of Genome Resources:
Additional Orthologs for OR10J5

Paralogs for OR10J5 Gene

(452) SIMAP similar genes for OR10J5 Gene using alignment to 1 proteins:

  • O10J5_HUMAN

Pseudogenes.org Pseudogenes for OR10J5 Gene

genes like me logo Genes that share paralogs with OR10J5: view

Variants for OR10J5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10J5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs56786307 Benign: not provided 159,535,412(-) T/A
NM_001004469.1(OR10J5):c.596A>T (p.Tyr199Phe)
MISSENSE
rs35393723 -- p.Arg233Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10J5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR10J5 Gene

Variant ID Type Subtype PubMed ID
esv3578214 CNV loss 25503493
nsv1005195 CNV gain 25217958

Variation tolerance for OR10J5 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10J5 Gene

Human Gene Mutation Database (HGMD)
OR10J5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10J5
Leiden Open Variation Database (LOVD)
OR10J5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10J5 Gene

Disorders for OR10J5 Gene

Additional Disease Information for OR10J5

No disorders were found for OR10J5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10J5 Gene

Publications for OR10J5 Gene

  1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q … O'Donnell CJ (BMC medical genetics 2007) 3 40
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Expression of human olfactory receptor 10J5 in heart aorta, coronary artery, and endothelial cells and its functional role in angiogenesis. (PMID: 25791473) Kim SH … Park JH (Biochemical and biophysical research communications 2015) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3
  5. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. (PMID: 22939635) Reiner AP … Tang H (American journal of human genetics 2012) 3

Products for OR10J5 Gene

Sources for OR10J5 Gene