Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10J4 Gene

Aliases for OR10J4 Gene

  • Olfactory Receptor Family 10 Subfamily J Member 4 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 10, Subfamily J, Member 4 Pseudogene 2 3
  • Olfactory Receptor 10J4 3 4
  • OR10J4P 3 4
  • OST717 2 3
  • Olfactory Receptor, Family 10, Subfamily J, Member 4 (Gene/Pseudogene) 2
  • OR10J4 5

External Ids for OR10J4 Gene

Previous HGNC Symbols for OR10J4 Gene

  • OR10J4P

Previous GeneCards Identifiers for OR10J4 Gene

  • GC01P157670
  • GC01P157671
  • GC01P159401

Summaries for OR10J4 Gene

Entrez Gene Summary for OR10J4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR10J4 Gene

OR10J4 (Olfactory Receptor Family 10 Subfamily J Member 4 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10J3.

UniProtKB/Swiss-Prot Summary for OR10J4 Gene

Additional gene information for OR10J4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10J4 Gene

Genomics for OR10J4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10J4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159430 Enhancer 0.2 Ensembl 250.7 -1.1 -1103 0.6 OR10J4 OR10J3 FCER1A OR10J2P OR10J9P OR10J1 ENSG00000228560 HSALNG0007767
GH01J159427 Enhancer 0.4 ENCODE 0.7 -3.5 -3453 2.8 JUND MAFK EZH2 MNT OR10J3 OR10J2P FCER1A ENSG00000228560 OR10J4 OR10J9P OR10J1 HSALNG0007767
GH01J159439 Enhancer 0.3 Ensembl 0.4 +9.0 8996 2.4 RAD21 FCER1A OR10J2P ENSG00000228560 OR10J4 piR-56451-009 HSALNG0007767 OR10J1 OR10J5
GH01J159434 Enhancer 0.2 Ensembl 0.7 +4.4 4397 1.2 FCER1A OR10J2P ENSG00000228560 OR10J4 piR-56451-009 HSALNG0007767 OR10J1 OR10J5
GH01J159509 Enhancer 0.6 ENCODE 0.2 +77.6 77579 1.5 ATF3 YY1 CEBPB RXRA HNF4A ATF4 REST SP1 TRIM24 HNF4G HSALNG0007771 OR10J5 piR-58297-029 HSALNG0007770 OR10J4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10J4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10J4

Genomic Locations for OR10J4 Gene

Latest Assembly
chr1:159,432,204-159,433,138
(GRCh38/hg38)
Size:
935 bases
Orientation:
Plus strand

Previous Assembly
chr1:159,401,982-159,403,105
(GRCh37/hg19 by Entrez Gene)
Size:
1,124 bases
Orientation:
Plus strand

chr1:159,401,994-159,402,928
(GRCh37/hg19 by Ensembl)
Size:
935 bases
Orientation:
Plus strand

Genomic View for OR10J4 Gene

Genes around OR10J4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10J4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10J4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10J4 Gene

Proteins for OR10J4 Gene

  • Protein details for OR10J4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C629-O10J4_HUMAN
    Recommended name:
    Olfactory receptor 10J4
    Protein Accession:
    P0C629

    Protein attributes for OR10J4 Gene

    Size:
    311 amino acids
    Molecular mass:
    34891 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10J4 Gene

Post-translational modifications for OR10J4 Gene

No Post-translational modifications

Other Protein References for OR10J4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR10J4 Gene

Domains & Families for OR10J4 Gene

Gene Families for OR10J4 Gene

Protein Domains for OR10J4 Gene

Suggested Antigen Peptide Sequences for OR10J4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 10J4 (O10J4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C629

UniProtKB/Swiss-Prot:

O10J4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10J4: view

Function for OR10J4 Gene

Molecular function for OR10J4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10J4 Gene

Gene Ontology (GO) - Molecular Function for OR10J4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR10J4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10J4 Gene

Localization for OR10J4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10J4 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR10J4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with OR10J4: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR10J4 Gene

Pathways & Interactions for OR10J4 Gene

genes like me logo Genes that share pathways with OR10J4: view

Pathways by source for OR10J4 Gene

Interacting Proteins for OR10J4 Gene

Gene Ontology (GO) - Biological Process for OR10J4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA 21873635
genes like me logo Genes that share ontologies with OR10J4: view

No data available for SIGNOR curated interactions for OR10J4 Gene

Drugs & Compounds for OR10J4 Gene

No Compound Related Data Available

Transcripts for OR10J4 Gene

mRNA/cDNA for OR10J4 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10J4 Gene

No ASD Table

Relevant External Links for OR10J4 Gene

GeneLoc Exon Structure for
OR10J4

Expression for OR10J4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10J4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10J4 Gene



genes like me logo Genes that share expression patterns with OR10J4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10J4 Gene

Orthologs for OR10J4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10J4 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 30
  • 52 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Olfr218 30
  • 49 (a)
ManyToMany
Olfr1404 30
  • 47 (a)
ManyToMany
Or10j28-ps 45 Olfr1407-ps1
  • chr1:173,149,820-173,150,372
Dog
(Canis familiaris)
Mammalia -- 30
  • 49 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 47 (a)
OneToMany
Species where no ortholog for OR10J4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10J4 Gene

ENSEMBL:
Gene Tree for OR10J4 (if available)
TreeFam:
Gene Tree for OR10J4 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR10J4

Paralogs for OR10J4 Gene

(456) SIMAP similar genes for OR10J4 Gene using alignment to 1 proteins:

  • O10J4_HUMAN
genes like me logo Genes that share paralogs with OR10J4: view

Variants for OR10J4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR10J4 Gene

O10J4_HUMAN-P0C629
A single nucleotide deletion at position Ile-198 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10J4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for OR10J4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10J4
Leiden Open Variation Database (LOVD)
OR10J4

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR10J4 Gene

Disorders for OR10J4 Gene

Additional Disease Information for OR10J4

No disorders were found for OR10J4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10J4 Gene

Publications for OR10J4 Gene

  1. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I … Lancet D (PLoS biology 2007) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin EJ … Vasan RS (BMC medical genetics 2007) 40

Products for OR10J4 Gene

Sources for OR10J4 Gene