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Aliases for OR10H5 Gene

Aliases for OR10H5 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 5 2 3 5
  • Olfactory Receptor OR19-25 3 4
  • Olfactory Receptor OR19-26 3 4
  • Olfactory Receptor 10H5 3 4
  • Olfactory Receptor, Family 10, Subfamily H, Member 5 2
  • OR19-25 3
  • OR19-26 3

External Ids for OR10H5 Gene

Previous GeneCards Identifiers for OR10H5 Gene

  • GC19U990263
  • GC19P015766
  • GC19P015904

Summaries for OR10H5 Gene

Entrez Gene Summary for OR10H5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H5 Gene

OR10H5 (Olfactory Receptor Family 10 Subfamily H Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H1.

UniProtKB/Swiss-Prot for OR10H5 Gene

Additional gene information for OR10H5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10H5 Gene

Genomics for OR10H5 Gene

GeneHancer (GH) Regulatory Elements for OR10H5 Gene

Promoters and enhancers for OR10H5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015787 Enhancer 0.5 Ensembl 600.7 +1.4 1422 3 CREB1 RFX1 PKNOX1 FOS EGR2 OR10H5 CYP4F24P CYP4F12 OR10H1
GH19J016063 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +285.3 285252 18.7 ZNF473 SP1 CC2D1A ELF3 ZFX CTCF ZKSCAN8 CBFA2T2 ZNF148 NKRF TPM4 AKAP8 CHERP ENSG00000269578 BRD4 C19orf44 ENSG00000267904 ENSG00000268087 MED26 ENSG00000268743
GH19J015639 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 11.4 -146.7 -146658 3 CBFA2T2 CEBPG NFIB MAFK SP1 ZNF644 RXRA IKZF1 NFE2L2 CEBPA CYP4F3 CYP4F12 HSH2D CYP4F10P OR10H5 RAB8A LINC01835 BRD4 AKAP8 GC19M015646
GH19J015826 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +45.1 45104 12.9 SP1 ZFX ELF3 CC2D1A ZKSCAN8 CBFA2T2 ZNF148 MLLT1 POLR2A GTF2F1 ENSG00000273782 ENSG00000269578 AKAP8 MED26 SIN3B CHERP C19orf44 BRD4 CYP4F24P UCA1
GH19J015222 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -564.0 -564012 2.9 SP1 ZNF121 CSDE1 ZNF384 SP7 ELF1 KLF14 PRDM1 EGR1 CREB1 ENSG00000269635 NOTCH3 RNU6-782P BRD4 OR10H5 ENSG00000273218 WIZ SYDE1 SLC1A6 EPHX3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10H5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10H5 gene promoter:
  • AhR
  • AP-1
  • c-Fos
  • c-Jun
  • c-Myc
  • En-1
  • Max1
  • NF-1
  • NF-1/L
  • RP58

Genomic Locations for OR10H5 Gene

Genomic Locations for OR10H5 Gene
chr19:15,787,661-15,801,025
(GRCh38/hg38)
Size:
13,365 bases
Orientation:
Plus strand
chr19:15,904,761-15,905,892
(GRCh37/hg19)
Size:
1,132 bases
Orientation:
Plus strand

Genomic View for OR10H5 Gene

Genes around OR10H5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H5 Gene

Proteins for OR10H5 Gene

  • Protein details for OR10H5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGA6-O10H5_HUMAN
    Recommended name:
    Olfactory receptor 10H5
    Protein Accession:
    Q8NGA6
    Secondary Accessions:
    • Q6IFJ0
    • Q96R60

    Protein attributes for OR10H5 Gene

    Size:
    315 amino acids
    Molecular mass:
    34900 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H5 Gene

Post-translational modifications for OR10H5 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10H5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H5 Gene

Domains & Families for OR10H5 Gene

Gene Families for OR10H5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10H5 Gene

Suggested Antigen Peptide Sequences for OR10H5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-26 (O10H5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGA6

UniProtKB/Swiss-Prot:

O10H5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H5: view

Function for OR10H5 Gene

Molecular function for OR10H5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10H5 Gene

Gene Ontology (GO) - Molecular Function for OR10H5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10H5: view

Phenotypes for OR10H5 Gene

genes like me logo Genes that share phenotypes with OR10H5: view

Animal Model Products

CRISPR Products

miRNA for OR10H5 Gene

miRTarBase miRNAs that target OR10H5

Clone Products

  • Applied Biological Materials (abm): Clones for OR10H5 - Now 50% OFF >
  • * OR10H5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR10H5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR10H5 Gene

Localization for OR10H5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10H5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with OR10H5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10H5 Gene

Pathways & Interactions for OR10H5 Gene

genes like me logo Genes that share pathways with OR10H5: view

Pathways by source for OR10H5 Gene

Interacting Proteins for OR10H5 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000310704%0d9606.ENSP00000233596%0d9606.ENSP00000248572%0d9606.ENSP00000259030%0d9606.ENSP00000296142%0d9606.ENSP00000303482%0d
Selected Interacting proteins: ENSP00000310704 Q8NGA6-O10H5_HUMAN for OR10H5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR10H5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H5: view

No data available for SIGNOR curated interactions for OR10H5 Gene

Drugs & Compounds for OR10H5 Gene

No Compound Related Data Available

Transcripts for OR10H5 Gene

mRNA/cDNA for OR10H5 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OR10H5 Gene

Olfactory receptor, family 10, subfamily H, member 5:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR10H5 - Now 50% OFF >
  • * OR10H5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR10H5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H5 Gene

No ASD Table

Relevant External Links for OR10H5 Gene

GeneLoc Exon Structure for
OR10H5
ECgene alternative splicing isoforms for
OR10H5

Expression for OR10H5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10H5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10H5 Gene:

OR10H5

SOURCE GeneReport for Unigene cluster for OR10H5 Gene:

Hs.553676
genes like me logo Genes that share expression patterns with OR10H5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10H5 Gene

Orthologs for OR10H5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR10H1 35
  • 86 (a)
ManyToMany
-- 35
  • 84 (a)
ManyToMany
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 85 (a)
ManyToMany
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm4461 35 34
  • 84.08 (n)
ManyToMany
Olfr239 35
  • 84 (a)
ManyToMany
Olfr55 35
  • 84 (a)
ManyToMany
Olfr1564 17
rat
(Rattus norvegicus)
Mammalia Olr1092 34
  • 83.33 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 38 (a)
ManyToMany
Species where no ortholog for OR10H5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H5 Gene

ENSEMBL:
Gene Tree for OR10H5 (if available)
TreeFam:
Gene Tree for OR10H5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10H5: view image

Paralogs for OR10H5 Gene

(452) SIMAP similar genes for OR10H5 Gene using alignment to 1 proteins:

  • O10H5_HUMAN
genes like me logo Genes that share paralogs with OR10H5: view

Variants for OR10H5 Gene

Sequence variations from dbSNP and Humsavar for OR10H5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000625131 -- 15,794,126(+) G/C coding_sequence_variant, missense_variant
rs1001352764 -- 15,793,878(+) CAAAAAC/C upstream_transcript_variant
rs1003023898 -- 15,793,003(+) T/G upstream_transcript_variant
rs1004206669 -- 15,792,426(+) A/T upstream_transcript_variant
rs1004413938 -- 15,792,155(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10H5 Gene

Variant ID Type Subtype PubMed ID
esv2671181 CNV deletion 23128226
esv2718244 CNV deletion 23290073
esv3334671 CNV duplication 20981092
nsv1060711 CNV gain 25217958
nsv1064684 CNV gain 25217958
nsv1133007 OTHER inversion 24896259
nsv2425 CNV insertion 18451855
nsv833766 CNV loss 17160897

Variation tolerance for OR10H5 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.04; 96.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10H5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10H5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H5 Gene

Disorders for OR10H5 Gene

Additional Disease Information for OR10H5

No disorders were found for OR10H5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10H5 Gene

Publications for OR10H5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR10H5 Gene

Sources for OR10H5 Gene

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