Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10H4 Gene

Aliases for OR10H4 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 4 2 3 5
  • Olfactory Receptor OR19-28 3 4
  • Olfactory Receptor 10H4 3 4
  • Olfactory Receptor, Family 10, Subfamily H, Member 4 2
  • OR19-28 3
  • OR10H4 5

External Ids for OR10H4 Gene

Previous GeneCards Identifiers for OR10H4 Gene

  • GC19U990264
  • GC19P015921
  • GC19P015922
  • GC19P016059

Summaries for OR10H4 Gene

Entrez Gene Summary for OR10H4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H4 Gene

OR10H4 (Olfactory Receptor Family 10 Subfamily H Member 4) is a Protein Coding gene. Diseases associated with OR10H4 include Atrial Septal Defect 3 and Pachyonychia Congenita 1. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H3.

UniProtKB/Swiss-Prot Summary for OR10H4 Gene

Gene Wiki entry for OR10H4 Gene

Additional gene information for OR10H4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10H4 Gene

Genomics for OR10H4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10H4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10H4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10H4

Top Transcription factor binding sites by QIAGEN in the OR10H4 gene promoter:
  • CREB
  • deltaCREB
  • E47
  • ITF-2
  • MRF-2
  • PPAR-gamma1
  • PPAR-gamma2
  • SREBP-1c
  • Tal-1
  • Tal-1beta

Genomic Locations for OR10H4 Gene

Genomic Locations for OR10H4 Gene
chr19:15,944,299-15,950,350
(GRCh38/hg38)
Size:
6,052 bases
Orientation:
Plus strand
chr19:16,059,818-16,060,768
(GRCh37/hg19)
Size:
951 bases
Orientation:
Plus strand

Genomic View for OR10H4 Gene

Genes around OR10H4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H4 Gene

Proteins for OR10H4 Gene

  • Protein details for OR10H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGA5-O10H4_HUMAN
    Recommended name:
    Olfactory receptor 10H4
    Protein Accession:
    Q8NGA5
    Secondary Accessions:
    • Q6IFJ2
    • Q96R57

    Protein attributes for OR10H4 Gene

    Size:
    316 amino acids
    Molecular mass:
    35765 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H4 Gene

Post-translational modifications for OR10H4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10H4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H4 Gene

Domains & Families for OR10H4 Gene

Gene Families for OR10H4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10H4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR10H4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-28 (O10H4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGA5

UniProtKB/Swiss-Prot:

O10H4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H4: view

Function for OR10H4 Gene

Molecular function for OR10H4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10H4 Gene

Gene Ontology (GO) - Molecular Function for OR10H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10H4: view

Phenotypes for OR10H4 Gene

genes like me logo Genes that share phenotypes with OR10H4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10H4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10H4 Gene

Localization for OR10H4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10H4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with OR10H4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10H4 Gene

Pathways & Interactions for OR10H4 Gene

genes like me logo Genes that share pathways with OR10H4: view

Pathways by source for OR10H4 Gene

Interacting Proteins for OR10H4 Gene

Gene Ontology (GO) - Biological Process for OR10H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H4: view

No data available for SIGNOR curated interactions for OR10H4 Gene

Drugs & Compounds for OR10H4 Gene

No Compound Related Data Available

Transcripts for OR10H4 Gene

mRNA/cDNA for OR10H4 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10H4

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H4 Gene

No ASD Table

Relevant External Links for OR10H4 Gene

GeneLoc Exon Structure for
OR10H4

Expression for OR10H4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10H4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10H4

SOURCE GeneReport for Unigene cluster for OR10H4 Gene:

Hs.553579
genes like me logo Genes that share expression patterns with OR10H4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10H4 Gene

Orthologs for OR10H4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC468757 30
  • 98.63 (n)
OR10H4 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC506323 30
  • 85.45 (n)
-- 31
  • 82 (a)
ManyToMany
-- 31
  • 81 (a)
ManyToMany
-- 31
  • 80 (a)
ManyToMany
-- 31
  • 80 (a)
ManyToMany
-- 31
  • 80 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr63 31
  • 76 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 67 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 62 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 45 (a)
ManyToMany
Species where no ortholog for OR10H4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10H4 Gene

ENSEMBL:
Gene Tree for OR10H4 (if available)
TreeFam:
Gene Tree for OR10H4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10H4: view image

Paralogs for OR10H4 Gene

(446) SIMAP similar genes for OR10H4 Gene using alignment to 1 proteins:

  • O10H4_HUMAN
genes like me logo Genes that share paralogs with OR10H4: view

Variants for OR10H4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10H4 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11880184 - p.Thr281Ala
rs16980822 - p.His144Arg
rs16980994 - p.Asn100Lys

Additional dbSNP identifiers (rs#s) for OR10H4 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR10H4 Gene

Variant ID Type Subtype PubMed ID
esv2718244 CNV deletion 23290073
nsv1064684 CNV gain 25217958
nsv833766 CNV loss 17160897
nsv960803 CNV duplication 23825009

Variation tolerance for OR10H4 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.08; 87.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10H4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10H4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H4 Gene

Disorders for OR10H4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR10H4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
atrial septal defect 3
  • asd3
pachyonychia congenita 1
  • pc1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with OR10H4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR10H4 Gene

Publications for OR10H4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10H4 Gene

Sources for OR10H4 Gene