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Aliases for OR10H4 Gene

Aliases for OR10H4 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 4 2 3 5
  • Olfactory Receptor OR19-28 3 4
  • Olfactory Receptor, Family 10, Subfamily H, Member 4 2
  • Olfactory Receptor 10H4 3
  • OR19-28 3

External Ids for OR10H4 Gene

Previous GeneCards Identifiers for OR10H4 Gene

  • GC19U990264
  • GC19P015921
  • GC19P015922
  • GC19P016059

Summaries for OR10H4 Gene

Entrez Gene Summary for OR10H4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H4 Gene

OR10H4 (Olfactory Receptor Family 10 Subfamily H Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H3.

UniProtKB/Swiss-Prot for OR10H4 Gene

  • Odorant receptor.

Gene Wiki entry for OR10H4 Gene

Additional gene information for OR10H4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10H4 Gene

Genomics for OR10H4 Gene

GeneHancer (GH) Regulatory Elements for OR10H4 Gene

Promoters and enhancers for OR10H4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015826 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -111.5 -111534 12.9 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ENSG00000273782 ENSG00000269578 AKAP8 MED26 SIN3B CHERP C19orf44 BRD4 CYP4F24P UCA1
GH19J016040 Enhancer 1 Ensembl ENCODE 10.5 +96.9 96932 1.5 ELF3 RB1 ARID4B IRF4 ZNF48 RAD21 YY1 ZNF335 ZNF121 ZNF143 GC19P020254 GC19P020255 GC19P020261 GC19P020303 GC19P020306 GC19P020318 GC19P020335 GC19P020348 GC19P020357 GC19P020361
GH19J016001 Enhancer 0.9 Ensembl ENCODE 10.9 +58.1 58053 1.9 IRF2 MAX CEBPG BATF IRF4 RAD21 ZNF7 RELA POLR2A RXRA LINC00661 CYP4F11 OR10H4 PIRC97 CYP4F9P PIR55720
GH19J015824 Enhancer 0.7 dbSUPER 10.8 -119.3 -119343 1.7 BACH1 ZNF644 ZNF507 IRF9 ZNF766 NFE2 ZNF639 ZNF197 ZNF740 E2F5 GC19P015826 ZNF861P CYP4F24P AKAP8 CHERP ENSG00000267904 C19orf44 ENSG00000269578 OR10H5 ENSG00000268087
GH19J016168 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +224.7 224662 1.6 BCOR ZNF768 USF1 MAX ZMYM3 ZNF280A POLR2A ADNP NFYB SMARCC2 OR10H3 OR10H2 AP1M1 OR10H4 CIB3 GC19M016168 ENSG00000269243
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10H4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10H4 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • Tal-1
  • E47
  • deltaCREB
  • CREB
  • MRF-2
  • Tal-1beta
  • ITF-2
  • SREBP-1c

Genomic Locations for OR10H4 Gene

Genomic Locations for OR10H4 Gene
chr19:15,944,299-15,950,350
(GRCh38/hg38)
Size:
6,052 bases
Orientation:
Plus strand
chr19:16,059,818-16,060,768
(GRCh37/hg19)
Size:
951 bases
Orientation:
Plus strand

Genomic View for OR10H4 Gene

Genes around OR10H4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H4 Gene

Proteins for OR10H4 Gene

  • Protein details for OR10H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGA5-O10H4_HUMAN
    Recommended name:
    Olfactory receptor 10H4
    Protein Accession:
    Q8NGA5
    Secondary Accessions:
    • Q6IFJ2
    • Q96R57

    Protein attributes for OR10H4 Gene

    Size:
    316 amino acids
    Molecular mass:
    35765 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H4 Gene

Post-translational modifications for OR10H4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10H4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H4 Gene

Domains & Families for OR10H4 Gene

Gene Families for OR10H4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10H4 Gene

Suggested Antigen Peptide Sequences for OR10H4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGA5

UniProtKB/Swiss-Prot:

O10H4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H4: view

Function for OR10H4 Gene

Molecular function for OR10H4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10H4 Gene

Gene Ontology (GO) - Molecular Function for OR10H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,IBA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA --
genes like me logo Genes that share ontologies with OR10H4: view
genes like me logo Genes that share phenotypes with OR10H4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10H4 Gene

Localization for OR10H4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10H4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with OR10H4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10H4 Gene

Pathways & Interactions for OR10H4 Gene

genes like me logo Genes that share pathways with OR10H4: view

Pathways by source for OR10H4 Gene

Interacting Proteins for OR10H4 Gene

Gene Ontology (GO) - Biological Process for OR10H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
GO:0007268 chemical synaptic transmission IBA --
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H4: view

No data available for SIGNOR curated interactions for OR10H4 Gene

Drugs & Compounds for OR10H4 Gene

No Compound Related Data Available

Transcripts for OR10H4 Gene

mRNA/cDNA for OR10H4 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10H4 Gene

Olfactory receptor, family 10, subfamily H, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H4 Gene

No ASD Table

Relevant External Links for OR10H4 Gene

GeneLoc Exon Structure for
OR10H4
ECgene alternative splicing isoforms for
OR10H4

Expression for OR10H4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10H4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10H4 Gene:

OR10H4

SOURCE GeneReport for Unigene cluster for OR10H4 Gene:

Hs.553579
genes like me logo Genes that share expression patterns with OR10H4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10H4 Gene

Orthologs for OR10H4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468757 33
  • 98.63 (n)
OR10H4 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC506323 33
  • 85.45 (n)
-- 34
  • 82 (a)
ManyToMany
-- 34
  • 81 (a)
ManyToMany
-- 34
  • 80 (a)
ManyToMany
-- 34
  • 80 (a)
ManyToMany
-- 34
  • 80 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr63 34
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
-- 34
  • 62 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 45 (a)
ManyToMany
Species where no ortholog for OR10H4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H4 Gene

ENSEMBL:
Gene Tree for OR10H4 (if available)
TreeFam:
Gene Tree for OR10H4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10H4: view image

Paralogs for OR10H4 Gene

(446) SIMAP similar genes for OR10H4 Gene using alignment to 1 proteins:

  • O10H4_HUMAN
genes like me logo Genes that share paralogs with OR10H4: view

Variants for OR10H4 Gene

Sequence variations from dbSNP and Humsavar for OR10H4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000277481 -- 15,949,097(+) G/T coding_sequence_variant, synonymous_variant
rs1000496488 -- 15,949,991(+) G/C downstream_transcript_variant
rs1000538554 -- 15,947,069(+) T/G upstream_transcript_variant
rs1000565641 -- 15,948,882(+) A/G upstream_transcript_variant
rs1001015465 -- 15,950,206(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10H4 Gene

Variant ID Type Subtype PubMed ID
esv2718244 CNV deletion 23290073
nsv1064684 CNV gain 25217958
nsv833766 CNV loss 17160897
nsv960803 CNV duplication 23825009

Variation tolerance for OR10H4 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.08; 87.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10H4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10H4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H4 Gene

Disorders for OR10H4 Gene

Additional Disease Information for OR10H4

No disorders were found for OR10H4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10H4 Gene

Publications for OR10H4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10H4 Gene

Sources for OR10H4 Gene

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